An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs

Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of predicting the location of known TFBS motifs in a given DNA sequence. It has previously been shown that, when scoring matches to known TFBS motifs, interdependencies between positions within a motif should be taken into account. However, this remains a challenging task owing to the fact that sequences similar to those of known TFBSs can occur by chance with a relatively high frequency. Here we present a new method for matching sequences to TFBS motifs based on intuitionistic fuzzy sets (IFS) theory, an approach that has been shown to be particularly appropriate for tackling problems that embody a high degree of uncertainty. Results: We propose SCintuit, a new scoring method for measuring sequence-motif affinity based on IFS theory. Unlike existing methods that consider dependencies between positions, SCintuit is designed to prevent overestimation of less conserved positions of TFBSs. For a given pair of bases, SCintuit is computed not only as a function of their combined probability of occurrence, but also taking into account the individual importance of each single base at its corresponding position. We used SCintuit to identify known TFBSs in DNA sequences. Our method provides excellent results when dealing with both synthetic and real data, outperforming the sensitivity and the specificity of two existing methods in all the experiments we performed. Conclusions: The results show that SCintuit improves the prediction quality for TFs of the existing approaches without compromising sensitivity. In addition, we show how SCintuit can be successfully applied to real research problems. In this study the reliability of the IFS theory for motif discovery tasks is proven

ACADEMIC LIBRARY USERS’ EXPERIENCE: A REVIEW ON RELATED CONCEPTS AND EMPIRICAL IMPLICATION

In order to answer the questions raised to guide this study, there is need to review previous literature that relates to variables understudied. Also, to operationally define key concepts used for this study to ensure clarity of the concepts. Literature review shows a vibrant section and significant untouched materials to structure the infrastructure of a precise subject component in whichever category of a research study. It is conducted to obtain a clear consideration about the precise area of study. The literature review is arranged developing themes directly drawn from the literature, chronologically and thematically in this study. Researchers followed literature Review as the main methodology to review the existing empirical knowledge to build conceptual content to support for the proposed research directions. The findings provide the insights on how empirical findings being shared in literature reviews connecting the concept of Band Citizenship behavior and related concepts and implications. Based on the discussion, postulate the future research directions in line with the empirical knowledge gaps found within.  Article visualizations

EXAMINES ACADEMIC LIBRARY USERS’ EXPERIENCE TOWARDS LIBRARY PATRONAGE IN STATE UNIVERSITIES IN SRI LANKA

Libraries and information centers are service units held with the responsibility of providing varied information services based on a number of resources. It covers tangible assets, namely library building, equipment, furniture, information resources and staff. The intangible element has been the information services provided by the libraries. The tangible assets and intangible services of libraries are changing greatly due to the development and changes in the area of information technology. The purpose of this study is to empirically investigate to accomplish the relationship between Service Quality dimensions, customer experience (CE) library patronage (LP) and library user attitude (LUA) in the context of university library service quality in Sri Lanka. In addition, it investigates the mediating effect of customer experience in the relationship between dimensions of library service quality and the library patronage.  Article visualizations

Historical Evolution from Measuring Service Quality to Library User Experience:: A Conceptual Review of Related Concepts

Experience reflects customers’ overall assessment of value rather than in relation to expectations, highlighting the importance of these perceptual attributes. These attributes reflect customers’ higher-order objectives leading to purchasing behavior better than technical aspects of service do, the latter subject to frequent changes due to technology and competition. Therefore perceptual attributes are more stable as the focus of evaluation of experience SERVQUAL focuses largely upon customers’ assessment of the service process and human interactions Individual components of a service encounter may be assessed as ‘good quality’, but that does not automatically mean that the overall experience is judged high quality, nor does measuring the components of service quality ensure that customers achieve their desired outcomes

Development of Electronic Commerce Adoption Model based on Structural Equation Modeling Techniques

Advance Communication Technologies are playing a vital role in business today. In the world currently, many developing nations identified Small and Medium Scale organizations significantly important in counties2019; economic development. But the contribution from the SME sector is considerably low. Therefore, addressing this issue is important in business development. Among many reasons identified as barriers for SMEs to perform, studies have identified that low usage or not using technologies like E-commerce effected to this low performance. Therefore, studies are conducted to identify barriers to use technology in SMEs and many frameworks are tested and verified in different domains. In this study mainly tested and varied a framework which is considering Information Technological factors effecting the adoption of E-commerce technology and how it is effected for SME development. In this study framework is developed using literature analysis and hypothesis are developed based on past studies in terms of Information Technology factors as a main consideration. Model testing part is done using Structural Equation Molding using IBM AMOS. At the end of the study proposed framework is modified with statistical results and finally presented a framework which can be considered as a framework to understand the Information Technology factors effecting the E-commerce adoption and SME development

Association between nucleotide mutation of eNOS gene and serum level of vessel expansion factor (VEF) in non-smoker patients with vascular heart disease

Various mutation on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the expansion factor (VEF) and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C polymorphism of the gene or nucleotide mutation of eNOS gene in patients suffering from vascular heart disease (VHD) or coronary artery disease (CAD) in North West of Iran. 120 subjects including 60 patients with angiographically diagnosed CAD and 60 age and sex matched CAD-free subjects as control were studied. The levels of Nitric oxide in the samples were measured with the Griess method. The genotype studies were carried out using allele specific PCR. Comparing with the control reduced levels of NO were noticed in the patient group (P<0.05) and significantly high frequency of eNOs -786C genotype was found in CAD patients (P<0.05). The low levels of NO and increased frequency of T-786C polymorphism might be a risk factor in progression of coronary artery disease in the studied subjects.Keywords: Vascular heart disease, endothelial nitric oxide synthase gene, TC 786 SNP, vessel expansion factor (VEF), non-smokerAfrican Journal of Biotechnology Vol. 12(20), pp. 3023-302

HUMAN CAPITAL PRACTICES IMPACT ON ORGANIZATIONAL PERFORMANCE

Human Capital is embedded in individuals with intelligence, expertise, knowledge, skills and education pronouncement made by many scholars. There are different phenomena explained by Context Generic Human Capital (HC) and Specific Human Capital. Those organizations that plan, organized and manage HC strategically gain high Organizational Performance than those who don’t. HC revolves as a vital factor to win business competition in contemporary firms. HC can be distinguished as “General Human Capital” and “Specific Human Capital” whereas General HC may be utilized across jobs, firms and industries however Specific HC may be utilized for particular job or in a specific firm etc. The effective management integrates human capabilities to gain valuable, rare and inimitable practices consequently lead to Organizational Performance. The study results recorded a positive significance of Human Capital Practices on Organizational Performance.  Article visualizations