Entrepreneurship for Veterans with Disabilities: Lessons Learned from the Field

A 2009 research brief produced for the NTAR Leadership Center, a consortium led by the John H. Heldrich Center for Workforce Development at Rutgers, The State University of New Jersey. Founded in 2007 under a grant/contract with the Office of Disability Employment Policy at the U.S. Department of Labor, the NTAR Leadership Center's mission is to build capacity and leadership at the federal, state, and local levels to enable change across workforce development and disability-specific systems that will increase employment and economic self-sufficiency for adults with disabilities. This brief examines entrepreneurship as a viable option for veterans with disabilities, particularly those returning from the present-day conflicts in the Middle East. As entrepreneurs, veterans have an array of opportunities to customize their employment, accommodate their challenges, maximize their strengths and skills, and achieve their financial and career goals. This brief takes a close look at one program -- the Entrepreneurship Boot Camp -- and discusses some lessons learned from the operation of this program

Syntactic Complexity of R- and J-Trivial Regular Languages

The syntactic complexity of a regular language is the cardinality of its syntactic semigroup. The syntactic complexity of a subclass of the class of regular languages is the maximal syntactic complexity of languages in that class, taken as a function of the state complexity n of these languages. We study the syntactic complexity of R- and J-trivial regular languages, and prove that n! and floor of [e(n-1)!] are tight upper bounds for these languages, respectively. We also prove that 2^{n-1} is the tight upper bound on the state complexity of reversal of J-trivial regular languages.Comment: 17 pages, 5 figures, 1 tabl

Probing the formation of intermediate- to high-mass stars in protoclusters II. Comparison between millimeter interferometric observations of NGC 2264-C and SPH simulations of a collapsing clump

The earliest phases of massive star formation in clusters are still poorly understood. Here, we test the hypothesis for high-mass star formation proposed in our earlier paper (Peretto et al. 2006). In order to confirm the physical validity of this hypothesis, we carried out IRAM Plateau de Bure interferometer observations of NGC 2264-C and performed SPH numerical simulations of the collapse of a Jeans-unstable, prolate dense clump. Our Plateau de Bure observations reveal the presence of a new compact source (C-MM13) located only \~ 10000 AU away, but separated by ~ 1.1 km/s in (projected) velocity, from the most massive Class 0 object (C-MM3) lying at the very center of NGC 2264-C. Detailed comparison with our numerical SPH simulations supports the view that NGC 2264-C is an elongated cluster-forming clump in the process of collapsing and fragmenting along its long axis, leading to a strong dynamical interaction and possible protostar merger in the central region of the clump. The present study also sets several quantitative constraints on the initial conditions of large-scale collapse in NGC 2264-C. Our hydrodynamic simulations indicate that the observed velocity pattern characterizes an early phase of protocluster collapse which survives for an only short period of time (i.e., < 10^5 yr). To provide a good match to the observations the simulations require an initial ratio of turbulent to gravitational energy of only ~ 5 %, which strongly suggests that the NGC 2264-C clump is structured primarily by gravity rather than turbulence. The required "cold'' initial conditions may result from rapid compression by an external trigger.Comment: 15 pages, 8 figures, accepted for publication in A&

Seismic Coupling of Short-Period Wind Noise Through Mars’ Regolith for NASA’s InSight Lander

NASA’s InSight lander will deploy a tripod-mounted seismometer package onto the surface of Mars in late 2018. Mars is expected to have lower seismic activity than the Earth, so minimisation of environmental seismic noise will be critical for maximising observations of seismicity and scientific return from the mission. Therefore, the seismometers will be protected by a Wind and Thermal Shield (WTS), also mounted on a tripod. Nevertheless, wind impinging on the WTS will cause vibration noise, which will be transmitted to the seismometers through the regolith (soil). Here we use a 1:1-scale model of the seismometer and WTS, combined with field testing at two analogue sites in Iceland, to determine the transfer coefficient between the two tripods and quantify the proportion of WTS vibration noise transmitted through the regolith to the seismometers. The analogue sites had median grain sizes in the range 0.3–1.0 mm, surface densities of 1.3-1.8 gcm−3, and an effective regolith Young’s modulus of 2.5+1.9−1.4 MPa. At a seismic frequency of 5 Hz the measured transfer coefficients had values of 0.02–0.04 for the vertical component and 0.01–0.02 for the horizontal component. These values are 3–6 times lower than predicted by elastic theory and imply that at short periods the regolith displays significant anelastic behaviour. This will result in reduced short-period wind noise and increased signal-to-noise. We predict the noise induced by turbulent aerodynamic lift on the WTS at 5 Hz to be ∼2×10−10 ms−2 Hz−1/2 with a factor of 10 uncertainty. This is at least an order of magnitude lower than the InSight short-period seismometer noise floor of 10−8 ms−2 Hz−1/2

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4

Developing reading-writing connections; the impact of explicit instruction of literary devices on the quality of children's narrative writing

The purpose of this collaborative schools-university study was to investigate how the explicit instruction of literary devices during designated literacy sessions could improve the quality of children's narrative writing. A guiding question for the study was: Can children's writing can be enhanced by teachers drawing attention to the literary devices used by professional writers or “mentor authors”? The study was conducted with 18 teachers, working as research partners in nine elementary schools over one school year. The research group explored ways of developing children as reflective authors, able to draft and redraft writing in response to peer and teacher feedback. Daily literacy sessions were complemented by weekly writing workshops where students engaged in authorial activity and experienced writers' perspectives and readers' demands (Harwayne, 1992; May, 2004). Methods for data collection included video recording of peer-peer and teacher-led group discussions and audio recording of teacher-child conferences. Samples of children's narrative writing were collected and a comparison was made between the quality of their independent writing at the beginning and end of the research period. The research group documented the importance of peer-peer and teacher-student discourse in the development of children's metalanguage and awareness of audience. The study suggests that reading, discussing, and evaluating mentor texts can have a positive impact on the quality of children's independent writing

Concurrent validity and between-unit reliability of a foot-mounted inertial measurement unit to measure velocity during team sport activity

The concurrent validity and between-unit reliability of a foot-mounted inertial measurement unit (F-IMU) was investigated during linear and change of direction running drills. Sixteen individuals performed four repetitions of two drills (maximal acceleration and flying 10 m sprint) and five repetitions of a multi-directional movement protocol. Participants wore two F-IMUs (Playermaker) and 10 retro-reflective markers to allow for comparisons to the criterion system (Qualisys). Validity of the F-IMU derived velocity was assessed via root-mean-square error (RMSE), 95% limits of agreement (LoA) and mean difference with 95% confidence interval (CI). Between-unit reliability was assessed via intraclass correlation (ICC) with 90% CI and 95% LoA. The mean difference for instantaneous velocity for all participants and drills combined was −0.048 ± 0.581 m ∙ s −1, the LoA were from −1.09 to −1.186 m ∙ s −1 and RMSE was 0.583 m ∙ s −1. The ICC ranged from 0.84 to 1, with LoA from −7.412 to 2.924 m ∙ s −1. Differences were dependent on the reference speed, with the greatest absolute difference (−0.66 m ∙ s −1) found at velocities above 7 m ∙ s −1. Between-unit reliability of the F-IMU ranges from good to excellent for all locomotor characteristics. Playermaker has good agreement with 3D motion capture for velocity and good to excellent between-unit reliability.</p

A multi-club analysis of the locomotor training characteristics of elite female soccer players

Objective: Quantifying differences in locomotor characteristics of training between two competition levels and between training days within elite female soccer players. Methods: Foot-mounted inertial measurement unit (Playermaker) data were collected from 293 players from three Women’s Super League (WSL; n = 76) and eight Women’s Championship (WC; n = 217) teams over a 28-week period. Data were analysed using partial least squares correlation analysis to identify relative variable importance and linear mixed effects models to identify magnitude of effects. Results: WSL players performed more high-speed running distance (HSR; &gt;5.29 m∙s −1), sprint distance (SpD; &gt;6.26 m∙s −1), acceleration (ACC; &gt;3 m∙s −2) and deceleration (DEC; &lt;-3 m∙s −2) distance than WC players. The largest difference between WSL and WC in HSR and HSR per minute occurred on MD-4, (354.7 vs. 190.29 m and 2.8 vs. 1.7 m∙min −1). On MD-2, WSL players also covered greater SpD (44.66 vs. 12.42 m), SpD per minute (0.38 vs. 0.11 m∙min −1) and HSR per minute (1.67 vs. 0.93 m∙min −1). Between training days both WSL and WC teams reduced HSR and SpD but not ACC and DEC distance from MD-4 to MD-2, with MD-4 the highest training day of the week. Conclusion: MD-4 is a key training day discriminating between competitive level. HSR and SpD volume and intensity is tapered in WSL and WC players, however there is less clear taper of ACC or DEC. As such, WC teams could increase the volume and intensity of HSR on MD-4 to mimic locomotor activities of those at a higher standard.</p

Amenability of groups and GG-sets

This text surveys classical and recent results in the field of amenability of groups, from a combinatorial standpoint. It has served as the support of courses at the University of G\"ottingen and the \'Ecole Normale Sup\'erieure. The goals of the text are (1) to be as self-contained as possible, so as to serve as a good introduction for newcomers to the field; (2) to stress the use of combinatorial tools, in collaboration with functional analysis, probability etc., with discrete groups in focus; (3) to consider from the beginning the more general notion of amenable actions; (4) to describe recent classes of examples, and in particular groups acting on Cantor sets and topological full groups

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis

Lipid rafts are envisaged as lateral assemblies of specific lipids and proteins that dissociate and associate rapidly and form functional clusters in cell membranes. These structural platforms are not confined to the plasma membrane; indeed lipid microdomains are similarly formed at subcellular organelles, which include endoplasmic reticulum, Golgi and mitochondria, named raft-like microdomains. In addition, some components of raft-like microdomains are present within ER-mitochondria associated membranes. This review is focused on the role of mitochondrial raft-like microdomains in the regulation of cell apoptosis, since these microdomains may represent preferential sites where key reactions take place, regulating mitochondria hyperpolarization, fission-associated changes, megapore formation and release of apoptogenic factors. These structural platforms appear to modulate cytoplasmic pathways switching cell fate towards cell survival or death. Main insights on this issue derive from some pathological conditions in which alterations of microdomains structure or function can lead to severe alterations of cell activity and life span. In the light of the role played by raft-like microdomains to integrate apoptotic signals and in regulating mitochondrial dynamics, it is conceivable that these membrane structures may play a role in the mitochondrial alterations observed in some of the most common human neurodegenerative diseases, such as Amyotrophic lateral sclerosis, Huntington's chorea and prion-related diseases. These findings introduce an additional task for identifying new molecular target(s) of pharmacological agents in these pathologies