Open-String Actions and Noncommutativity Beyond the Large-B Limit

In the limit of large, constant B-field (the ``Seiberg-Witten limit''), the derivative expansion for open-superstring effective actions is naturally expressed in terms of the symmetric products *n. Here, we investigate corrections around the large-B limit, for Chern-Simons couplings on the brane and to quadratic order in gauge fields. We perform a boundary-state computation in the commutative theory, and compare it with the corresponding computation on the noncommutative side. These results are then used to examine the possible role of Wilson lines beyond the Seiberg-Witten limit. To quadratic order in fields, the entire tree-level amplitude is described by a metric-dependent deformation of the *2 product, which can be interpreted in terms of a deformed (non-associative) version of the Moyal * product.Comment: 30 pages, harvma

A deformation of AdS_5 x S^5

We analyse a one parameter family of supersymmetric solutions of type IIB supergravity that includes AdS_5 x S^5. For small values of the parameter the solutions are causally well-behaved, but beyond a critical value closed timelike curves (CTC's) appear. The solutions are holographically dual to N=4 supersymmetric Yang-Mills theory on a non-conformally flat background with non-vanishing R-currents. We compute the holographic energy-momentum tensor for the spacetime and show that it remains finite even when the CTC's appear. The solutions, as well as the uplift of some recently discovered AdS_5 black hole solutions, are shown to preserve precisely two supersymmetries.Comment: 16 pages, v2: typos corrected and references adde

Extremal single-charge small black holes: Entropy function analysis

We study stretched horizons of the type AdS_2 x S^8 for certain spherically symmetric extremal small black holes in type IIA carrying only D0-brane charge making use of Sen's entropy function formalism for higher derivative gravity. A scaling argument is given to show that the entropy of this class of black holes for large charge behaves as \sqrt{|q|} where q is the electric charge. The leading order result arises from IIA string loop corrections. We find that for solutions to exist the force on a probe D0-brane has to vanish and we prove that this feature persists to all higher derivative orders. We comment on the nature of the extremum of these solutions and on the sub-leading corrections to the entropy. The entropy of other small black holes related by dualities to our case is also discussed.Comment: 19 pages, v2:typos corrected and references adde

Global vegetation cover changes from coarse resolution satellite data

Land cover plays a key role in various biophysical processes related to global climate and terrestrial biogeochemistry. Although global land cover has dramatically changed over the last few centuries, until now there has been no consistent way of quantifying the changes globally. In this study we used long-term climate and soils data along with coarse resolution satellite observations to quantify the magnitude and spatial extent of large-scale land cover changes attributable to anthropogenic processes. Differences between potential leaf area index (LAI), derived from climate-soil-leaf area equilibrium, and actual leaf area index obtained from satellite data are used to estimate changes in land cover. Further, changes in LAI between potential and actual conditions are linked to climate by expressing them as possible changes in radiometric surface temperatures (Tr) resulting from changes in surface energy partitioning. As expected, areas with high population densities, such as India, China, and western Europe showed large reductions in LAI. Changes in global land cover expressed as summer, midafternoon Tr, ranged from −8° to +16°C. Deforestation resulted in an increase in Tr, while irrigated agriculture reduced the Tr. Many of the current general circulation models (GCMs) use potential vegetation maps to represent global vegetation. Our results indicate that there are widespread changes in global land cover due to deforestation and agriculture below the resolution of many GCMs, and these changes could have a significant impact on climate. Potential and actual LAI data sets are available for climate modelers at 0.5° × 0.5° resolution to study the possible impacts of land cover changes on global temperatures and circulation patterns

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.

α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the hallmark of Parkinson's disease (PD). The interaction between α-syn and lipid surfaces is believed to be a key feature for mediation of its normal function, but under other circumstances it is able to modulate amyloid fibril formation. Using a combination of experimental and theoretical approaches, we identify the mechanism through which facile aggregation of α-syn is induced under conditions where it binds a lipid bilayer, and we show that the rate of primary nucleation can be enhanced by three orders of magnitude or more under such conditions. These results reveal the key role that membrane interactions can have in triggering conversion of α-syn from its soluble state to the aggregated state that is associated with neurodegeneration and to its associated disease states.This work was supported by the UK BBSRC and the Wellcome Trust (CMD, TPJK, MV), the Frances and Augustus Newman Foundation (TPJK), Magdalene College, Cambridge (AKB) , St John’s College, Cambridge (TCTM), the Cambridge Home and EU Scholarship Scheme (GM), Elan Pharmaceuticals (CMD, TPJK, MV, CG) and the Leverhulme Trust (AKB).This is the accepted manuscript. The final version is available from NPG at http://www.nature.com/nchembio/journal/v11/n3/abs/nchembio.1750.htm

Post translational changes to α-synuclein control iron and dopamine trafficking : a concept for neuron vulnerability in Parkinson's disease

Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron content. α-Syn is a neuronal protein that is highly modified post-translationally and central to the Lewy body neuropathology of the disease. This review provides an overview of findings on the role post translational modifications to α-syn have in membrane binding and intracellular vesicle trafficking. Furthermore, we propose a concept in which acetylation and phosphorylation of α-syn modulate endocytic import of iron and vesicle transport of dopamine during normal physiology. Disregulated phosphorylation and oxidation of α-syn mediate iron and dopamine dependent oxidative stress through impaired cellular location and increase propensity for α-syn aggregation. The proposition highlights a connection between α-syn, iron and dopamine, three pathological components associated with disease progression in sporadic Parkinson's disease

Sensitivity of a general circulation model to global changes in leaf area index

Methods have recently become available for estimating the amount of leaf area at the surface of the Earth using satellite data. Also available are modeled estimates of what global leaf area patterns would look like should the vegetation be in equilibrium with current local climatic and soil conditions. The differences between the actual vegetation distribution and the potential vegetation distribution may reflect the impact of human activity on the Earth\u27s surface. To examine model sensitivity to changes in leaf area index (LAI), global distributions of maximum LAI were used as surface boundary conditions in the National Center for Atmospheric Research community climate model (NCAR CCM2) coupled with the biosphere atmosphere transfer scheme (BATS). Results from 10-year ensemble averages for the months of January and July indicate that the largest effects of the decreased LAI in the actual LAI simulation occur in the northern hemisphere winter at high latitudes despite the fact that direct LAI forcing is negligible in these regions at this time of year. This is possibly a result of LAI forcing in the tropics which has long-ranging effects in the winter of both hemispheres. An assessment of the Asian monsoon region for the month of July shows decreased latent heat flux from the surface, increased surface temperature, and decreased precipitation with the actual LAI distribution. While the statistical significance of the results has not been unambiguously established in these simulations, we suspect that an effect on modeled general circulation dynamics has occurred due to changes of maximum LAI suggesting that further attention needs to be paid to the accurate designation of vegetation parameters. The incorporation of concomitant changes in albedo, vegetation fractional coverage, and roughness length is suggested for further research

Relative climatic effects of landcover change and elevated carbon dioxide combined with aerosols: A comparison of model results and observations

In this study we examine the possibility that the historical total of human landcover changes have had a comparable effect on climate to that of historical increases in CO2 and aerosols. We compared results from two coupled climate model simulations which investigated transient climate changes produced by observed historical changes of CO2 combined with sulfate aerosol forcing with two other climate model simulations that examined the equilibrium climatic effects of currently observed changes in landcover from its natural state. We found that simulated, near-surface temperature anomalies due to transient increases in atmospheric CO2 combined with aerosols at the level currently observed are of similar amplitude as simulated temperature anomalies due to the direct and remote (nonlocal) equilibrium effects of historical anthropogenic landcover change in all models. Both effects are of comparable amplitude to observed temperature trends in the past 2 decades, the period of largest global surface warming. These results provide evidence for a confounding influence on surface temperatures and may be an indication that the problem of detection of the radiative warming effect of increased CO2 in the observational record may be more complicated than previously appreciated

Decadal variations in NDVI and food production in India

In this study we use long-term satellite, climate, and crop observations to document the spatial distribution of the recent stagnation in food grain production affecting the water-limited tropics (WLT), a region where 1.5 billion people live and depend on local agriculture that is constrained by chronic water shortages. Overall, our analysis shows that the recent stagnation in food production is corroborated by satellite data. The growth rate annually integrated vegetation greenness, a measure of crop growth, has declined significantly (p < 0.10) in 23% of the WLT cropland area during the last decade, while statistically significant increases in the growth rates account for less than 2%. In most countries, the decade-long declines appear to be primarily due to unsustainable crop management practices rather than climate alone. One quarter of the statistically significant declines are observed in India, which with the world’s largest population of food-insecure people and largest WLT croplands, is a leading example of the observed declines. Here we show geographically matching patterns of enhanced crop production and irrigation expansion with groundwater that have leveled off in the past decade. We estimate that, in the absence of irrigation, the enhancement in dry-season food grain production in India, during 1982–2002, would have required an increase in annual rainfall of at least 30% over almost half of the cropland area. This suggests that the past expansion of use of irrigation has not been sustainable. We expect that improved surface and groundwater management practices will be required to reverse the recent food grain production declines

Acute increase of alpha-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation

This work was supported by grants from the NIH/National Institute of Neurological Disorder and Stroke RO1 NS078165 (to J.R.M.), the Morton Cure Paralysis Fund (to J.R.M.), and the Branfman Family Foundation (to J.M.G.) and by a Dorothea Bennett graduate fellowship (to D.J.B.)