Sensor Data Visualisation: A Composition-Based Approach to Support Domain Variability

International audienceIn the context of the Internet of Things, sensors are surrounding our environment. These small pieces of electronics are inserted in everyday life's elements (e.g., cars, doors, radiators, smartphones) and continuously collect information about their environment. One of the biggest challenges is to support the development of accurate monitoring dashboard to visualise such data. The one-size-fits-all paradigm does not apply in this context, as user's roles are variable and impact the way data should be visualised: a building manager does not need to work on the same data as classical users. This paper presents an approach based on model composition techniques to support the development of such monitoring dashboards, taking into account the domain variability. This variability is supported at both implementation and modelling levels. The results are validated on a case study named SmartCampus, involving sensors deployed in a real academic campus

Kapitel 28. Theorien des Wandels und der Gestaltung von Strukturen: Gesellschaftsperspektive

Die Gesellschaftsperspektive beschäftigt sich mit historisch entstandenen, tiefenwirksamen Treibern der Klimakrise. Ihr Fokus liegt auf klimaschädlichen Merkmalen von Natur-Mensch-Beziehungen, die für die westliche Moderne typisch und auch in Österreich wirksam sind. Dazu zählen Wachstumszwang, Kapitalakkumulation, dualistische Verständnisse von Natur und Mensch, Vorstellungen und Praktiken der Naturbeherrschung, sozial-ökologische Ungleichheit und disziplinäre Wissensproduktion

Kapitel 24. Theorien des Wandels und der Gestaltung von Strukturen

Abschnitt 5 nimmt eine Bestandsaufnahme von Theorien vor, die in einem weiten Sinne Wandel untersuchen. „Theorien des Wandels“ ist ein Überbegriff für all diejenigen Theorien, die helfen, aktuelle Dynamiken der Klimakrise zu verstehen und sowohl die stattfindenden als auch die notwendigen Transformationen zu fassen

Kapitel 2: Perspektiven zur Analyse und Gestaltung von Strukturen für ein klimafreundliches Leben

Kapitel 2 systematisiert entlang von vier Perspektiven in den Sozialwissenschaften weit verbreitete Theorien zur Analyse und Gestaltung von Strukturen klimafreundlichen Lebens. Das Kapitel möchte Leser_innen des Berichts bewusst machen, mit wie grundlegend unterschiedlichen Zugängen Forscher_innen Strukturen klimafreundlichen Lebens analysieren. Dies ist wichtig, um zu verstehen, dass es nie nur eine, sondern immer mehrere Perspektiven auf Strukturen klimafreundlichen Lebens gibt. Dieses Bewusstsein hilft, die Komplexität der Sozialwissenschaften und damit die Komplexität der Aufgabe – Strukturen für ein klimafreundliches Leben zu gestalten – zu erfassen. Unterschiedliche Zugänge zu sehen, bedeutet auch, ein besseres Verständnis von konfligierenden Problemdiagnosen, Zielhorizonten und Gestaltungsoptionen zu entwickeln und – idealerweise – damit umgehen zu können

Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity in isolated rat trachea.

PURPOSE: This study was designed to investigate the action of amitriptyline, a tricyclic antidepressant, on airway smooth muscle reactivity and its underlying mechanisms. METHODS: In isolated rat trachea, isometric force was recorded to examine the effects of amitriptyline on the contractile response to acetylcholine (ACh), electrical field stimulation (EFS), calyculin A (a myosin light chain phosphatase inhibitor), and sphingosylphosphorylcholine (SPC; a Rhokinase activator). In addition, inositol monophosphate (IP1) accumulation was measured to examine its effects on inositol 1, 4, 5-trisphosphate (IP(3)) production during stimulation with ACh. RESULTS: Amitriptyline inhibited the contractile responses to ACh, EFS, calyculin A, and SPC, with the concentrations of amitriptyline (mean +/- SD) required to exert 50% inhibition (IC(50)) being 4.3 +/- 1.3 microM, 3.2 +/- 1.6 microM, 256.4 +/- 106.4 microM, and 98.2 +/- 21.8 microM, respectively. In addition, amitriptyline (10 microM) eliminated the ACh (10 microM)-induced IP(1) accumulation. CONCLUSION: The results suggest that amitriptyline does not influence tracheal smooth muscle reactivity at clinical concentrations ( or =1 microM). The attenuated response to ACh brought about by amitriptyline is presumably due, at least in part, to the inhibition of phosphatidylinositol (PI) metabolism. The ability of amitriptyline to inhibit the calyculin Ainduced contraction suggests that amitriptyline also inhibits the Ca(2+)-calmodulin-myosin light chain pathway independently of the inhibition of PI metabolism. Finally, the difference between the IC(50) values for SPC-induced contraction and those for calyculin A-induced contraction suggests that amitriptyline may also inhibit the Rho-kinase pathway

Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope

We have determined that three type-specific and conformationally dependent monoclonal antibodies, H16.E70, H16.U4, and H16.V5, neutralize pseudotype human papillomavirus type 16 (HPV16) virions in vitro. H16.U4 and H16.V5 neutralized pseudotype virions derived from the German HPV16 variant 114K and the Zairian variant Z-1194 with equal efficiency. In contrast, neutralization of Z-1194 pseudotype virions by H16.E70 was two orders of magnitude weaker than neutralization of 114K pseudotype virions. This difference correlated with enzyme-linked immunosorbent assay reactivity of H16.E70 to L1 virus-like particles of the two variants. A substitution at residue 282 of L1 was responsible for this differential reactivity, suggesting that this residue constitutes part of the H16.E70 epitope.</jats:p

Capturing Privacy-preserving User Contexts with IndoorHash

International audienceIoT devices are ubiquitous and widely adopted by end-users to gather personal and environmental data that often need to be put into context in order to gain insights. In particular, location is often a critical context information that is required by third parties in order to analyse such data at scale. However, sharing this information is i) sensitive for the user privacy and ii) hard to capture when considering indoor environments.This paper therefore addresses the challenge of producing a new location hash, named IndoorHash, that captures the indoor location of a user, without disclosing the physical coordinates, thus preserving their privacy. This location hash leverages surrounding infrastructure, such as WiFi access points, to compute a key that uniquely identifies an indoor location.Location hashes are only known from users physically visiting these locations, thus enabling a new generation of privacy-preserving crowdsourcing mobile applications that protect from third parties re-identification attacks. We validate our results with a crowdsourcing campaign of 30 mobile devices during 4 weeks of data collection

Development and systematic evaluation of decellularization protocols in different application models for diaphragmatic tissue engineering

BACKGROUND: Tissue engineered bioscaffolds based on decellularized composites have gained increasing interest for treatment of various diaphragmatic impairments, including muscular atrophies and diaphragmatic hernias. Detergent-enzymatic treatment (DET) constitutes a standard strategy for diaphragmatic decellularization. However, there is scarce data on comparing DET protocols with different substances in distinct application models in their ability to maximize cellular removal while minimizing extracellular matrix (ECM) damage. METHODS: We decellularized diaphragms of male Sprague Dawley rats with 1 % or 0.1 % sodium dodecyl sulfate (SDS) and 4 % sodium deoxycholate (SDC) by orbital shaking (OS) or retrograde perfusion (RP) through the vena cava. We evaluated decellularized diaphragmatic samples by (1) quantitative analysis including DNA quantification and biomechanical testing, (2) qualitative and semiquantitative analysis by proteomics, as well as (3) qualitative assessment with macroscopic and microscopic evaluation by histological staining, immunohistochemistry and scanning electron microscopy. RESULTS: All protocols produced decellularized matrices with micro- and ultramorphologically intact architecture and adequate biomechanical performance with gradual differences. The proteomic profile of decellularized matrices contained a broad range of primal core and ECM-associated proteins similar to native muscle. While no outstanding preference for one singular protocol was determinable, SDS-treated samples showed slightly beneficial properties in comparison to SDC-processed counterparts. Both application modalities proved suitable for DET. CONCLUSION: DET with SDS or SDC via orbital shaking or retrograde perfusion constitute suitable methods to produce adequately decellularized matrices with characteristically preserved proteomic composition. Exposing compositional and functional specifics of variously treated grafts may enable establishing an ideal processing strategy to sustain valuable tissue characteristics and optimize consecutive recellularization. This aims to design an optimal bioscaffold for future transplantation in quantitative and qualitative diaphragmatic defects