COCO: A Platform for Comparing Continuous Optimizers in a Black-Box Setting

We introduce COCO, an open source platform for Comparing Continuous Optimizers in a black-box setting. COCO aims at automatizing the tedious and repetitive task of benchmarking numerical optimization algorithms to the greatest possible extent. The platform and the underlying methodology allow to benchmark in the same framework deterministic and stochastic solvers for both single and multiobjective optimization. We present the rationales behind the (decade-long) development of the platform as a general proposition for guidelines towards better benchmarking. We detail underlying fundamental concepts of COCO such as the definition of a problem as a function instance, the underlying idea of instances, the use of target values, and runtime defined by the number of function calls as the central performance measure. Finally, we give a quick overview of the basic code structure and the currently available test suites.Comment: Optimization Methods and Software, Taylor & Francis, In press, pp.1-3

Alimentos contra el cáncer oral

El cáncer oral representa el 5% de todas las neoplasias y el 30% de los cánceres de cabeza y cuello. El porcentaje de supervivencia a los 5 años es de tan sólo el 25%, por lo que el diagnóstico y tratamiento precoces pueden salvar muchas vidas. La mayoría de los cánceres se relacionan con factores externos al organismo (tabaco, alcohol, betel, dieta y radiaciones solares, principalmente), que pueden modificarse o evitarse, es decir, prevenibles. Alrededor del 35% de los casos de cáncer están relacionados con la alimentación. Por este motivo, es importante que los profesionales de la salud informen a sus pacientes acerca de las enormes posibilidades profilácticas de la dieta. El objetivo de este trabajo de actualización bibliográfica es destacar la importancia de una alimentación saludable para la prevención del cáncer oral

L'usage des systèmes d'informations électroniques en recherche scientifique : le cas de la neurophysiologie.

Nous présentons les premiers résultats d'une enquête destinée à mieux connaître les pratiques de recherche d'information bibliographique et documentaire chez les chercheurs scientifiques. 64 chercheurs et étudiants doctorants en neurophysiologie ont répondu à un questionnaire portant sur les méthodes, les outils, et les objectifs des recherches d'information typiques dans leur activité. De plus, 11 personnes parmi les répondants ont participé à un entretien individuel semi structuré. Il en ressort que l'usage d'outils informatisés de recherche d'information bibliographique (RIB) est désormais pratique courante, au détriment des index et autres sources imprimées. Les principaux outils utilisés sont la base de données bibliographiques PubMed et le moteur de recherche Google, avec toutefois de nombreux autres outils plus spécifiques utilisés à titre complémentaire. Les répondants mentionnent des objectifs très variés, comme l'acquisition de connaissances nouvelles, mais aussi la recherche de techniques expérimentales, la veille documentaire, l'alimentation du débat scientifique, ou l'aide à l'enseignement. Les difficultés que rencontrent les experts en neurosciences intégratives dans l'exploitation des outils informatiques de RIB spécialisés semblent surtout liées à l'absence de formation des experts à ces outils. Les chercheurs définissent l'outil informatique de RIB « idéal » comme fiable et exhaustif, mais aussi rapide et facile à utiliser et apprendre . De fait, le facteur temps apparaît déterminant dans leur choix d'utilisation ou non d'un outil particulier. Cette étude ouvre la voie à des expériences plus spécifiques, qui porteront sur les stratégies cognitives des experts dans ce type de tâches

Espondilodiscitis en la infancia

La espondilodiscitis es una enfermedad inflamatoria que afecta el disco intervertebral y los cuerpos vertebrales adyacentes. Esta afección cursa con gran variedad de síntomas, relacionados con la edad del paciente y la localización del proceso inflamatorio. Se presentan 3 casos de discitis en niños pequeños que manifestaron síntomas diversos tales como: dificultad en la marcha, rechazo a caminar o sentarse, lumbalgia y dolor abdominal. Todos presentaron hiperlordosis lumbo-sacra. La centellografía resultó el examen complementario de elección para definir el diagnóstico al demostrar hipercaptación a nivel del disco intervertebral. La antibioticoterapia endovenosa fue curativa. Se propone al dosaje de proteína C reactiva como parámetro de laboratorio útil para el seguimiento.Spondylodiscitis is an inflammatory disease that affects the intervertebral disk and adjacent vertebral bodies. This affection develops a wide variety of symptoms related to the patient´s age and the inflammatory process location. We are reporting three children of early age with discitis who presented a range of symptoms such as: walking difficulties, refusal to walk or sit, low back pain and abdominal pain. Lumbosacral hyperlordosis was present in all cases. Scintigraphy was the complementary method of choice to define the diagnosis by showing hypercaptatation at the invertebral disk level. Endovenous antibiotic therapy proved effective. We propose the dosage of C protein as a useful laboratory parameter for the follow-up of these patients

A family of complex potentials with real spectrum

We consider a two-parameter non hermitean quantum-mechanical hamiltonian that is invariant under the combined effects of parity and time reversal transformation. Numerical investigation shows that for some values of the potential parameters the hamiltonian operator supports real eigenvalues and localized eigenfunctions. In contrast with other PT symmetric models, which require special integration paths in the complex plane, our model is integrable along a line parallel to the real axis.Comment: Six figures and four table

All functions are (locally) ss-harmonic (up to a small error) - and applications

The classical and the fractional Laplacians exhibit a number of similarities, but also some rather striking, and sometimes surprising, structural differences. A quite important example of these differences is that any function (regardless of its shape) can be locally approximated by functions with locally vanishing fractional Laplacian, as it was recently proved by Serena Dipierro, Ovidiu Savin and myself. This informal note is an exposition of this result and of some of its consequences

A Reilly formula and eigenvalue estimates for differential forms

We derive a Reilly-type formula for differential p-forms on a compact manifold with boundary and apply it to give a sharp lower bound of the spectrum of the Hodge Laplacian acting on differential forms of an embedded hypersurface of a Riemannian manifold. The equality case of our inequality gives rise to a number of rigidity results, when the geometry of the boundary has special properties and the domain is non-negatively curved. Finally we also obtain, as a by-product of our calculations, an upper bound of the first eigenvalue of the Hodge Laplacian when the ambient manifold supports non-trivial parallel forms.Comment: 22 page

Integrability and chaos: the classical uncertainty

In recent years there has been a considerable increase in the publishing of textbooks and monographs covering what was formerly known as random or irregular deterministic motion, now named by the more fashionable term of deterministic chaos. There is still substantial interest in a matter that is included in many graduate and even undergraduate courses on classical mechanics. Based on the Hamiltonian formalism, the main objective of this article is to provide, from the physicist's point of view, an overall and intuitive review of this broad subject (with some emphasis on the KAM theorem and the stability of planetary motions) which may be useful to both students and instructors.Comment: 24 pages, 10 figure

Benthic suspension feeders, key players in Antartic marine ecosystems?

Ja fa un cert temps que hom accepta, de manera general i a partir d'estudis de la columna d'aigua en mar obert, que en les comunitats marines de l'oceà Antàrtic hi ha un període prolongat d'activitat hivernal mínima que s'estén al llarg de sis mesos com a mínim, que és el temps que dura l'hivern austral. Tanmateix, investigacions recents en algunes espècies d'invertebrats suspensívors (filtradors) bentònics litorals han suggerit que el període d'inactivitat potser dura només unes poques setmanes. Això planteja una interessant qüestió: què és el que permet que aquests organismes antàrtics mengin, i per tant romanguin actius, durant períodes molt més llargs del que fins ara s'havia cregut? Hom ha suggerit adaptacions especials a menjar en concentracions molt baixes d'aliment, o bé a usar eficientment l'abundància ocasional d'aliment enmig de llargs períodes d'escassedat. Molts animals suspensívors podrien usar fonts alternatives al seu aliment usual, el fito- i el zooplàncton; per exemple, la ?fracció fina' de matèria orgànica, o microplàncton (bacteris, ciliats i flagel·lats, junt amb carboni inorgànic particulat d'orígens diversos), que hom ha demostrat recentment que té un paper molt més significatiu del que hom creia a l'hora de complementar la dieta i de subvenir a les demandes energètiques de moltes espècies de suspensívors. També s'ha esmentat el possible paper de la resuspensió de sediments i, atès l'elevat valor alimentari del component orgànic dels sediments antàrtics, àdhuc de fons pregons, serà interessant investigar més en aquesta línia. Observacions recents relacionades amb la dieta natural (captura de preses) d'algunes espècies d'aigües somes porten a suposar que alguns suspensívors antàrtics, si més no, tenen taxes de creixement i reproducció que són similars a les assenyalades per a espècies d'aigües temperades.For quite some time it was generally accepted, from water column and open sea studies, that in Antarctic marine communities there is a prolonged period of minimal winter activity which lasts for at least six months during the Southern winter. However, recent studies on certain littoral benthic suspension feeders have suggested that the period of inactivity may last only a few weeks. This raises the question of what allows these organisms to feed, and hence remain active, for considerably longer periods than previously thought. Special adaptations to feeding at low levels of food concentration, or to using occasional food abundance followed by long periods of starvation have been suggested. Many suspension feeders might use alternative food sources to phytoand zooplankton, e.g., the «fine fraction» of organic matter, or microplankton (bacteria, ciliates, and flagellates including POC of several origins), which has recently been shown to play a much more significant role than expected in complementing the diet and meeting energy demands in many species of suspension feeders. The possible role of sediment resuspension has also been reported, and given the high food value of the organic component of sediments even on deep bottoms further research would be of interest. Recent observations related to the natural diet (prey capture) of several shallow species lead to the assumption that part of Antarctic suspension feeders have similar growth and reproduction rates to those reported for temperate waters. Efficient food assimilation may contribute to our understanding of the continuous reproduction state observed in octocorals and, also, of the development of tridimensionally structured communities which are suspension-feeder dominated, highly diversified, and have a high biomass