Running coupling constant of ten-flavor QCD with the Schr\"odinger functional method

Walking technicolor theory attempts to realize electroweak symmetry breaking as the spontaneous chiral symmetry breakdown caused by the gauge dynamics with slowly varying gauge coupling constant and large mass anomalous dimension. Many-flavor QCD is one of the candidates owning these features. We focus on the SU(3) gauge theory with ten flavors of massless fermions in the fundamental representation, and compute the gauge coupling constant in the Schr\"odinger functional scheme. Numerical simulation is performed with $O(a)$-unimproved lattice action, and the continuum limit is taken in linear in lattice spacing. We observe evidence that this theory possesses an infrared fixed point.Comment: 28 pages, 6 figures. v2) remarks on the continuum limit added, analysis simplified and done with more statistics, conclusion unchanged, version accepted for publication in PR

Validasi Metode Analisis Untuk Penetapan Kadar Tablet Asam Mefenamat Secara Spektrofotometri Ultraviolet

VALIDASI METODE ANALISIS UNTUK PENETAPAN KADAR TABLET ASAM MEFENAMAT SECARA SPEKTROFOTOMETRI ULTRAVIOLET Noviny Ramayany Uno1), Sri Sudewi1), Widya Astuty Lolo1) 1)Program Studi Farmasi FMIPA UNSRAT Manado, 95115 ABSTRACT The level of active substance is a requirement that must be met to ensure the quality of drugs, to make the determination of drug levels is needed a method that has been validated. This study aims to determine the validity and the levels of mefenamic acid in tablet dosage using UV spectrophotometry and determine the suitability of levels tablet mefenamic acid with trade name and generic with the requirement levels according to the Indonesian Pharmacopoeia fourth edition (1995). Its validity were tested based on the parameters of accuracy used standard addition method and precision parameters. Based on the results the linearity value was obtain r = 0.9979 with limits of detection (LOD) is 0.1246 ppm and limits of quantitation (LOQ) is 0.4154 ppm. The results showed levels of mefenamic acid in tablet dosage trade name (1) is 11.3580 ± 0.6344 ppm, trade names (2) is 11.3044 ± 0.4147 ppm, generic (1) is 11.3044 ± 0, 5664 ppm, generic (2) was 11.604 ± 0.4180 ppm. It showed mefenamic acid levels in tablet dosage generic and trade names fulfill level requirements contained in the Indonesian Pharmacopoeia fourth edition (1995). Keywords: Mefenamic acid, Method validation, UV spectrophotometry ABSTRAK Pemeriksaan kadar zat aktif merupakan persyaratan yang harus dipenuhi untuk menjamin kualitas sediaan obat, untuk melakukan penetapan kadar obat dibutuhkan suatu metode yang telah divalidasi. Penelitian ini bertujuan untuk menentukan validitas dan menentukan kadar asam mefenamat dalam sediaan tablet menggunakan metode spektrofotometri UV serta mengetahui kesesuaian kadar tablet asam mefenamat nama dagang dan generik dengan persyaratan kadar menurut Farmakope Indonesia Edisi IV (1995). Validitasnya diuji berdasarkan parameter akurasi dengan metode penambahan baku dan parameter ketelitian. Berdasarkan hasil diperoleh nilai linearitas sebesar r = 0,9979 dengan batas deteksi (LOD) 0,1246 ppm dan (LOQ) 0,4154 ppm. Hasil penelitian menunjukkan kadar asam mefenamat dalam sediaan tablet nama dagang (1) adalah 11,3580 ± 0,6344 ppm, nama dagang (2) adalah 11,3044 ± 0,4147 ppm, generik (1) adalah 11,3044 ± 0,5664 ppm, generik (2) adalah 11,604 ± 0,4180 ppm. Ini menunjukkan kadar asam mefenamat dalam sediaan tablet generik maupun nama dagang memenuhi persyaratan kadar yang tertera dalam Farmakope Indonesia Edisi IV (1995)

Theory of quasiballistic transport through nanocrystalline silicon dots

A model to describe the underlying physics of high-energy electron emission from a porous silicon diode is presented. The model is based on an atomistic tight-binding method combined with semiclassical Monte Carlo simulation. It well reproduces essential features of experimental findings. An initial acceleration region is shown to play a crucial role in generating quasiballistic electron emission

Electromagnetic mass splittings of the low lying hadrons and quark masses from 2+1 flavor lattice QCD+QED

Results are presented for the electromagnetic mass splittings of the low lying hadrons. These are used to determine the non-degenerate light quark masses. It is found that m_u=2.24(10)(34), m_d=4.65(15)(32), and $m_s=97.6(2.9)(5.5)$ MeV (MSbar scheme, 2 GeV scale). The first error is statistical and the second systematic. We find the lowest order electromagnetic splitting (m_pi+-m_pi0)_QED=3.38(23) MeV, the splittings including next-to-leading order, (m_pi+-m_pi0)_QED=4.50(23) MeV, (m_K+-m_K0)_QED=1.87(10) MeV, and the m_u != m_d contribution to the kaon mass difference, (m_K+-m_K0)_(m_u-m_d)=-5.840(96) MeV. All errors are statistical only, and the next-to-leading order pion splitting is only approximate; it does not contain all next-to-leading order contributions. We also computed the proton-neutron mass difference, including for the first time, QED interactions in a realistic 2+1 flavor calculation. We find $(m_p-m_n)_{\rm QED}=0.383(68)$ MeV, (m_p-m_n)_(m_u-m_d)=-2.51(14) MeV, and the total m_p-m_n=-2.13(16)(70) MeV, where the first error is statistical, and the second, part of the systematic error. We use domain wall fermions and the Iwasaki gauge action (gauge coupling beta=2.13). We use two lattice sizes, 16^3 and 24^3, to address finite volume effects. Non-compact QED is treated in the quenched approximation. We present new results for the electromagnetic low energy constants in SU(3) and SU(2) partially-quenched chiral perturbation theory to the next-to-leading order, obtained from fits to our data. Detailed analysis of systematic errors in our results and methods for improving them are discussed. Finally, new analytic results for SU(2)_L x SU(2)_R-plus-kaon chiral perturbation theory, including the one-loop logs proportional to alpha_em*m, are given.Comment: Significant additions: finite volume analysis of kaon mass (Sec. II and the Appendix) which is used to obtain new central values, extended discussion of the breaking of Dashen's theorem (VII), additional phenomenological results (VII), and a new section (VIII) on isospin breaking effects on the kaon decay constant. No conclusions or results from the first version changed significantl

The path inference filter: model-based low-latency map matching of probe vehicle data

We consider the problem of reconstructing vehicle trajectories from sparse sequences of GPS points, for which the sampling interval is between 10 seconds and 2 minutes. We introduce a new class of algorithms, called altogether path inference filter (PIF), that maps GPS data in real time, for a variety of trade-offs and scenarios, and with a high throughput. Numerous prior approaches in map-matching can be shown to be special cases of the path inference filter presented in this article. We present an efficient procedure for automatically training the filter on new data, with or without ground truth observations. The framework is evaluated on a large San Francisco taxi dataset and is shown to improve upon the current state of the art. This filter also provides insights about driving patterns of drivers. The path inference filter has been deployed at an industrial scale inside the Mobile Millennium traffic information system, and is used to map fleets of data in San Francisco, Sacramento, Stockholm and Porto.Comment: Preprint, 23 pages and 23 figure

Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient–derived cardiomyocytes

Duchenne muscular dystrophy (DMD)–associated cardiac diseases are emerging as a major cause of morbidity and mortality in DMD patients, and many therapies for treatment of skeletal muscle failed to improve cardiac function. The reprogramming of patients' somatic cells into pluripotent stem cells, combined with technologies for correcting the genetic defect, possesses great potential for the development of new treatments for genetic diseases. In this study, we obtained human cardiomyocytes from DMD patient–derived, induced pluripotent stem cells genetically corrected with a human artificial chromosome carrying the whole dystrophin genomic sequence. Stimulation by cytokines was combined with cell culturing on hydrogel with physiological stiffness, allowing an adhesion-dependent maturation and a proper dystrophin expression. The obtained cardiomyocytes showed remarkable sarcomeric organization of cardiac troponin T and α-actinin, expressed cardiac-specific markers, and displayed electrically induced calcium transients lasting less than 1 second. We demonstrated that the human artificial chromosome carrying the whole dystrophin genomic sequence is stably maintained throughout the cardiac differentiation process and that multiple promoters of the dystrophin gene are properly activated, driving expression of different isoforms. These dystrophic cardiomyocytes can be a valuable source for in vitro modeling of DMD-associated cardiac disease. Furthermore, the derivation of genetically corrected, patient-specific cardiomyocytes represents a step toward the development of innovative cell and gene therapy approaches for DMD