Best Practices for Training the Structures Flight Test Engineer

The Structures Flight from 412th Test Wing and the Aerostructures Branch at NASA Armstrong Flight Research Center at Edwards Air Force Base have developed a set of best practices for training a structures flight test engineer. These practices represent the hard-won lessons learned and best practices from training generations of engineers to perform high risk envelope expansion and developmental flight test. Collectively, these organizations have tested many of the world's most advanced and innovative aircraft, including the B-2, C-17, F-22, F-35, RQ-4, X-29, F-18 High Angle of Attack Research Vehicle, X-53, G-III Adaptive Compliant Trailing Edge, and X-56

Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels

The second messenger for closure of M/KCNQ potassium channels in post-ganglionic neurons and central neurons had remained as a 'mystery in the neuroscience field' for over 25 years. However, recently the details of the pathway leading from muscarinic acetylcholine receptor (mAChR)-stimulation to suppression of the M/KCNQ-current were discovered. A key molecule is A-kinase anchoring protein (AKAP; AKAP79 in human, or its rat homolog, AKAP150) which forms a trimeric complex with protein kinase C (PKC) and KCNQ channels. AKAP79 or 150 serves as an adapter that brings the anchored C-kinase to the substrate KCNQ channel to permit the rapid and 'definitive' phosphorylation of serine residues, resulting in avoidance of signal dispersion. Thus, these findings suggest that mAChR-induced short-term modulation (or memory) does occur within the already well-integrated molecular complex, without accompanying Hebbian synapse plasticity. However, before this identity is confirmed, many other modulators which affect M-currents remain to be addressed as intriguing issues