Selective Laser Sintering as a Rapid Prototyping and Manufacturing Technique

With accelerating growth and competition in today's global marketplace, manufacturers face the daunting tasks of meeting changing market needs, maintaining market share, and reasserting a technological edge. Now, more than ever, adopting new technologies is a key component in ensuring the successful outcome of new projects--and in producing longterm market success.Mechanical Engineerin

Verification of Query Completeness over Processes [Extended Version]

Data completeness is an essential aspect of data quality, and has in turn a huge impact on the effective management of companies. For example, statistics are computed and audits are conducted in companies by implicitly placing the strong assumption that the analysed data are complete. In this work, we are interested in studying the problem of completeness of data produced by business processes, to the aim of automatically assessing whether a given database query can be answered with complete information in a certain state of the process. We formalize so-called quality-aware processes that create data in the real world and store it in the company's information system possibly at a later point.Comment: Extended version of a paper that was submitted to BPM 201

Query Stability in Monotonic Data-Aware Business Processes [Extended Version]

Organizations continuously accumulate data, often according to some business processes. If one poses a query over such data for decision support, it is important to know whether the query is stable, that is, whether the answers will stay the same or may change in the future because business processes may add further data. We investigate query stability for conjunctive queries. To this end, we define a formalism that combines an explicit representation of the control flow of a process with a specification of how data is read and inserted into the database. We consider different restrictions of the process model and the state of the system, such as negation in conditions, cyclic executions, read access to written data, presence of pending process instances, and the possibility to start fresh process instances. We identify for which facet combinations stability of conjunctive queries is decidable and provide encodings into variants of Datalog that are optimal with respect to the worst-case complexity of the problem.Comment: This report is the extended version of a paper accepted at the 19th International Conference on Database Theory (ICDT 2016), March 15-18, 2016 - Bordeaux, Franc

Tryptophan research in panic disorder.

A considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder. Research on pathways and functions of tryptophan, an essential amino acid converted into serotonin, may advance our understanding of serotonergic actions in panic disorder and related phenomena. The investigative approaches in this field include manipulations of tryptophan availability as well as genetic association and functional brain imaging studies. In this review we examine the principle findings of these studies and propose further research directions

Wind tunnel tests of Space Shuttle external tank insulation material in the aerothermal tunnel at elevated (1440 deg F) total temperatures

Tests of the space shuttle external tank foam insulation were conducted in the von Karman Gas Dynamics Facility Tunnel C. For these tests, Tunnel C was run at Mach 4 with a total temperature of 1440 F and a total pressure which varied from 30-100 psia. Cold wall heating rates were changed by varying the test article support wedge angle and by adding and removing a shock generator or a cylindrical protuberance. Selected results are presented to illustrate the test techniques and typical data obtained

The hardest part is knowing I will survive: The use of music and creative mediums to enhance empathy and facilitate life-long distance learning in professionally qualified clinicians

© Redfame Publishing Inc.Music is an experience that can cross personal and professional domains alongside cultural, gender, age and generational boundaries; it can also enhance the learning process through emotional processing and connection. This paper focuses on the learning experience of qualified clinical psychologists (CPs) working in the United Kingdom. This group of CPs had experience of undertaking experiential learning and reflective writing during their professional training. It considers the potential to continue a learning process, 3 years post qualification, through long distance methods using vignette-based material. Empathising with, and understanding, the position of others from differing backgrounds is an important competency within the therapeutic work of CPs and this comes alongside acknowledging and understanding ones‟ own experiences, both past and present. CPs work with difficult life experiences and complex issues; connecting constantly can be exhausting and, perhaps, unrealistic. Yet, to truly empathise one must connect with, and understand, the lived experiences of others. We will consider what helps and hinders this process, and how music and other creative mediums can be effectively used in learning even via long distance methods. We will further consider how CPs may be well placed to enhance the learning about, and processing of, difficult emotional experiences for themselves, other clinicians and the people they might work with.Peer reviewe

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men

We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men. Subjects received 20mg vortioxetine, 40mg vortioxetine, 20mg paroxetine or placebo for three consecutive days in four different periods with at least three weeks between them. Polysomnography and blood sampling for pharmacokinetic analysis were performed on the pre-dose night and nights 1 and 3 of dosing in each period. Plasma concentrations of vortioxetine and paroxetine during the polysomnography measurement were used to estimate SERT occupancies using published relationships in healthy subjects. All three active treatments significantly increased REM onset latency and decreased time spent in REM sleep. In the pharmacokinetic/pharmacodynamics analysis significant relationships were found between REM onset latency and time spent in REM sleep and vortioxetine/paroxetine exposure. The relation between REM suppression parameters and SERT occupancy was significantly different between vortioxetine and paroxetine, despite the same SERT occupancy. This indicates that vortioxetine has a different clinical pharmacological profile from paroxetine, which may explain the differences in adverse effect profile of the two drugs, for instance the lower incidence of nausea, weight gain and sexual dysfunction with vortioxetine

Falterbeobachtungen an einen [einem] Teilstück der B 252 im Kreis Höxter

Tote Tiere am Straßenrand, besonders Kröten, Igel und Hasen, gehören heute schon zum alltäglichen Bild. Zu den häufigsten Tieren, die dem Straßenverkehr zum Opfer fallen, zählen die Insekten. Wer ein Auto besitzt, weiß selbst, wie viele Tiere an der Windschutzscheibe und am Kühlergrill haften bleiben. Da ich selbst bei meinen Beobachtungen an Straßenrändern immer wieder tote Falter fand, kam mir Anfang Mai des Jahres 1983 die Idee, diese Falter aufzusammeln und die Funde auszuwerten

“Here’s a Little Something for You”: How Therapists Respond to Client Gifts

Descriptions by 12 therapists of their experiences receiving tangible gifts from clients are examined. Using consensual qualitative research (C. E. Hill, B. J. Thompson, & E. N. Williams, 1997) therapists’ overall gift encounters and specifically identified gift events were explored. Results indicated that although clients rarely gave gifts, all of the participants had accepted gifts. Problematic gifts (i.e., ones that raised concern for therapists) were given at more provocative times than were unproblematic gifts (i.e., ones that evoked few concerns for therapists). Both types of gifts were given for various reasons (e.g., appreciation, manipulation, equalization). Participants reported positive and negative internal responses to both types of gifts, but more often discussed unproblematic than problematic gifts with clients. Problematic gifts were more often discussed with others than were unproblematic gifts. Gift episodes of both types facilitated therapy process