8,055 research outputs found
Numerical modelling of multiple standing column wells for heating and cooling buildings
A model for simulating clusters of standing column wells (SCWs) for use in geothermal heating and cooling systems is described in this paper. The model is three-dimensional, dynamic and solves the governing equations using a finite volume discretisation scheme with a fully implicit algorithm. The slower-acting field equations are solved using a wider time interval than that used for the faster-acting well equations and the two sets of equations are coupled through the field equation source terms. A groundwater bleed feature is incorporated. The model is applied to two evaluative test cases the first of which involves heating only and the second, heating and cooling. Results of the applications suggest that SCWs can deliver substantially higher rates of heat transfer than conventional closed loop borehole heat exchanger arrays especially when groundwater bleed is operational. An important practical consequence of this is that far less geotechnical drilling is needed when using SCWs than is the case with closed loop arrays
Precision Astrometry with the Very Long Baseline Array: Parallaxes and Proper Motions for 14 Pulsars
Astrometry can bring powerful constraints to bear on a variety of scientific
questions about neutron stars, including their origins, astrophysics,
evolution, and environments. Using phase-referenced observations at the VLBA,
in conjunction with pulsar gating and in-beam calibration, we have measured the
parallaxes and proper motions for 14 pulsars. The smallest measured parallax in
our sample is 0.13+-0.02 mas for PSR B1541+09, which has a most probable
distance of 7.2+1.3-1.1 kpc. We detail our methods, including initial VLA
surveys to select candidates and find in-beam calibrators, VLBA
phase-referencing, pulsar gating, calibration, and data reduction. The use of
the bootstrap method to estimate astrometric uncertainties in the presence of
unmodeled systematic errors is also described. Based on our new
model-independent estimates for distance and transverse velocity, we
investigate the kinematics and birth sites of the pulsars and revisit models of
the Galactic electron density distribution. We find that young pulsars are
moving away from the Galactic plane, as expected, and that age estimates from
kinematics and pulsar spindown are generally in agreement, with certain notable
exceptions. Given its present trajectory, the pulsar B2045-16 was plausibly
born in the open cluster NGC 6604. For several high-latitude pulsars, the
NE2001 electron density model underestimates the parallax distances by a factor
of two, while in others the estimates agree with or are larger than the
parallax distances, suggesting that the interstellar medium is irregular on
relevant length scales. The VLBA astrometric results for the recycled pulsar
J1713+0747 are consistent with two independent estimates from pulse timing,
enabling a consistency check between the different reference frames.Comment: 16 pages, 9 figures, 4 tables; results unchanged; revised version
accepted by Ap
The role of mutation rate variation and genetic diversity in the architecture of human disease
Background
We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified.
Results
Consistent with our predictions we find that genes associated with Mendelian and complex disease are substantially longer than non-disease genes. However, we find that both Mendelian and complex disease genes are found in regions of the genome with relatively low mutation rates, as inferred from intron divergence between humans and chimpanzees, and they are predicted to have similar rates of non-synonymous mutation as other genes. Finally, we find that disease genes are in regions of significantly elevated genetic diversity, even when variation in the rate of mutation is controlled for. The effect is small nevertheless.
Conclusions
Our results suggest that gene length contributes to whether a gene is associated with disease. However, the mutation rate and the genetic architecture of the locus appear to play only a minor role in determining whether a gene is associated with disease
Rhomboid blepharoplasty and cryotherapy for the treatment of a squamous cell carcinoma on the lower eyelid in a horse
Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus.
Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. We compared the susceptibility of Aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. We found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosquitoes from an outbreak-prone region, particularly with respect to one dengue strain. These findings suggest recent evolution of population-based differences in vector competence or different historical origins. Future genomic comparisons of these populations could reveal the genetic basis of vector competence and the relative role of selection and stochastic processes in shaping their differences. Lastly, we show the novel finding of a correlation between midgut dengue titer and titer in tissues colonized after dissemination
Justice at Sea: Fishers’ politics and marine conservation in coastal Odisha, India
This is a paper about the politics of fishing rights in and around the Gahirmatha marine sanctuary in coastal Odisha, in eastern India. Claims to the resources of this sanctuary are politicised through the creation of a particularly damaging narrative by influential Odiya environmental actors about Bengalis, as illegal immigrants who have hurt the ecosystem through their fishing practices. Anchored within a theoretical framework of justice as recognition, the paper considers the making of a regional Odiya environmentalism that is, potentially, deeply exclusionary. It details how an argument about ‘illegal Bengalis’ depriving ‘indigenous Odiyas’ of their legitimate ‘traditional fishing rights’ derives from particular notions of indigeneity and territory. But the paper also shows that such environmentalism is tenuous, and fits uneasily with the everyday social landscape of fishing in coastal Odisha. It concludes that a wider class conflict between small fishers and the state over a sanctuary sets the context in which questions about legitimate resource rights are raised, sometimes with important effects, like when out at sea
Re-visiting the relations: Galactic thin disc age-velocity dispersion relation
The velocity dispersion of stars in the solar neighbourhood thin disc
increases with time after star formation. Nordstrom et al. (2004) is the most
recent observational attempt to constrain the age-velocity dispersion relation.
They fitted the age-velocity dispersion relations of each Galactic cardinal
direction space velocity component, U (towards the Galactic centre), V (in the
direction of Galactic rotation) and W (towards the North Galactic Pole), with
power laws and interpreted these as evidence for continuous heating of the disc
in all directions throughout its lifetime. We re-visit these relations with
their data and use Famaey et al. (2005) to show that structure in the local
velocity distribution function distorts the in-plane (U and V) velocity
distributions away from Gaussian so that a dispersion is not an adequate
parametrization of their functions. The age-sigma(W) relation can however be
constrained because the sample is well phase-mixed vertically. We do not find
any local signature of the stellar warp in the Galactic disc. Vertical disc
heating does not saturate at an early stage. Our new result is that a power law
is not required by the data: disc heating models that saturate after ~ 4.5 Gyr
are equally consistent with observations.Comment: Accepted for publication in MNRAS, 24 pages, 20 figure
Point-contact spectroscopy on URuSi
Tunnel and point contact experiments have been made in a URuSi single
crystal along the c-axis. The experiments were performed changing temperature
and contact size in a low temperature scanning tunneling microscope. A
resonance develops at the Fermi level at K. This resonance splits
and becomes asymmetric when the 17.5 K phase transition is crossed. These
results are consistent with the existence of Kondo like bound states of the
U ionic configurations and the conduction electrons. Below the
transition, these configurations are split by the development of quadrupolar
ordering. The peak separation can be interpreted as a direct measurement of the
order parameter. Measurements on a policrystalline UAu_2Si_2$ sample are also
reported, with a comparative study of the behavior of both materials.Comment: 4 pages (Latex) + 2 postscript figure
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