Chandra Observations of Radio-Loud Quasars at z > 4: X-rays from the Radio Beacons of the Early Universe

We present the results of Chandra observations of six radio-loud quasars (RLQs) and one optically bright radio-quiet quasar (RQQ) at z = 4.1-4.4. These observations cover a representative sample of RLQs with moderate radio-loudness (R ~ 40-400), filling the X-ray observational gap between optically selected RQQs and the five known blazars at z > 4 (R ~ 800-27000). We study the relationship between X-ray luminosity and radio-loudness for quasars at high redshift and constrain RLQ X-ray continuum emission and absorption. From a joint spectral fit of nine moderate-R RLQs observed by Chandra, we find tentative evidence for absorption above the Galactic N_H, with a best-fit neutral intrinsic column density of N_H = 2.4^{+2.0}_{-1.8} x 10^{22} cm^{-2}, consistent with earlier claims of increased absorption toward high-redshift RLQs. We also search for evidence of an enhanced jet-linked component in the X-ray emission due to the increased energy density of the cosmic microwave background (CMB) at high redshift, but we find neither spatial detections of X-ray jets nor a significant enhancement in the X-ray emission relative to comparable RLQs at low-to-moderate redshifts. Overall, the z ~ 4-5 RLQs have basic X-ray properties consistent with comparable RLQs in the local universe, suggesting that the accretion/jet mechanisms of these objects are similar as well.Comment: 12 pages, The Astronomical Journal, in pres

MIPS: The Multiband Imaging Photometer for SIRTF

The Multiband Imaging Photometer for SIRTF (MIPS) is to be designed to reach as closely as possible the fundamental sensitivity and angular resolution limits for SIRTF over the 3 to 700μm spectral region. It will use high performance photoconductive detectors from 3 to 200μm with integrating JFET amplifiers. From 200 to 700μm, the MIPS will use a bolometer cooled by an adiabatic demagnetization refrigerator. Over much of its operating range, the MIPS will make possible observations at and beyond the conventional Rayleigh diffraction limit of angular resolution

Nova Cygni 2001/2 = V2275 Cyg

We present an analysis of low- and medium resolution spectra of the very fast nova, Nova Cygni 2001/2 (V2275 Cyg) obtained at nine epochs in August, September and October, 2001. The expansion velocity from hydrogen Balmer lines is found to be 2100 km/s, although early H-alpha profile showed a weak feature at -3500 km/s, too. The overall appearance of the optical spectrum is dominated by broad lines of H, He and N, therefore, the star belongs to the ``He/N'' subclass of novae defined by Williams (1992). Interstellar lines and bands, as well as BV photometry taken from the literature yielded to a fairly high reddening of E(B-V)=1.0+/-0.1 mag. The visual light curve was used to deduce M_V by the maximum magnitude versus rate of decline relationship. The resulting parameters are: t_0=2452141.4(+0.1)(-0.5), t_2=2.9+/-0.5 days, t_3=7+/-1 days, M_V=-9.7+/-0.7 mag. Adopting these parameters, the star lies between 3 kpc and 8 kpc from the Sun.Comment: 5 pages, 5 figures, accepted for publication in A&

Emission Line Flickering from the Secondary Star in Cataclysmic Variables? A study of V3885 Sagitarii

Spectrophotometric observations of H-alpha and He I 6678 emission lines of the nova-like Cataclysmic Variable V3885 Sgr are presented and analyzed. The binary orbital period was determined as P = 0.20716071(22) days. Doppler Tomography was performed with both H-alpha and He I lines. Disc radial emissivity profiles were also computed. The tomography mapping of flickering sources was performed using the H-alpha line, from which we concluded that the flickering is not uniformly distributed on the disc. The observed tomogram of the flickering was compared with simulations, suggesting that the most intense flickering source in the H-alpha is not located in the accretion disc. It is proposed that the main line flickering source may be associated with the illuminated secondary star.Comment: 19 pages, 10 figures, 1 table. Accepted to be published on AJ. to donwload high resolution figures: http://www.astro.iag.usp.br/~fabiola/V3885_hires.pd

Infrared studies of the Be star X Per

Photometric and spectroscopic results are presented for the Be star X Per/HD 24534 from near-infrared monitoring in 2010-2011. The star is one of a sample of selected Be/X-ray binaries being monitored by us in the near-IR to study correlations between their X ray and near-IR behaviour. Comparison of the star's present near-IR magnitudes with earlier records shows the star to be currently in a prominently bright state with mean J, H, K magnitudes of 5.49, 5.33 and 5.06 respectively. The JHK spectra are dominated by emission lines of HeI and Paschen and Brackett lines of HI. Lines of OI 1.1287 and 1.3165 micron are also present and their relative strength indicates, since OI 1.1287 is stronger among the two lines, that Lyman beta fluorescence plays an important role in their excitation. Recombination analysis of the HI lines is done which shows that the Paschen and Brackett line strengths deviate considerably from case B predictions. These deviations are attributed to the lines being optically thick and this supposition is verified by calculating the line center optical depths predicted by recombination theory. Similar calculations indicate that the Pfund and Humphrey series lines should also be expected to be optically thick which is found to be consistent with observations reported in other studies. The spectral energy distribution of the star is constructed and shown to have an infrared excess. Based on the magnitude of the IR excess, which is modeled using a free-free contribution from the disc, the electron density in the disc is estimated and shown to be within the range of values expected in Be star discs.Comment: Accepted for publication in MNRAS, 7 pages, 6 figure

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate

Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction. Here, we investigated whether alpha(1)-adrenoceptors in the human prostate may activate extracellular signal-regulated kinases (ERK1/2). Methods: Prostate tissues from patients undergoing radical prostatectomy were stimulated in vitro. Activation of ERK1/2 was assessed by Western blot analysis. Expression of ERK1/2 was studied by immunohistochemistry. The effect of ERK1/2 inhibition by U0126 on phenylephrine-induced contraction was studied in organ-bath experiments. Results: Stimulation of human prostate tissue with noradrenaline (30 mu M) or phenylephrine (10 mu M) resulted in ERK activation. This was reflected by increased levels of phosphorylated ERK1/2. Expression of ERK1/2 in the prostate was observed in smooth muscle cells. Incubation of prostate tissue with U0126 (30 mu M) resulted in ERK1/2 inhibition. Dose-dependent phenylephrine-induced contraction of prostate tissue was not modulated by U0126. Conclusions: alpha(1)-Adrenoceptors in the human prostate are coupled to ERK1/2. This may partially explain previous observations suggesting a role of alpha(1)-adrenoceptors in the regulation of prostate growth. Copyright (C) 2011 S. Karger AG, Base

Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging

Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profiles of tissues and supports an objective investigation of tumour biology. In this study, various ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haematoxylin and eosin (H&E) stained images. The mass spectral data reveal tissue type-dependent lipid profiles which are consistent across the n = 110 samples (n = 107 patients) used in this study. Multivariate statistical methods were used to classify samples and identify molecular features discriminating between tissue types. Three main groups of samples (epithelial ovarian carcinoma, borderline ovarian tumours, normal ovarian stroma) were compared as were the carcinoma histotypes (serous, endometrioid, clear cell). Classification rates >84% were achieved for all analyses, and variables differing statistically between groups were determined and putatively identified. The changes noted in various lipid types help to provide a context in terms of tumour biochemistry. The classification of unseen samples demonstrates the capability of DESI-MSI to characterise ovarian samples and to overcome existing limitations in classical histopathology

A Super-Alfvenic Model of Dark Clouds

Supersonic random motions are observed in dark clouds and are traditionally interpreted as Alfven waves, but the possibility that these motions are super-Alfvenic has not been ruled out. In this work we report the results of numerical experiments in two opposite regimes; M_a ~ 1 and M_a >> 1, where M_a is the initial Alfvenic Mach number --the ratio of the rms velocity to the Alfven speed. Our results show that models with M_a >> 1 are consistent with the observed properties of molecular clouds that we have tested --statistics of extinction measurements, Zeeman splitting measurements of magnetic field strength, line width versus integrated antenna temperature of molecular emission line spectra, statistical B-n relation, and scatter in that relation-- while models with M_a ~ 1 have properties that are in conflict with the observations. We find that both the density and the magnetic field in molecular clouds may be very intermittent. The statistical distributions of magnetic field and gas density are related by a power law, with an index that decreases with time in experiments with decaying turbulence. After about one dynamical time it stabilizes at B ~ n^{0.4}. Magnetically dominated cores form early in the evolution, while later on the intermittency in the density field wins out, and also cores with weak field can be generated, by mass accretion along magnetic field lines.Comment: 10 figures, 2 tables include

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease

We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate susceptibility gene for AD. We investigated the possible effects of the CDC2 polymorphism on cerebrospinal fluid (CSF) biomarkers in AD patients. CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid (1-42) in AD patients and control individuals, and in relation to the amount of senile plaques and NFT in the frontal cortex and in the hippocampus in patients with autopsy-proven AD and controls. The CDC2 Ex6 + 7I allele was associated with a gene dose-dependent increase of CSF total tau levels (F-2,F- 626 = 7.0, p = 0.001) and the homozygous CDC2Ex6 +7II genotype was significantly more frequent among AD patients compared to controls (p = 0.006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD. Copyright (C) 2005 S. Karger AG, Basel