Quantum Key Distribution without sending a Quantum Signal

Quantum Key Distribution is a quantum communication technique in which random numbers are encoded on quantum systems, usually photons, and sent from one party, Alice, to another, Bob. Using the data sent via the quantum signals, supplemented by classical communication, it is possible for Alice and Bob to share an unconditionally secure secret key. This is not possible if only classical signals are sent. Whilst this last statement is a long standing result from quantum information theory it turns out only to be true in a non-relativistic setting. If relativistic quantum field theory is considered we show it is possible to distribute an unconditionally secure secret key without sending a quantum signal, instead harnessing the intrinsic entanglement between different regions of space time. The protocol is practical in free space given horizon technology and might be testable in principle in the near term using microwave technology

Quantum Communication with an Accelerated Partner

An unsolved problem in relativistic quantum information research is how to model efficient, directional quantum communication between localised parties in a fully quantum field theoretical framework. We propose a tractable approach to this problem based on solving the Heisenberg evolution of localized field observables. We illustrate our approach by analysing, and obtaining approximate analytical solutions to, the problem of communicating coherent states between an inertial sender, Alice and an accelerated receiver, Rob. We use these results to determine the efficiency with which continuous variable quantum key distribution could be carried out over such a communication channel.Comment: Additional explanatory text and typo in Eq.17 correcte

Patent Human Infections with the Whipworm, Trichuris trichiura, Are Not Associated with Alterations in the Faecal Microbiota

Background: The soil-transmitted helminth (STH), Trichuris trichiura colonises the human large intestine where it may modify inflammatory responses, an effect possibly mediated through alterations in the intestinal microbiota. We hypothesised that patent T. trichiura infections would be associated with altered faecal microbiota and that anthelmintic treatment would induce a microbiota resembling more closely that observed in uninfected individuals. Materials and Methods: School children in Ecuador were screened for STH infections and allocated to 3 groups: uninfected, T. trichiura only, and mixed infections with T. trichiura and Ascaris lumbricoides. A sample of uninfected children and those with T. trichiura infections only were given anthelmintic treatment. Bacterial community profiles in faecal samples were studied by 454 pyrosequencing of 16 S rRNA genes. Results: Microbiota analyses of faeces were done for 97 children: 30 were uninfected, 17 were infected with T. trichiura, and 50 with T. trichiura and A. lumbricoides. Post-treatment samples were analyzed for 14 children initially infected with T. trichiura alone and for 21 uninfected children. Treatment resulted in 100% cure of STH infections. Comparisons of the microbiota at different taxonomic levels showed no statistically significant differences in composition between uninfected children and those with T. trichiura infections. We observed a decreased proportional abundance of a few bacterial genera from the Clostridia class of Firmicutes and a reduced bacterial diversity among children with mixed infections compared to the other two groups, indicating a possible specific effect of A. lumbricoides infection. Anthelmintic treatment of children with T. trichiura did not alter faecal microbiota composition. Discussion: Our data indicate that patent human infections with T. trichiura may have no effect on faecal microbiota but that A. lumbricoides colonisation might be associated with a disturbed microbiota. Our results also catalogue the microbiota of rural Ecuadorians and indicate differences with individuals from more urban industrialised societies

Noiseless Linear Amplification and Distillation of Entanglement

The idea of signal amplification is ubiquitous in the control of physical systems, and the ultimate performance limit of amplifiers is set by quantum physics. Increasing the amplitude of an unknown quantum optical field, or more generally any harmonic oscillator state, must introduce noise. This linear amplification noise prevents the perfect copying of the quantum state, enforces quantum limits on communications and metrology, and is the physical mechanism that prevents the increase of entanglement via local operations. It is known that non-deterministic versions of ideal cloning and local entanglement increase (distillation) are allowed, suggesting the possibility of non-deterministic noiseless linear amplification. Here we introduce, and experimentally demonstrate, such a noiseless linear amplifier for continuous-variables states of the optical field, and use it to demonstrate entanglement distillation of field-mode entanglement. This simple but powerful circuit can form the basis of practical devices for enhancing quantum technologies. The idea of noiseless amplification unifies approaches to cloning and distillation, and will find applications in quantum metrology and communications.Comment: Submitted 10 June 200

P and Ca digestibility is increased in broiler diets supplemented with the high-phytase HIGHPHY wheat

Around 70% of total seed phosphorus is represented by phytate which must be hydrolysed to be bioavailable in non-ruminant diets. The limited endogenous phytase activity in non-ruminant animals make it common practice to add an exogenous phytase source to most poultry and pig feeds. The mature grain phytase activity (MGPA) of cereal seeds provides a route for the seeds themselves to contribute to phytate digestion, but MGPA varies considerably between species and most varieties in current use make negligible contributions. Currently, all phytases used for feed supplementation and transgenic improvement of MGPA are derived from microbial enzymes belonging to the group of histidine acid phosphatases (HAP). Cereals contain HAP phytases, but the bulk of MGPA can be attributed to phytases belonging to a completely different group of phosphatases, the purple acid phosphatases (PAPhy). In recent years, increased MGPAs were achieved in cisgenic barley holding extra copies of barley PAPhy and in the wheat HIGHPHY mutant, where MGPA was increased to ~6200 FTU/kg. In the present study, the effect of replacing 33%, 66% and 100% of a standard wheat with HIGHPHY wheat was compared with a control diet with and without 500 FTU of supplemental phytase. Diets were compared by evaluating broiler performance, ileal Ca and P digestibility and tibia development, using nine replicate pens of four birds per diet over 3 weeks from hatch. There were no differences between treatments in any tibia or bird performance parameters, indicating the control diet did not contain sufficiently low levels of phosphorus to distinguish effect of phytase addition. However, in a comparison of the two wheats, the ileal Ca and P digestibility coefficients for the 100% HIGHPHY wheat diets are 22.9% and 35.6% higher, respectively, than for the control diet, indicating the wheat PAPhy is functional in the broiler digestive tract. Furthermore, 33% HIGHPHY replacement of conventional wheat, significantly improved Ca and P digestibility over the diet-supplemented exogenous phytase, probably due to the higher phytase activity in the HIGHPHY diet (1804 v. 1150 FTU). Full replacement by HIGHPHY gave 14.6% and 22.8% higher ileal digestibility coefficients for Ca and P, respectively, than for feed supplemented with exogenous HAP phytase at 500 FTU. This indicates that in planta wheat PAPhys has promising potential for improving P and mineral digestibility in animal feed

Sharing Classical Secrets with Continuous Variable Entanglement Composable Security and Network Coding Advantage

Secret sharing is a multiparty cryptographic primitive that can be applied to a network of partially distrustful parties for encrypting data that is both sensitive it must remain secure and important it must not be lost or destroyed . When sharing classical secrets as opposed to quantum states , one can distinguish between protocols that leverage bipartite quantum key distribution QKD and those that exploit multipartite entanglement. The latter class are known to be vulnerable to so called participant attacks and, while progress has been made recently, there is currently no analysis that quantifies their performance in the composable, finite size regime, which has become the gold standard for QKD security. Given this and the fact that distributing multipartite entanglement is typically challenging one might well ask is there any virtue in pursuing multipartite entanglement based schemes? Here, we answer this question in the affirmative for a class of secret sharing protocols based on continuous variable graph states. We establish security in a composable framework and identify a network topology, specifically a bottleneck network of lossy channels, and parameter regimes within the reach of present day experiments for which a multipartite scheme outperforms the corresponding QKD based method in the asymptotic and finite size setting. Finally, we establish experimental parameters where the multipartite schemes outperform any possible QKD based protocol. This is one of the first concrete compelling examples of multipartite entangled resources achieving a genuine advantage over point to point protocols for quantum communication and represents a rigorous, operational benchmark to assess the usefulness of such resource

Harnessing symmetry protected topological order for quantum memories

Spin chains with symmetry protected edge modes are promising candidates to realize intrinsically robust physical qubits that can be used for the storage and processing of quantum information. In any experimental realization of such physical systems, weak perturbations in the form of induced interactions and disorder are unavoidable and can be detrimental to the stored information. At the same time, the latter may in fact be beneficial; for instance, by deliberately inducing disorder which causes the system to localize. We explore the potential of using an XZX cluster Hamiltonian to encode quantum information into the local edge modes and comprehensively investigate the influence of both many body interactions and disorder on their stability over time, adding substance to the narrative that many body localization may stabilize quantum information. We recover the edge state at each time step, allowing us to reconstruct the quantum channel that captures the locally constrained out of equilibrium time evolution. With this representation in hand, we analyze how well classical and quantum information are preserved over time as a function of disorder and interactions. We find that the performance of the edge qubits varies dramatically between disorder realizations. Whereas some show a smooth decoherence over time, a sizable fraction is rapidly rendered unusable as memories. We also find that the stability of the classical information a precursor for the usefulness of the chain as a quantum memory depends strongly on the direction in which the bit is encoded. When employing the chain as a genuine quantum memory, encoded qubits are most faithfully recovered for low interaction and high disorde

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells