Conception and evaluation of a 3D musculoskeletal finite element foot model.

International audienceThis paper introduces a new patient-specific musculoskeletal and Finite Element (FE) model of the foot aimed to be used in the context of deep pressure ulcer prevention, orthopedic and motion analysis. This model is evaluated in both static and dynamic frameworks

Using genotyping-by-sequencing to understand Musa diversity

Poster presented at Plant and Animal Genome, PAG XXII. San Diego (USA), 11-15 Jan 201

Percolation properties of 3-D multiscale pore networks: how connectivity controls soil filtration processes

Quantifying the connectivity of pore networks is a key issue not only for modelling fluid flow and solute transport in porous media but also for assessing the ability of soil ecosystems to filter bacteria, viruses and any type of living microorganisms as well inert particles which pose a contamination risk. Straining is the main mechanical component of filtration processes: it is due to size effects, when a given soil retains a conveyed entity larger than the pores through which it is attempting to pass. We postulate that the range of sizes of entities which can be trapped inside soils has to be associated with the large range of scales involved in natural soil structures and that information on the pore size distribution has to be complemented by information on a critical filtration size (CFS) delimiting the transition between percolating and non percolating regimes in multiscale pore networks. We show that the mass fractal dimensions which are classically used in soil science to quantify scaling laws in observed pore size distributions can also be used to build 3-D multiscale models of pore networks exhibiting such a critical transition. We extend to the 3-D case a new theoretical approach recently developed to address the connectivity of 2-D fractal networks (Bird and Perrier, 2009). Theoretical arguments based on renormalisation functions provide insight into multi-scale connectivity and a first estimation of CFS. Numerical experiments on 3-D prefractal media confirm the qualitative theory. These results open the way towards a new methodology to estimate soil filtration efficiency from the construction of soil structural models to be calibrated on available multiscale data

Dehydration mechanism of a small molecular solid: 5-nitrouracil hydrate

Previous studies of the dehydration of 5-nitrouracil (5NU) have resulted in it being classified as a ‘‘channel hydrate’’ in which dehydration proceeds principally by the exit of the water molecules along channels in the structure. We have re-examined this proposal and found that in fact there are no continuous channels in the 5NU structure that would contribute to such a mechanism. Product water molecules would be immediately trapped in unlinked voids in the crystal structure and would require some additional mechanism to break loose from the crystal. Through a detailed structural analysis of the macro and micro structure of the 5NU as it dehydrates, we have developed a model for the dehydration process based on the observed development of structural defects in the 5NU crystal and the basic crystallography of the material. The model was tested against standard kinetic measurements and found to present a satisfactory account of kinetic observations, thus defining the mechanism. Overall, the study shows the necessity of complementing standard kinetic studies with a parallel macro and micro examination of the dehydrating material when evaluating the mechanisms of dehydration and decomposition processes

The HARPS search for southern extra-solar planets XXXV. Planetary systems and stellar activity of the M dwarfs GJ 3293, GJ 3341, and GJ 3543

Context. Planetary companions of a fixed mass induce larger amplitude reflex motions around lower-mass stars, which helps make M dwarfs excellent targets for extra-solar planet searches. State of the art velocimeters with $\sim$1m/s stability can detect very low-mass planets out to the habitable zone of these stars. Low-mass, small, planets are abundant around M dwarfs, and most known potentially habitable planets orbit one of these cool stars. Aims. Our M-dwarf radial velocity monitoring with HARPS on the ESO 3.6m telescope at La Silla observatory makes a major contribution to this sample. Methods. We present here dense radial velocity (RV) time series for three M dwarfs observed over $\sim5$ years: GJ 3293 (0.42M$_\odot$), GJ 3341 (0.47M$_\odot$), and GJ 3543 (0.45M$_\odot$). We extract those RVs through minimum $\chi^2$ matching of each spectrum against a high S/N ratio stack of all observed spectra for the same star. We then vet potential orbital signals against several stellar activity indicators, to disentangle the Keplerian variations induced by planets from the spurious signals which result from rotational modulation of stellar surface inhomogeneities and from activity cycles. Results. Two Neptune-mass planets - $msin(i)=1.4\pm0.1$ and $1.3\pm0.1M_{nept}$ - orbit GJ 3293 with periods $P=30.60\pm0.02$ d and $P=123.98\pm0.38$ d, possibly together with a super-Earth - $msin(i)\sim7.9\pm1.4M_\oplus$ - with period $P=48.14\pm0.12\;d$. A super-Earth - $msin(i)\sim6.1M_\oplus$ - orbits GJ 3341 with $P=14.207\pm0.007\;d$. The RV variations of GJ 3543, on the other hand, reflect its stellar activity rather than planetary signals.Comment: Accepted for publication in A&A, 19 pages, 12 figures, 7 table

«Smarter Medicine»: 5 Interventionen, die in der ambulanten allgemeinen inneren Medizin vermieden werden sollten

Seit 2012 befasst sich die Schweizerische Gesellschaft für Allgemeine Innere Medizin mit der Problematik der Überdiagnostik und Überversorgung in der Medizin. Nun hat sie beschlossen, eine Liste mit fünf Untersuchungen auf dem Gebiet der ambulanten allgemeinen inneren Medizin zusammenzustellen, die ohne oder mit nur geringem Nutzen bei zahlreichen Patienten durchgeführt werden, gleichzeitig jedoch unerwünschte Nebenwirkungen haben können und zum Anstieg der Gesundheitskosten beitragen

Development and characterization of a single particle laser ablation mass spectrometer (SPLAM) for organic aerosol studies

A single particle instrument was developed for real-time analysis of organic aerosol. This instrument, named Single Particle Laser Ablation Mass Spectrometry (SPLAM), samples particles using an aerodynamic lens system for which the theoretical performances were calculated. At the outlet of this system, particle detection and sizing are realized by using two continuous diode lasers operating at λ = 403 nm. Polystyrene Latex (PSL), sodium chloride (NaCl) and dioctylphtalate (DOP) particles were used to characterize and calibrate optical detection of SPLAM. The optical detection limit (DL) and detection efficiency (DE) were determined using size-selected DOP particles. The DE ranges from 0.1 to 90% for 100 and 350 nm DOP particles respectively and the SPLAM instrument is able to detect and size-resolve particles as small as 110–120 nm. During optical detection, particle scattered light from the two diode lasers, is detected by two photomultipliers and the detected signals are used to trigger UV excimer laser (λ = 248 nm) used for one-step laser desorption ionization (LDI) of individual aerosol particles. The formed ions are analyzed by a 1 m linear time-of-flight mass spectrometer in order to access to the chemical composition of individual particles. The TOF-MS detection limit for gaseous aromatic compounds was determined to be 0.85 × 10<sup>−15</sup> kg (∼4 × 10<sup>3</sup> molecules). DOP particles were also used to test the overall operation of the instrument. The analysis of a secondary organic aerosol, formed in a smog chamber by the ozonolysis of indene, is presented as a first application of the instrument. Single particle mass spectra were obtained with an effective hit rate of 8%. Some of these mass spectra were found to be very different from one particle to another possibly reflecting chemical differences within the investigated indene SOA particles. Our study shows that an exhaustive statistical analysis, over hundreds of particles, and adapted reference mass spectra are further needed to understand the chemical meaning of single particle mass spectra of chemically complex submicrometer-sized organic aerosols

The ELODIE and SOPHIE Search for Northern Extrasolar Planets: Jupiter-Analogs around Sun-Like Stars

We present radial-velocity measurements (RV) obtained in one of the numbers of programs underway to search for extrasolar planets with the spectrograph SOPHIE at the 1.93-m telescope of the Observatoire de Haute-Provence. Targets were selected from catalogs observed with ELODIE, which had been mounted previously at the telescope, in order to detect long-period planets with an extended database close to 15 year

The SOPHIE search for northern extrasolar planets VIII. A warm Neptune orbiting HD164595

High-precision radial velocity surveys explore the population of low-mass exoplanets orbiting bright stars. This allows accurately deriving their orbital parameters such as their occurrence rate and the statistical distribution of their properties. Based on this, models of planetary formation and evolution can be constrained. The SOPHIE spectrograph has been continuously improved in past years, and thanks to an appropriate correction of systematic instrumental drift, it is now reaching 2 m/s precision in radial velocity measurements on all timescales. As part of a dedicated radial velocity survey devoted to search for low-mass planets around a sample of 190 bright solar-type stars in the northern hemisphere, we report the detection of a warm Neptune with a minimum mass of 16.1 +- 2.7 Mearth orbiting the solar analog HD164595 in 40 +- 0.24 days . We also revised the parameters of the multiplanetary system around HD190360. We discuss this new detection in the context of the upcoming space mission CHEOPS, which is devoted to a transit search of bright stars harboring known exoplanets.Comment: 11 pages, 9 figure

Influence of the calcaneus shape on the risk of posterior heel ulcer using 3D patient-specific biomechanical modeling.

International audienceMost posterior heel ulcers are the consequence of inactivity and prolonged time lying down on the back. They appear when pressures applied on the heel create high internal strains and the soft tissues are compressed by the calcaneus. It is therefore important to monitor those strains to prevent heel pressure ulcers. Using a biomechanical lower leg model, we propose to estimate the influence of the patient-specific calcaneus shape on the strains within the foot and to determine if the risk of pressure ulceration is related to the variability of this shape. The biomechanical model is discretized using a 3D Finite Element mesh representing the soft tissues, separated into four domains implementing Neo Hookean materials with different elasticities: skin, fat, Achilles' tendon, and muscles. Bones are modelled as rigid bodies attached to the tissues. Simulations show that the shape of the calcaneus has an influence on the formation of pressure ulcers with a mean variation of the maximum strain over 6.0 percentage points over 18 distinct morphologies. Furthermore, the models confirm the influence of the cushion on which the leg is resting: a softer cushion leading to lower strains, it has less chances of creating a pressure ulcer. The methodology used for patient-specific strain estimation could be used for the prevention of heel ulcer when coupled with a pressure sensor