Serotonin Concentrations in Plasma and Variations During the Menstrual Cycle

Abstract We used a specific and sensitive radioenzymatic method to establish a reference interval for the concentration of serotonin in platelet-poor plasma in 98 healthy volunteers (49 men, 49 women). The interval was 0-11 nmol/L with a median of 2.8 nmol/L. No difference in concentration in relation to sex or age was observed. In a group of eight very old volunteers (ages 86-92 years), however, concentrations were increased. In addition, we monitored the plasma concentrations of serotonin in 20 healthy women (ages 26-45 years) through two menstrual cycles. Periovulatory and premenstrual concentrations were greater than the serotonin concentration at the start of menstruation.</jats:p

NSAID visar övertygande effekt vid postoperativ smärta

Non-steroidal antiinflammatory drugs (NSAID) are increasingly being included in the management of postoperative pain as part of a multimodal therapeutic approach. However, there is an ongoing debate among clinicians as to the perioperative use of NSAID's as many authors have cautioned against their use in this setting. Concerns about their impact on coagulation and renal function as well as a risk for gastrointestinal bleeding have been raised. However, many of the adverse effects reported have occurred during long term treatment and might not be directly applicable to the perioperative period. Still the clinician must be aware of the potential risks and benefits of these drugs. This review focuses on the pro's and con's of perioperative NSAID usage. We address the background for a multimodal approach to postoperative pain relief as well as potential alternatives to NSAID's and the recently introduced COX2-selective inhibitors

Effect of Music on Vital Signs and Postoperative Pain

Pharmacological methods to improve postoperative pain are well documented, but an increasing interest in nonpharmacological methods has stimulated research in this field. Traditional and pharmacological interventions to relieve perioperative anxiety and pain are being challenged by an increasing demand for more holistic approaches. This study tested the hypothesis that listening to music preoperatively and postoperatively would affect patients\u27 experience of pain, nausea, and well-being and have an impact on their vital signs. The authors conclude that a period of peaceful rest before and after surgery reduces patient anxiety

Parkinsons sjukdom : en utmaning för anestesiologen

                                                        Andelen äldre ökar i populationen, och härav följer att ett ökande antal patienter med Parkinsons sjukdom kommer att genomgå operation och anestesi.  Parkinsonpatienter behandlas med farmaka som potentiellt interagerar med perioperativt använda läkemedel.  Abrupt perioperativ utsättning av antiparkinsonläkemedel ökar risken för försämring av grundsjukdomen och för neurologiska komplikationer ("malingt syndrom").  Parkinsonpatienter har inte sällan autonom dysfunktion, som kan komplicera det perioperativa förloppet.  Andra sjukdomar är vanliga i denna patientgrupp.  Det är viktigt att planera det perioperativa förloppet noggrant, likaså att fortsätta med antiparkinsonmedicinering under hela det perioperativa förloppet.  Det finns idag ingen evidens för att en viss anestesimetod är att föredra framför en annan för denna patientgrupp. Regimen måste individualiseras och hänsyn tas till patientens grundmedicinering, grad av parkinsonkomplikationer och ingreppets natur.   </p

NSAID demonstrate convincing effect on postoperative pain [Elektronisk resurs]

Non-steroidal antiinflammatory drugs (NSAID) are increasingly being included in the management of postoperative pain as part of a multimodal therapeutic approach. However, there is an ongoing debate among clinicians as to the perioperative use of NSAID's as many authors have cautioned against their use in this setting. Concerns about their impact on coagulation and renal function as well as a risk for gastrointestinal bleeding have been raised. However, many of the adverse effects reported have occurred during long term treatment and might not be directly applicable to the perioperative period. Still the clinician must be aware of the potential risks and benefits of these drugs. This review focuses on the pro's and con's of perioperative NSAID usage. We address the background for a multimodal approach to postoperative pain relief as well as potential alternatives to NSAID's and the recently introduced COX2-selective inhibitors