Tubulation pattern of membrane vesicles coated with bio filaments

Narrow membrane tubes are commonly pulled out from the surface of phospholipid vesicles using forces applied either through laser or magnetic tweezers or through the action of processive motor proteins. Recent examples have emerged where such tubes spontaneously grow from vesicles coated with bioactive cytoskeletal filaments (e.g. FtsZ, microtubule) in the presence GTP. We show how a soft vesicle deforms due to the interplay between its topology, local curvature and the forces due to the active filaments. We present results from Dynamically Triangulated Monte Carlo simulations of a spherical continuum membrane coated with a nematic field and show how the intrinsic curvature of the filaments and their ordering interactions drive membrane tubulation. We predict interesting patterns of nematic defects, on curved 2D membrane surfaces, which promote tube formation. Implication of our model for more dynamic cases where vesicles coated with an active mixture of microtubule and myosin show shape oscillation, are also discussed. All these cases point to a common theme that defect locations on 2D membrane surfaces are hot spots of membrane deformation activity.Comment: 8 pages, 7 figure

Nature of Radiation-Induced Defects in Quartz

Although quartz ($\rm \alpha$-form) is a mineral used in numerous applications wherein radiation exposure is an issue, the nature of the atomistic defects formed during radiation-induced damage have not been fully clarified. Especially, the extent of oxygen vacancy formation is still debated, which is an issue of primary importance as optical techniques based on charged oxygen vacancies have been utilized to assess the level of radiation damage in quartz. In this paper, molecular dynamics (MD) simulations are applied to study the effects of ballistic impacts on the atomic network of quartz. We show that the defects that are formed mainly consist of over-coordinated Si and O, as well as Si--O connectivity defects, e.g., small Si--O rings and edge-sharing Si tetrahedra. Oxygen vacancies, on the contrary, are found in relatively low abundance, suggesting that characterizations based on $E^{\prime}$ centers do not adequately capture radiation-induced structural damage in quartz. Finally, we evaluate the dependence on the incident energy, of the amount of each type of the point defects formed, and quantify unambiguously the threshold displacement energies for both O and Si atoms. These results provide a comprehensive basis to assess the nature and extent of radiation damage in quartz

An Approach to Autonomizing Legacy Systems

Adding adaptation capabilities to existing distributed systems is a major concern. The question addressed here is how to retrofit existing systems with self-healing, adaptation and/or self management capabilities. The problem is obviously intensified for 'systems of systems' composed of components, whether new or legacy, that may have been developed by different vendors, mixing and matching COTS and 'open source' components. This system composition model is expected to be increasingly common in high performance computing. The usual approach is to train technicians to understand the complexities of these components and their connections, including performance tuning parameters, so that they can then manually monitor and reconfigure the system as needed. We envision instead attaching a 'standard' feedback loop infrastructure to existing distributed systems for the purposes of continual monitoring and dynamically adapting their activities and performance. (This approach can also be applied to 'new' systems, as an alternative to 'building in' adaptation facilities, but we do not address that here.) Our proposed infrastructure consists of multiple layers with the objectives of probing, measuring and reporting of activity and state within the execution of the legacy system among its components and connectors; gauging, analysis and interpretation of the reported events; and possible feedback to focus the probes and gauges to drill deeper, or when necessary - direct but automatic reconfiguration of the running system

An Active Events Model for Systems Monitoring

We present an interaction model enabling data-source probes and action-based gauges to communicate using an intelligent event model known as ActEvents. ActEvents build on conventional event concepts by associating structural and semantic information with raw data, thereby allowing recipients to be able to dynamically understand the content of new kinds of events. Two submodels of ActEvents are proposed: SmartEvents, which are XML-structured events containing references to their syntactic and semantic models, and Gaugents, which are heavier but more flexible intelligent mobile software agents. This model is presented in light of DARPA's DASADA program, where ActEvents are used in a larger-scale subsystem, called KX, which supports continual validation of distributed, component-based systems. ActEvents are emitted by probes in this architecture, and propagated to gauges, where 'measurements' of the raw data associated with probes are made, thereby continually determining updated target-system properties. ActEvents are also proposed as solutions for a number of other applications, including a distributed collaborative virtual environment (CVE) known as CHIME

Quaternion Gravi-Electromagnetism

Defining the generalized charge, potential, current and generalized fields as complex quantities where real and imaginary parts represent gravitation and electromagnetism respectively, corresponding field equation, equation of motion and other quantum equations are derived in manifestly covariant manner. It has been shown that the field equations are invariant under Lorentz as well as duality transformations. It has been shown that the quaternionic formulation presented here remains invariant under quaternion transformations.Comment: Key Words: Quaternion, dyons, gravito-dyons, gravi-electromagnetism. PACS No.: 04.90. +e ; 14.80. H

Radiative falloff in the background of rotating black hole

We study numerically the late-time tails of linearized fields with any spin $s$ in the background of a spinning black hole. Our code is based on the ingoing Kerr coordinates, which allow us to penetrate through the event horizon. The late time tails are dominated by the mode with the least multipole moment $\ell$ which is consistent with the equatorial symmetry of the initial data and is equal to or greater than the least radiative mode with $s$ and the azimuthal number $m$.Comment: 5 pages, 4 Encapsulated PostScript figures; Accepted to Phys. Rev. D (Rapid Communication

Intermediate behavior of Kerr tails

The numerical investigation of wave propagation in the asymptotic domain of Kerr spacetime has only recently been possible thanks to the construction of suitable hyperboloidal coordinates. The asymptotics revealed an apparent puzzle in the decay rates of scalar fields: the late-time rates seemed to depend on whether finite distance observers are in the strong field domain or far away from the rotating black hole, an apparent phenomenon dubbed "splitting". We discuss far-field "splitting" in the full field and near-horizon "splitting" in certain projected modes using horizon-penetrating, hyperboloidal coordinates. For either case we propose an explanation to the cause of the "splitting" behavior, and we determine uniquely decay rates that previous studies found to be ambiguous or immeasurable. The far-field "splitting" is explained by competition between projected modes. The near-horizon "splitting" is due to excitation of lower multipole modes that back excite the multipole mode for which "splitting" is observed. In both cases "splitting" is an intermediate effect, such that asymptotically in time strong field rates are valid at all finite distances. At any finite time, however, there are three domains with different decay rates whose boundaries move outwards during evolution. We then propose a formula for the decay rate of tails that takes into account the inter--mode excitation effect that we study.Comment: 16 page