Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology.

The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain. Age-related changes in calcium levels and dynamics have the potential to increase the production and accumulation of both amyloid-beta peptide (Abeta) and tau pathologies in the AD brain, although these two pathologies themselves can induce calcium dyshomeostasis, particularly at synaptic membranes. This review discuses the evidence for a role for calcium dyshomeostasis in the initiation of pathology, as well as the evidence for these pathologies themselves disrupting normal calcium homeostasis, which lead to synaptic and neuronal dysfunction, synaptotoxicity and neuronal loss, underlying the dementia associated with the disease

GPS source solution of the 2004 Parkfield earthquake

We compute a series of finite-source parameter inversions of the fault rupture of the 2004 Parkfield earthquake based on 1 Hz GPS records only. We confirm that some of the co-seismic slip at shallow depth (<5 km) constrained by InSAR data processing results from early post-seismic deformation. We also show 1) that if located very close to the rupture, a GPS receiver can saturate while it remains possible to estimate the ground velocity (~1.2 m/s) near the fault, 2) that GPS waveforms inversions constrain that the slip distribution at depth even when GPS monuments are not located directly above the ruptured areas and 3) the slip distribution at depth from our best models agree with that recovered from strong motion data. The 95th percentile of the slip amplitudes for rupture velocities ranging from 2 to 5 km/s is, 55 +/- 6 cm.Comment: 24 pages including supp. material

Scalar Hair of Global Defect and Black Brane World

We consider a complex scalar field in (p+3)-dimensional bulk with a negative cosmological constant and study global vortices in two extra-dimensions. We reexamine carefully the coupled scalar and Einstein equations, and show that the boundary value of scalar amplitude at infinity of the extra-dimensions should be smaller than vacuum expectation value. The brane world has a cigar-like geometry with an exponentially decaying warp factor and a flat thick p-brane is embedded. Since a coordinate transformation identifies the obtained brane world as a black p-brane world bounded by a horizon, this strange boundary condition of the scalar amplitude is understood as existence of a short scalar hair.Comment: 26 pages, 2 figure

Cosmic D- and DF-strings from D3Dbar3: Black Strings and BPS Limit

We study D- and DF-strings in a D3${\bar {\rm D}}3$ system by using Dirac-Born-Infeld type action. In the presence of an electric flux from the transverse direction, we discuss gravitating thick D-string solutions of a spatial manifold, ${\rm S}^{2}\times {\rm R}^{1}$, in which straight D-strings stretched along the R${}^{1}$ direction are attached to the south and north poles of the two-sphere. There is a horizon along its equator, which means the structure of black strings is formed. We also discuss the BPS limit for thin parallel D- and DF-strings in both flat and curved spacetime. We obtain the BPS sum rule for an arbitrarily-separated multi-string configuration with a Gaussian type tachyon potential. At the site of each thin BPS D(F)-string, the pressure takes a finite value. We find that there exists a maximum deficit angle $\pi$ in the conical geometry induced by thin BPS D- and DF-strings.Comment: 24 pages, 5 figure

Inclusive angular distribution of alpha and Li fragments produced in the Fe-C and Fe-Pb collisions at 1.88 GeV/u

The LS (laboratory system) emission angles theta for 2188 and 298 Li fragments, produced inclusively in relativistic Fe-C and Fe-Pb collisions, have been measured in reference to incident Fe-ion beam tracks nearby in nuclear emulsion. An empirical differential frequency formula, dN(cot theta) = exp (a + b cot theta)d(cot theta) is obtained with the constant b approx. = -0.026 at 1.88 GeV/u, which seems to be independent on the kinds of target nucleus as well as on the kinds of projectile fragments

Ground-state structure of the hydrogen double vacancy on Pd(111)

We determine the ground-state structure of a double vacancy in a hydrogen monolayer on the Pd(111) surface. We represent the double vacancy as a triple vacancy containing one additional hydrogen atom. The potential-energy surface for a hydrogen atom moving in the triple vacancy is obtained by density-functional theory, and the wave function of the fully quantum hydrogen atom is obtained by solving the Schr\"odinger equation. We find that an H atom in a divacancy defect experiences significant quantum effects, and that the ground-state wave function is centered at the hcp site rather than the fcc site normally occupied by H atoms on Pd(111). Our results agree well with scanning tunneling microscopy images.Comment: 5 pages, 3 figure