Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

This study aimed to validate a wearable device’s walking speed estimation pipeline, considering complexity, speed, and walking bout duration. The goal was to provide recommendations on the use of wearable devices for real-world mobility analysis. Participants with Parkinson’s Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and healthy older adults (n = 97) were monitored in the laboratory and the real-world (2.5 h), using a lower back wearable device. Two walking speed estimation pipelines were validated across 4408/1298 (2.5 h/laboratory) detected walking bouts, compared to 4620/1365 bouts detected by a multi-sensor reference system. In the laboratory, the mean absolute error (MAE) and mean relative error (MRE) for walking speed estimation ranged from 0.06 to 0.12 m/s and − 2.1 to 14.4%, with ICCs (Intraclass correlation coefficients) between good (0.79) and excellent (0.91). Real-world MAE ranged from 0.09 to 0.13, MARE from 1.3 to 22.7%, with ICCs indicating moderate (0.57) to good (0.88) agreement. Lower errors were observed for cohorts without major gait impairments, less complex tasks, and longer walking bouts. The analytical pipelines demonstrated moderate to good accuracy in estimating walking speed. Accuracy depended on confounding factors, emphasizing the need for robust technical validation before clinical application. Trial registration: ISRCTN – 12246987

Morphogen\ue8se exp\ue9rimentale chez les Cili\ue9s: IV. Sur le r\uf4le de la Zone de Membranelles Adorales dans la r\ue9g\ue9n\ue9ration chez Stentor coeruleus

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Rationalizing the impact of aging on fiber–matrix interface and stability of cement-based composites submitted to carbonation at early ages

The objective of this work is to show the effect of carbonation at early stages on fiber–cement composites and impact on hydration, chemical and dimension stability. Carbonation increased the content of CaCO3 polymorphs and consumed Ca(OH)2 and other hydrated calcium phases. Micrographs and energydispersive spectrometry showed the CaCO3 formed is precipitated in the pore structure of the matrix, decreasing diffusion of Si, S, and Al during hydration. Therefore, a refining process of pore sizes is produced, and fiber–matrix interface in carbonated composites was improved, leading to volume stabilization of the composite, as indicated by lower drying shrinkage and lower porosity.Peer reviewe