System for monitorering av forskerrekruttering : Dokumentasjon av, og resultater fra, et pilotprosjekt

Dette arbeidsnotatet dokumenterer arbeidet med pilotstudien av forskerrekrutteringsmonitoren, som er et samarbeid mellom NIFU og SSB, og med NSD som dataleverandør. Fokuset er på metode og prosess, men vi presenterer også noen resultater. Arbeidet med å etablere en forskerrekrutteringsmonitor er en del av FoU-statistikkavtalen som NIFU og SSB har med Forskningsrådet. Vi har i pilotstudien tatt for oss personer som har inngått doktorgradsavtaler i årene 2008, 2011 og 2012. Hovedformålet med pilotstudien har vært å teste grunnlagsdata, med mål om å sikre best mulig datakvalitet, samt utarbeide rutiner for en fullskala rekrutteringsmonitor

Mer mangfoldstatistikk. Statistikk om innvandrere og etterkommere av innvandrere i norsk forskning og høyere utdanning. Revidert utgave.

Dette arbeidsnotatet inneholder statistikk om mangfold, i betydningen innvandringsstatus, blant de tilsatte i norsk forskning og høyere utdanning. Statistikken er fremstilt av Statistisk sentralbyrå (SSB) og NIFU i fellesskap, på oppdrag fra Kunnskapsdepartementet. Dette arbeidsnotatet er en revidert versjon av NIFU arbeidsnotat 2016:17, etter endringer i tallmaterialet. Det er redegjort nærmere for endringene innledningsvis i dette arbeidsnotatet

Mangfoldstatistikk: Statistikk om innvandrere og etterkommere av innvandrere i norsk forskning og høyere utdanning

Dette arbeidsnotatet inneholder statistikk om mangfold, i betydningen innvandringsstatus, blant de tilsatte i norsk forskning og høyere utdanning. Statistikken er fremstilt av Statistisk sentralbyrå (SSB) og NIFU i fellesskap, på oppdrag fra Kunnskapsdepartementet

Randomized Comparison of Final Kissing Balloon Dilatation Versus No Final Kissing Balloon Dilatation in Patients With Coronary Bifurcation Lesions Treated With Main Vessel Stenting: The Nordic-Baltic Bifurcation Study III

Background— It is unknown whether the preferred 1-stent bifurcation stenting approach with stenting of the main vessel (MV) and optional side branch stenting using drug-eluting stents should be finalized by a kissing balloon dilatation (FKBD). Therefore, we compared strategies of MV stenting with and without FKBD. Methods and Results— We randomized 477 patients with a bifurcation lesion to FKBD (n=238) or no FKBD (n=239) after MV stenting. The primary end point was major adverse cardiac events: cardiac death, non–procedure-related index lesion myocardial infarction, target lesion revascularization, or stent thrombosis within 6 months. The 6-month major adverse cardiac event rates were 2.1% and 2.5% ( P =1.00) in the FKBD and no-FKBD groups, respectively. Procedure and fluoroscopy times were longer and more contrast media was needed in the FKBD group than in the no-FKBD group. Three hundred twenty-six patients had a quantitative coronary assessment. At 8 months, the rate of binary (re)stenosis in the entire bifurcation lesion (MV and side branch) was 11.0% versus 17.3% ( P =0.11), in the MV was 3.1% versus 2.5% ( P =0.68), and in the side branch was 7.9% versus 15.4% ( P =0.039) in the FKBD versus no-FKBD groups, respectively. In patients with true bifurcation lesions, the side branch restenosis rate was 7.6% versus 20.0% ( P =0.024) in the FKBD and no-FKBD groups, respectively. Conclusions— MV stenting strategies with and without FKBD were associated with similar clinical outcomes. FKBD reduced angiographic side branch (re)stenosis, especially in patients with true bifurcation lesions. The simple no-FKBD procedures resulted in reduced use of contrast media and shorter procedure and fluoroscopy times. Long-term data on stent thrombosis are needed. Clinical Trial Registration— URL: http://clinicaltrials.gov . Unique identifier: NCT00914199. </jats:sec

Multi-state models and arthroplasty histories after unilateral total hip arthroplasties: Introducing the Summary Notation for Arthroplasty Histories

Background and purpose: An increasing number of patients have several joint replacement procedures during their lifetime. We investigated the use and suitability of multi-state model techniques in providing a more comprehensive analysis and description of complex arthroplasty histories held in arthroplasty registries than are allowed for with traditional survival methods. Patients and methods: We obtained data from the Australian Orthopaedic Association National Joint Replacement Registry on patients (n = 84,759) who had undergone a total hip arthroplasty for osteoarthritis in the period 2002–2008. We set up a multi-state model where patients were followed from their first recorded arthroplasty to several possible states: revision of first arthroplasty, either a hip or knee as second arthroplasty, revision of the second arthroplasty, and death. The Summary Notation for Arthroplasty Histories (SNAH) was developed in order to help to manage and analyze this type of data. Results: At the end of the study period, 12% of the 84,759 patients had received a second hip, 3 times as many as had received a knee. The estimated probabilities of having received a second arthroplasty decreased with age. Males had a lower transition rate for receiving a second arthroplasty, but a higher mortality rate. Interpretation: Multi-state models in combination with SNAH codes are well suited to the management and analysis of arthroplasty registry data on patients who experience multiple joint procedures over time. We found differences in the progression of joint replacement procedures after the initial total hip arthroplasty regarding type of joint, age, and sex.Marianne H Gillam, Philip Ryan, Amy Salter, Stephen E Grave

ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data

Background: Research studies exploring the determinants of disease require sufficient statistical power to detect meaningful effects. Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. Methods that facilitate the sharing of research data that are sympathetic with these issues and which allow flexible and detailed statistical analyses are therefore in critical need. We have created a software platform for the Virtual Pooling and Analysis of Research data (ViPAR), which employs free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations. Methods: Database federation permits controlled access to remotely located datasets from a central location. The Secure Shell protocol allows data to be securely exchanged between devices over an insecure network. ViPAR combines these free technologies into a solution that facilitates ‘virtual pooling’ where data can be temporarily pooled into computer memory and made available for analysis without the need for permanent central storage. Results: Within the ViPAR infrastructure, remote sites manage their own harmonized research dataset in a database hosted at their site, while a central server hosts the data federation component and a secure analysis portal. When an analysis is initiated, requested data are retrieved from each remote site and virtually pooled at the central site. The data are then analysed by statistical software and, on completion, results of the analysis are returned to the user and the virtually pooled data are removed from memory. Conclusions: ViPAR is a secure, flexible and powerful analysis platform built on open source technology that is currently in use by large international consortia, and is made publicly available at http://bioinformatics.childhealthresearch.org.au/software/vipar/publishedVersio