Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice.

Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP). Because LTP is thought to be the cellular substrate for learning, we investigated whether mice lacking the GluR1 subunit [gria1 knock-outs (KO)] were capable of learning a simple cue-reward association, and whether such cues were able to influence motivated behavior. Both gria1 KO and wild-type mice learned to associate a light/tone stimulus with food delivery, as evidenced by their approaching the reward after presentation of the cue. During subsequent testing phases, gria1 KO mice also displayed normal approach to the cue in the absence of the reward (Pavlovian approach) and normal enhanced responding for the reward during cue presentations (Pavlovian to instrumental transfer). However, the cue did not act as a reward for learning a new behavior in the KO mice (conditioned reinforcement). This pattern of behavior is similar to that seen with lesions of the basolateral nucleus of the amygdala (BLA), and correspondingly, gria1 KO mice displayed impaired acquisition of responding under a second-order schedule. Thus, mice lacking the GluR1 receptor displayed a specific deficit in conditioned reward, suggesting that GluR1-containing AMPA receptors are important in the synaptic plasticity in the BLA that underlies conditioned reinforcement. Immunostaining for GluR2/3 subunits revealed changes in GluR2/3 expression in the gria1 KOs in the BLA but not the central nucleus of the amygdala (CA), consistent with the behavioral correlates of BLA but not CA function

Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake

Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects. Food-deprived male mice were given novel food during 30 min tests in a runway (FR group) that measured locomotor activity. Whereas the activity of this group increased with repeated testing, that of a group exposed to the runways but that received the food in the home cage (FH group), or of a group satiated by prefeeding before testing (SAT group), decreased. When exposed to the runways in the absence of food, the paired group was more active than the other groups (conditioned activity); no activity differences were seen in an alternative, non-food-paired, apparatus. Conditioned activity survived a 3-week period without runway exposure. Conditioned activity was selectively reduced by the opiate antagonist naltrexone (10-20 mg/kg) and by the noncompetitive AMPA receptor antagonist GYKI 52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] (5-10 mg/kg). The D1 antagonist SCH23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride] (15-30 microg/kg) and D2 antagonist sulpiride (25-125 mg/kg) reduced activity nonspecifically. A single intraperitoneal dose of cocaine (10 mg/kg) or morphine (20 mg/kg) increased activity compared with saline, the stimulant effect being larger in the FR group, suggesting "cross-sensitization" to these drugs. However, pretreatment with GYKI 52466 or naltrexone at doses that suppressed conditioned activity in FR animals suppressed cross-sensitization to cocaine. When allowed ad libitum access to food in the runway, FR mice consumed more pellets in a time-limited test. Thus, many of the features of behavioral sensitization to drugs can be demonstrated using food reward and may contribute to excessive eating

Linking academic emotions and student engagement: mature-aged distance students’ transition to university

This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Further and Higher Education on 2013, available online: https://www.tandfonline.com/doi/full/10.1080/0309877X.2014.895305Research into both student engagement and student emotions is increasing, with widespread agreement that both are critical determinants of student success in higher education. Less researched are the complex, reciprocal relationships between these important influences. Two theoretical frameworks inform this paper: Pekrun’s taxonomy of academic emotions and Kahu’s conceptual framework of student engagement. The prospective qualitative design aims to allow a rich understanding of the fluctuating and diverse emotions that students experience during the transition to university and to explore the relationships between academic emotions and student engagement. The study follows 19 mature-aged (aged 24 and over) distance students throughout their first semester at university, using video diaries to collect data on their emotional experiences and their engagement with their study. Pre and post-semester interviews were also conducted. Findings highlight that different emotions have different links to engagement: as important elements in emotional engagement, as inhibitors of engagement and as outcomes that reciprocally influence engagement. There are two key conclusions. First, student emotions are the point of intersection between the university factors such as course design and student variables such as motivation and background. Second, the flow of influence between emotions, engagement, and learning is reciprocal and complex and can spiral upwards towards ideal engagement or downwards towards disengagement and withdrawal.Publishe

Abundance of low energy (50-150 MeV) antiprotons in cosmic rays

The progress is presented of the nuclear emulsion experiment to determine abundance of low energy antiprotons in cosmic rays. No antiprotons have been detected so far at upper limit of p/p less than or similar to 4 x .0001 in the energy range 50 MeV to 15 MeV

Magnetic Braking and Viscous Damping of Differential Rotation in Cylindrical Stars

Differential rotation in stars generates toroidal magnetic fields whenever an initial seed poloidal field is present. The resulting magnetic stresses, along with viscosity, drive the star toward uniform rotation. This magnetic braking has important dynamical consequences in many astrophysical contexts. For example, merging binary neutron stars can form "hypermassive" remnants supported against collapse by differential rotation. The removal of this support by magnetic braking induces radial fluid motion, which can lead to delayed collapse of the remnant to a black hole. We explore the effects of magnetic braking and viscosity on the structure of a differentially rotating, compressible star, generalizing our earlier calculations for incompressible configurations. The star is idealized as a differentially rotating, infinite cylinder supported initially by a polytropic equation of state. The gas is assumed to be infinitely conducting and our calculations are performed in Newtonian gravitation. Though highly idealized, our model allows for the incorporation of magnetic fields, viscosity, compressibility, and shocks with minimal computational resources in a 1+1 dimensional Lagrangian MHD code. Our evolution calculations show that magnetic braking can lead to significant structural changes in a star, including quasistatic contraction of the core and ejection of matter in the outermost regions to form a wind or an ambient disk. These calculations serve as a prelude and a guide to more realistic MHD simulations in full 3+1 general relativity.Comment: 20 pages, 19 figures, 3 tables, AASTeX, accepted by Ap

Test of Nuclear Wave Functions for Pseudospin Symmetry

Using the fact that pseudospin is an approximate symmetry of the Dirac Hamiltonian with realistic scalar and vector mean fields, we derive the wave functions of the pseudospin partners of eigenstates of a realistic Dirac Hamiltonian and compare these wave functions with the wave functions of the Dirac eigenstates.Comment: 11 pages, 4 figures, minor changes in text and figures to conform with PRL requirement

The Kolmogorov-Smirnov test and its use for the identification of fireball fragmentation

We propose an application of the Kolmogorov-Smirnov test for rapidity distributions of individual events in ultrarelativistic heavy ion collisions. The test is particularly suitable to recognise non-statistical differences between the events. Thus when applied to a narrow centrality class it could indicate differences between events which would not be expected if all events evolve according to the same scenario. In particular, as an example we assume here a possible fragmentation of the fireball into smaller pieces at the quark/hadron phase transition. Quantitative studies are performed with a Monte Carlo model capable of simulating such a distribution of hadrons. We conclude that the Kolmogorov-Smirnov test is a very powerful tool for the identification of the fragmentation process.Comment: 9 pages, 10 figure