Serotonin Concentrations in Plasma and Variations During the Menstrual Cycle

Abstract We used a specific and sensitive radioenzymatic method to establish a reference interval for the concentration of serotonin in platelet-poor plasma in 98 healthy volunteers (49 men, 49 women). The interval was 0-11 nmol/L with a median of 2.8 nmol/L. No difference in concentration in relation to sex or age was observed. In a group of eight very old volunteers (ages 86-92 years), however, concentrations were increased. In addition, we monitored the plasma concentrations of serotonin in 20 healthy women (ages 26-45 years) through two menstrual cycles. Periovulatory and premenstrual concentrations were greater than the serotonin concentration at the start of menstruation.</jats:p

Effect of Music on Vital Signs and Postoperative Pain

Pharmacological methods to improve postoperative pain are well documented, but an increasing interest in nonpharmacological methods has stimulated research in this field. Traditional and pharmacological interventions to relieve perioperative anxiety and pain are being challenged by an increasing demand for more holistic approaches. This study tested the hypothesis that listening to music preoperatively and postoperatively would affect patients\u27 experience of pain, nausea, and well-being and have an impact on their vital signs. The authors conclude that a period of peaceful rest before and after surgery reduces patient anxiety