DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.

Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized. Here, we describe the expression and ablation of DLC2 in mice using a reporter-knockout approach. DLC2 is expressed in several tissues and in endothelial cells (ECs) of blood vessels. Although ECs and blood vessels show no histological abnormalities and mice appear overall healthy, DLC2-mutant mice display enhanced angiogenic responses induced by matrigel and by tumor cells. Silencing of DLC2 in human ECs has reduced cell attachment, increased migration, and tube formation. These changes are rescued by silencing of RhoA, suggesting that the process is RhoA pathway dependent. These results indicate that DLC2 is not required for mouse development and normal vessel formation, but may protect mouse from unwanted angiogenesis induced by, for example, tumor cells

f(T)f(T) gravity after GW170817 and GRB170817A

The combined observation of GW170817 and its electromagnetic counterpart GRB170817A reveals that gravitational waves propagate at the speed of light in high precision. We apply the effective field theory approach to investigate the experimental consequences for the theory of $f(T)$ gravity. We find that the speed of gravitational waves within $f(T)$ gravity is exactly equal to the light speed, and hence the constraints from GW170817 and GRB170817A are trivially satisfied. The results are verified through the standard analysis of cosmological perturbations. Nevertheless, by examining the dispersion relation and the frequency of cosmological gravitational waves, we observe a deviation from the results of General Relativity, quantified by a new parameter. Although its value is relatively small in viable $f(T)$ models, its possible future measurement in advancing gravitational-wave astronomy would be the smoking gun of testing this type of modified gravity.Comment: 8 page

Black hole mass and accretion rate of active galactic nuclei with double-peaked broad emission lines

(Abridged) Using an empirical relation between the broad line region size and optical continuum luminosity, we estimated the black hole mass and accretion rate for 135 AGNs with double-peaked broad emission lines in two samples. With black hole masses from $3\times 10^7M_\odot$ to $5\times 10^9M_\odot$, these AGNs have the dimensionless accretion rates (Eddington ratios) between 0.001 and 0.1, and the bolometric luminosity between $10^{43}erg/s$ and $10^{46}erg/s$, both being significantly larger than those of several previously known low-luminosity double-peaked AGNs. The optical-X-ray spectra indices, $\alpha_{OX}$, of these high-luminosity double-peaked AGNs is between 1 and 1.9. Modest correlations of the $\alpha_{OX}$ value with the Eddington ratio and bolometric luminosity indicate that double-peaked AGNs with higher Eddington ratio or higher luminosity tend to have larger $\alpha_{OX}$ value. Therefore we suggested that the accretion process in some high-luminosity double-peaked AGNs is probably different from that of low-luminosity objects where an ADAF-like accretion flow was thought to exist. This is also supported by the presence of possible big blue bumps in the spectra of some double-peaked AGNs with higher Eddington ratios. We noticed that the prototype double-peaked emission line AGN, Arp 102B, may be an ``intermediate'' object between the high and low luminosity double-peaked AGNs. In addition, we found an apparent strong anti-correlation between the peak separation of double-peaked profile and Eddington ratio. If it is real, it may provide us a clue to understand why double-peaked broad emission lines were hardly found in luminous AGNs with Eddington ratio larger than 0.1.Comment: 24 pages, 6 figures, accepted by Ap

The black hole fundamental plane from a uniform sample of radio and X-ray emitting broad line AGNs

We derived the black hole fundamental plane relationship among the 1.4GHz radio luminosity (L_r), 0.1-2.4keV X-ray luminosity (L_X), and black hole mass (M) from a uniform broad line SDSS AGN sample including both radio loud and radio quiet X-ray emitting sources. We found in our sample that the fundamental plane relation has a very weak dependence on the black hole mass, and a tight correlation also exists between the Eddington luminosity scaled X-ray and radio luminosities for the radio quiet subsample. Additionally, we noticed that the radio quiet and radio loud AGNs have different power-law slopes in the radio--X-ray non-linear relationship. The radio loud sample displays a slope of 1.39, which seems consistent with the jet dominated X-ray model. However, it may also be partly due to the relativistic beaming effect. For radio quiet sample the slope of the radio--X-ray relationship is about 0.85, which is possibly consistent with the theoretical prediction from the accretion flow dominated X-ray model. We briefly discuss the reason why our derived relationship is different from some previous works and expect the future spectral studies in radio and X-ray bands on individual sources in our sample to confirm our result.Comment: 23 pages, 7 figures, ApJ accepte

A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Intrinsic disorder (i.e., lack of a unique 3-D structure) is a common phenomenon, and many biologically active proteins are disordered as a whole, or contain long disordered regions. These intrinsically disordered proteins/regions constitute a significant part of all proteomes, and their functional repertoire is complementary to functions of ordered proteins. In fact, intrinsic disorder represents an important driving force for many specific functions. An illustrative example of such disorder-centric functional class is RNA-binding proteins. In this study, we present the results of comprehensive bioinformatics analyses of the abundance and roles of intrinsic disorder in 3,411 ribosomal proteins from 32 species. We show that many ribosomal proteins are intrinsically disordered or hybrid proteins that contain ordered and disordered domains. Predicted globular domains of many ribosomal proteins contain noticeable regions of intrinsic disorder. We also show that disorder in ribosomal proteins has different characteristics compared to other proteins that interact with RNA and DNA including overall abundance, evolutionary conservation, and involvement in protein–protein interactions. Furthermore, intrinsic disorder is not only abundant in the ribosomal proteins, but we demonstrate that it is absolutely necessary for their various functions

Orientation and strain modulated electronic structures in puckered arsenene nanoribbons

Orthorhombic arsenene was recently predicted as an indirect bandgap semiconductor. Here, we demonstrate that nanostructuring arsenene into nanoribbons can successfully transform the bandgap to be direct. It is found that direct bandgaps hold for narrow armchair but wide zigzag nanoribbons, which is dominated by the competition between the in-plane and out-of-plane bondings. Moreover, straining the nanoribbons also induces a direct bandgap and simultaneously modulates effectively the transport property. The gap energy is largely enhanced by applying tensile strains to the armchair structures. In the zigzag ones, a tensile strain makes the effective mass of holes much higher while a compressive strain cause it much lower than that of electrons. Our results are crutial to understand and engineer the electronic properties of two dimensional materials beyond the planar ones like graphene

Strong electric fields induced on a sharp stellar boundary

Due to a first order phase transition, a compact star may have a discontinuous distribution of baryon as well as electric charge densities, as e.g. at the surface of a strange quark star. The induced separation of positive and negative charges may lead to generation of supercritical electric fields in the vicinity of such a discontinuity. We study this effect within a relativistic Thomas-Fermi approximation and demonstrate that the strength of the electric field depends strongly on the degree of sharpness of the surface. The influence of strong electric fields on the stability of compact stars is discussed. It is demonstrated that stable configurations appear only when the counter-pressure of degenerate fermions is taken into consideration.Comment: 13 pages, 2 figure