Threshold J/ψ−J/\psi- production in nucleon-nucleon collisions

We analyze $J/\psi-$ production in nucleon-nucleon collisions near threshold in the framework of a general model independent formalism, which can be applied to any reaction $N+N\to N+N+V^0$, where $V^0=\omega$, $\phi$, or $J/\psi$. Such reactions show large isotopic effects: a large difference for $pp$- and $pn$-collisions, which is due to the different spin structure of the corresponding matrix elements. The analysis of the spin structure and of the polarization observables is based on symmetry properties of the strong interaction. Using existing experimental data on the different decays of $J/\psi-$meson, we suggest a model for $N+N\to N+N+J/\psi$, based on $t-$channel $\eta+\pi$-exchanges. We predict polarization phenomena for the $n+p\to n+p+J/\psi$-reaction and the ratio of cross sections for $np$ and $pp$-collisions. For the processes $\eta(\pi)+N\to N+J/\psi$ we apply two different approaches: vector meson exchange and local four-particle interaction. In both cases we find larger $J/\psi$-production in $np$-collisions, with respect to $pp$-collisions.Comment: 17 pages, 6 figure

Considerations on rescattering effects for threshold photo- and electro-production of π0\pi^0 on deuteron

We show that for the S-state $\pi^0$-production in processes $\gamma+d\to d+\pi^0$ and $e^-+d\to e^-+d+\pi^0$ the rescattering effects due to the transition: $\gamma+d\to p+p+\pi^-$ (or $n+n+\pi^+)\to d+\pi^0$ are cancelled out due to the Pauli principle. The large values for these effects predicted in the past may result from the fact that the spin structure of the corresponding matrix element and the necessary antisymmetrization induced by the presence of identical protons (or neutrons) in the intermediate state was not taken into account accurately. One of the important consequences of these considerations is that $\pi^0$ photo- and electro-production on deuteron near threshold can bring direct information about elementary neutron amplitudes.Comment: Add a new sectio

The X-ray Telescope of CAST

The Cern Axion Solar Telescope (CAST) is in operation and taking data since 2003. The main objective of the CAST experiment is to search for a hypothetical pseudoscalar boson, the axion, which might be produced in the core of the sun. The basic physics process CAST is based on is the time inverted Primakoff effect, by which an axion can be converted into a detectable photon in an external electromagnetic field. The resulting X-ray photons are expected to be thermally distributed between 1 and 7 keV. The most sensitive detector system of CAST is a pn-CCD detector combined with a Wolter I type X-ray mirror system. With the X-ray telescope of CAST a background reduction of more than 2 orders off magnitude is achieved, such that for the first time the axion photon coupling constant g_agg can be probed beyond the best astrophysical constraints g_agg < 1 x 10^-10 GeV^-1.Comment: 19 pages, 25 figures and images, replaced by the revised version accepted for publication in New Journal of Physic

Neutral weak currents in pion electroproduction on the nucleon

Parity violating asymmetry in inclusive scattering of longitudinally polarized electrons by unpolarized protons with $\pi^0$ or $\pi^+$ meson production, is calculated as a function of the momentum transfer squared $Q^2$ and the total energy $W$ of the $\pi N$-system. This asymmetry, which is induced by the interference of the one-photon exchange amplitude with the parity-odd part of the $Z^0$-exchange amplitude, is calculated for the $\gamma^*(Z^*)+p\to N+\pi$ processes ($\gamma^*$ is a virtual photon and $Z^*$ a virtual Z-boson) considering the $\Delta$-contribution in the $s-$channel, the standard Born contributions and vector meson ($\rho$ and $\omega$) exchanges in the $t-$channel. Taking into account the known isotopic properties of the hadron electromagnetic and neutral currents, we show that the P-odd term is the sum of two contributions. The main term is model independent and it can be calculated exactly in terms of fundamental constants. It is found to be linear in $Q^2$. The second term is a relatively small correction which is determined by the isoscalar component of the electromagnetic current. Near threshold and in the $\Delta$-region, this isoscalar part is much smaller (in absolute value) than the isovector one: its contribution to the asymmetry depend on the polarization state (longitudinal or transverse) of the virtual photon.Comment: 30 pages 9 figure

Money talks: moral economies of earning a living in neoliberal East Africa

Neoliberal restructuring has targeted not just the economy, but also polity, society and culture, in the name of creating capitalist market societies. The societal repercussions of neoliberal policy and reform in terms of moral economy remain understudied. This article seeks to address this gap by analysing moral economy characteristics and dynamics in neoliberalised communities, as perceived by traders in Uganda and sex workers in Kenya. The interview data reveal perceived drivers that contributed to a significant moral dominance of money, self-interest, short-termism, opportunism and pragmatism. Equally notable are a perceived (i) close interaction between political–economic and moral–economic dynamics, and (ii) significant impact of the political–economic structure on moral agency. Respondents primarily referred to material factors usually closely linked to neoliberal reform, as key drivers of local moral economies. We thus speak of a neoliberalisation of moral economies, itself part of the wider process of embedding and locking-in market society structures in the two countries. An improved political economy of moral economy can help keep track of this phenomenon

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.

While the association of Epstein-Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, the precise role of the virus in BL pathogenesis is not fully resolved. EBV can be lost spontaneously from some BL cell lines, and these EBV-loss lymphoma cells reportedly have a survival disadvantage. Here we have generated an extensive panel of EBV-loss clones from multiple BL backgrounds and examined their phenotype comparing them to their isogenic EBV-positive counterparts. We report that, while loss of EBV from BL cells is rare, it is consistently associated with an enhanced predisposition to undergo apoptosis and reduced tumorigenicity in vivo. Importantly, reinfection of EBV-loss clones with EBV, but surprisingly not transduction with individual BL-associated latent viral genes, restored protection from apoptosis. Expression profiling and functional analysis of apoptosis-related proteins and transcripts in BL cells revealed that EBV inhibits the upregulation of the proapoptotic BH3-only proteins, BIM and PUMA. We conclude that latent EBV genes cooperatively enhance the survival of BL cells by suppression of the intrinsic apoptosis pathway signalling via inhibition of the potent apoptosis initiators, BIM and PUMA.Cell Death and Differentiation advance online publication, 29 September 2017; doi:10.1038/cdd.2017.150

A narrativa do entretenimento na CazéTV durante a cobertura dos Jogos Olímpicos de Paris 2024

Este artigo busca compreender a apropriação das lógicas do entretenimento nas transmissões esportivas em streaming, com foco principal na CazéTV, durante os Jogos Olímpicos de Paris 2024. Sob a ótica da narrativa do entretenimento, são destacados episódios polêmicos exibidos pelo canal no YouTube e as consequências da produção de um conteúdo esportivo ancorado na dramatização e espetacularização. Reflexões sobre as problemáticas que envolvem a aplicação de estratégias do entretenimento para o engajamento do público são norteadas pelos princípios éticos do jornalismo, no sentido de discutir a importância dessa instância balizadora na produção e transmissão de conteúdos de eventos esportivos por canais digitais que ocupam um espaço antes dominado pelos meios de comunicação tradicionais

Doxorubicin-induced chronic dilated cardiomyopathy—the apoptosis hypothesis revisited

The chemotherapeutic agent doxorubicin (DOX) has significantly increased survival rates of pediatric and adult cancer patients. However, 10% of pediatric cancer survivors will 10–20 years later develop severe dilated cardiomyopathy (DCM), whereby the exact molecular mechanisms of disease progression after this long latency time remain puzzling. We here revisit the hypothesis that elevated apoptosis signaling or its increased likelihood after DOX exposure can lead to an impairment of cardiac function and cause a cardiac dilation. Based on recent literature evidence, we first argue why a dilated phenotype can occur when little apoptosis is detected. We then review findings suggesting that mature cardiomyocytes are protected against DOX-induced apoptosis downstream, but not upstream of mitochondrial outer membrane permeabilisation (MOMP). This lack of MOMP induction is proposed to alter the metabolic phenotype, induce hypertrophic remodeling, and lead to functional cardiac impairment even in the absence of cardiomyocyte apoptosis. We discuss findings that DOX exposure can lead to increased sensitivity to further cardiomyocyte apoptosis, which may cause a gradual loss in cardiomyocytes over time and a compensatory hypertrophic remodeling after treatment, potentially explaining the long lag time in disease onset. We finally note similarities between DOX-exposed cardiomyocytes and apoptosis-primed cancer cells and propose computational system biology as a tool to predict patient individual DOX doses. In conclusion, combining recent findings in rodent hearts and cardiomyocytes exposed to DOX with insights from apoptosis signal transduction allowed us to obtain a molecularly deeper insight in this delayed and still enigmatic pathology of DC

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently identified inhibitory receptor on T cells and natural killer (NK) cells. In this study, we examined TIGIT expression on T cell subsets from CLL patients. While we did not observe any differences in TIGIT expression in CD8C T cells of healthy controls and CLL cells, we found an enrichment of TIGITC T cells in the CD4C T cell compartment in CLL. Intriguingly, CLL patients with an advanced disease stage displayed elevated numbers of CD4C TIGITC T cells compared to low risk patients. Autologous CLL-T cell co-culture assays revealed that depleting CD4C TIGITC expressing T cells from co-cultures significantly decreased CLL viability. Accordingly, a supportive effect of TIGITCCD4C T cells on CLL cells in vitro could be recapitulated by blocking the interaction of TIGIT with its ligands using TIGIT-Fc molecules, which also impeded the T cell specific production of CLL-prosurvival cytokines. Our data reveal that TIGITCCD4CT cells provide a supportive microenvironment for CLL cells, representing a potential therapeutic target for CLL treatment