Kek, Cucks, and God Emperor Trump: A Measurement Study of 4chan's Politically Incorrect Forum and its Effects on the Web

The discussion-board site 4chan has been part of the Internet's dark underbelly since its inception, and recent political events have put it increasingly in the spotlight. In particular, /pol/, the “Politically Incorrect'” board, has been a central figure in the outlandish 2016 US election season, as it has often been linked to the alt-right movement and its rhetoric of hate and racism. However, 4chan remains relatively unstudied by the scientific community: little is known about its user base, the content it generates, and how it affects other parts of the Web. In this paper, we start addressing this gap by analyzing /pol/ along several axes, using a dataset of over 8M posts we collected over two and a half months. First, we perform a general characterization, showing that /pol/ users are well distributed around the world and that 4chan's unique features encourage fresh discussions. We also analyze content, finding, for instance, that YouTube links and hate speech are predominant on /pol/. Overall, our analysis not only provides the first measurement study of /pol/, but also insight into online harassment and hate speech trends in social media

Hodgkin's lymphoma in remission after first-line therapy: which patients need FDG-PET/CT for follow-up?

Background: The purpose of the study was to evaluate the impact of 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) during follow-up of patients with Hodgkin's lymphoma. Patients and methods: Patients in complete remission or an unconfirmed complete remission after first-line therapy who received FDG-PET/CT during their follow-up were analyzed retrospectively. Confirmatory biopsy was mandatory in case of recurrence. Results: Overall, 134 patients were analyzed. Forty-two (31.3%) patients had a recurrence. The positive predictive value of FDG-PET/CT was 0.98. Single-factor analysis identified morphological residual mass [P = 0.0005, hazard ratio (HR) 3.4, 95% confidence interval (CI) 1.7-6.6] and symptoms (P 24 months). Conclusions: Asymptomatic patients without morphological residues and an early stage of disease do not need a routine FDG-PET/CT for follow-up. Asymptomatic patients with morphological residues should receive routine follow-up FDG-PET/CT for the first 24 months. Only patients with advanced initial stage do need a routine follow-up FDG-PET/CT beyond 24 month

Risk-adapted FDG-PET/CT-based follow-up in patients with diffuse large B-cell lymphoma after first-line therapy

Background: The purpose of this study was to evaluate the impact of 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) during follow-up of patients with diffuse large B-cell lymphoma (DLBCL) being in complete remission or unconfirmed complete remission after first-line therapy. Patients and methods: DLBCL patients receiving FDG-PET/CT during follow-up were analyzed retrospectively. Confirmatory biopsy was mandatory in cases of suspected disease recurrence. Results: Seventy-five patients were analyzed and 23 (30%) had disease recurrence. The positive predictive value (PPV) of FDG-PET/CT was 0.85. Patients >60 years [P = 0.036, hazard ratio (HR) = 3.82, 95% confidence interval (CI) 1.02-7.77] and patients with symptoms indicative of a relapse (P = 0.015; HR = 4.1; 95% CI 1.20-14.03) had a significantly higher risk for relapse. A risk score on the basis of signs of relapse, age >60 years, or a combination of these factors identified patients at high risk for recurrence (P = 0.041). Conclusions: FDG-PET/CT detects recurrent DLBCL after first-line therapy with high PPV. However, it should not be used routinely and if only in selected high-risk patients to reduce radiation burden and costs. On the basis of our retrospective data, FDG-PET/CT during follow-up is indicated for patients 60 years with and without clinical signs of relaps

Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland

The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of life. This development prompted a Swiss expert panel to re-evaluate the current status and formulate updated clinical recommendations for the diagnosis and treatment of plasma cell myeloma. These recommendations should help clinicians in their decision making to achieve the best outcome based on currently available data

RESPOND – A patient-centred program to prevent secondary falls in older people presenting to the emergency department with a fall: Protocol for a multi-centre randomised controlled trial

Introduction: Participation in falls prevention activities by older people following presentation to the Emergency Department (ED) with a fall is suboptimal. This randomised controlled trial (RCT) will test the RESPOND program which is designed to improve older persons’ participation in falls prevention activities through delivery of patient-centred education and behaviour change strategies. Design and setting: An RCT at two tertiary referral EDs in Melbourne and Perth, Australia. Participants: Five-hundred and twenty eight community-dwelling people aged 60-90 years presenting to the ED with a fall and discharged home will be recruited. People who: require an interpreter or hands-on assistance to walk; live in residential aged care or >50 kilometres from the trial hospital; have terminal illness, cognitive impairment, documented aggressive behaviour or history of psychosis; are receiving palliative care; or are unable to use a telephone will be excluded. Methods: Participants will be randomly allocated to the RESPOND intervention or standard care control group. RESPOND incorporates: (1) home-based risk factor assessment; (2) education, coaching, goal setting, and follow-up telephone support for management of one or more of four risk factors with evidence of effective intervention; and (3) healthcare provider communication and community linkage delivered over six months. Primary outcomes are falls and fall injuries per-person-year. Discussion: RESPOND builds on prior falls prevention learnings and aims to help individuals make guided decisions about how they will manage their falls risk. Patient-centred models have been successfully trialled in chronic and cardiovascular disease however evidence to support this approach in falls prevention is limited. Trial registration. The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000336684)

Studies on table grape germplasm grown in Northern Greece. I. Maturity time, bunch characteristics and yield

41 local and introduced table grape cultivars of the Greek Gene Bank in Thessaloniki were evaluated and documented with regard to 10 important morphological and viticultural characteristics, e.g. maturity time, bunch form and crop yield from 1991 tb 1993. The data indicate great variation within the grape germplasm in all characters and stress the importance of the genetic material as a donor of valuable genes for further grapevine improvement. Among the earliest cultivars is the Greek newbred Attiki (harvest time: end of July), while the local traditional Sideritis was shown to be the latest maturing cultivar (end of October). Principal Component Analysis (PCA) showed 3 factors representing 69.6% of the total variation. PC1, explaining 40.6% of the total variance, is highly correlated with time of maturity and crop yield. PC2, may be considered as the bunch size factor. The assessed cultivars were classified by cluster analysis into distinct groups, 2 of which contained all early and most of the late season cultivars

Fate of drugs during wastewater treatment

This is the post-print version of the final paper published in TrAC Trends in Analytical Chemistry. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2013 Elsevier B.V.Recent trends in the determination of pharmaceutical drugs in wastewaters focus on the development of rapid multi-residue methods. This review addresses recent analytical trends in drug determination in environmental matrices used to facilitate fate studies. Analytical requirements for further fate evaluation and tertiary process selection and optimization are also discussed.EPSRC, Northumbrian Water, Anglian Water, Severn Trent Water, Yorkshire Water, and United Utilities

Studies on table grape germplasm grown in Northern Greece. 2. Seedlessness, berry and must characteristics

From 1991 to 1993 nine quantitative and qualitative characteristics of the grape berry and its must were evaluated using local and introduced table grape cultivars of the grapevine collection of the Greek Gene Bank. The data indicate a distinct variation in the grape germplasm in all characters and demonstrate the usefulness of the genetic material as a donor of important genes for grapevine improvement. Principal Component Analysis (PCA) produced 2 factors representing 68.1% of the total variation. PC1, explaining 43.6% of the total variance, is highly correlated with berry size parameters and characteristics of the berry structure. By Cluster Analysis the assessed cultivars were separated into distinct groups; while seedlessness, was associated with small berry detachment force from the pedicel, late maturity was combined with high acid and low sugar content and a large number of seeds per berry was accompanied by low sugar content