Experimental validation of phase space conduits of transition between potential wells

A phase space boundary between transition and non-transition, similar to those observed in chemical reaction dynamics, is shown experimentally in a macroscopic system. We present a validation of the phase space flux across rank one saddles connecting adjacent potential wells and confirm the underlying phase space conduits that mediate the transition. Experimental regions of transition are found to agree with the theory to within 1\%, suggesting the robustness of phase space conduits of transition in a broad array of two or more degree of freedom experimental systems, despite the presence of small dissipation.Comment: 7 pages, 6 figure

Noise thermometry and electron thermometry of a sample-on-cantilever system below 1 Kelvin

We have used two types of thermometry to study thermal fluctuations in a microcantilever-based system below 1 K. We measured the temperature of a cantilever's macroscopic degree-of-freedom (via the Brownian motion of its lowest flexural mode) and its microscopic degrees-of-freedom (via the electron temperature of a metal sample mounted on the cantilever). We also measured both temperatures' response to a localized heat source. We find it possible to maintain thermal equilibrium between these two temperatures and a refrigerator down to at least 300 mK. These results are promising for ongoing experiments to probe quantum effects using micromechanical devices

Fast Transition between High-soft and Low-soft States in GRS 1915+105: Evidence for a Critically Viscous Accretion Flow

We present the results of a detailed analysis of RXTE observations of class $\omega$ which show an unusual state transition between high-soft and low-soft states in the microquasar GRS 1915+105. Out of about 600 pointed RXTE observations, the source was found to exhibit such state transition only on 16 occasions. An examination of the RXTE/ASM data in conjunction with the pointed observations reveals that these events appeared as a series of quasi-regular dips in two stretches of long duration (about 20 days during each occasions) when hard X-ray and radio flux were very low. The X-ray light curve and color-color diagram of the source during these observations are found to be different from any reported so far. The duration of these dips is found to be of the order of a few tens of seconds with a repetition time of a few hundred seconds. The transition between these dips and non-dips which differ in intensity by a factor of ~ 3.5, is observed to be very fast (~ a few seconds). It is observed that the low-frequency narrow QPOs are absent in the power density spectrum (PDS) of the dip and non-dip regions of class $\omega$ and the PDS is a power law in 0.1 - 10 Hz frequency range. There is a remarkable similarity in the spectral and timing properties of the source during the dip and non-dip regions in these set of observations. These properties of the source are distinctly different from those seen in the observations of other classes. This indicates that the basic accretion disk structure during both dip and non-dip regions of class $\omega$ is similar, but differ only in intensity. To explain these observations, we invoke a model in which the viscosity is very close to critical viscosity and the shock wave is weak or absent.Comment: Replaced with correct figures, Jour. of Astrophysics and Astronomy (accepted

Ultra-compact modulators based on novel CMOS-compatible plasmonic materials

We propose several planar layouts of ultra-compact plasmonic waveguide modulators that utilize alternative CMOS-compatible materials. The modulation is efficiently achieved by tuning the carrier concentration in a transparent conducting oxide layer, thereby tuning the waveguide either in plasmonic resonance or off-resonance. Resonance significantly increases the absorption coefficient of the plasmonic waveguide, which enables larger modulation depth. We show that an extinction ratio of 86 dB/um can be achieved, allowing for a 3-dB modulation depth in less than one micron at the telecommunication wavelength. Our multilayer structures can potentially be integrated with existing plasmonic and photonic waveguides as well as novel semiconductor-based hybrid photonic/electronic circuits

Rapid, multiplexed microfluidic phage display

The development of a method for high-throughput, automated proteomic screening could impact areas ranging from fundamental molecular interactions to the discovery of novel disease markers and therapeutic targets. Surface display techniques allow for efficient handling of large molecular libraries in small volumes. In particular, phage display has emerged as a powerful technology for selecting peptides and proteins with enhanced, target-specific binding affinities. Yet, the process becomes cumbersome and time-consuming when multiple targets are involved.Here we demonstrate for the first time a microfluidic chip capable of identifying high affinity phage displayed peptides for multiple targets in just a single round and without the need for bacterial infection. The chip is shown to be able to yield well-established control consensus sequences while simultaneously identifying new sequences for clinically important targets. Indeed, the confined parameters of the device allow not only for highly controlled assay conditions but also introduce a significant time-reduction to the phage display process. We anticipate that this easily-fabricated, disposable device has the potential to impact areas ranging from fundamental studies of protein, peptide, and molecular interactions, to applications such as fully automated proteomic screening

Bragg Spectroscopy of Vortex Lattices in Bose-Einstein condensates

We have measured the velocity field of a vortex lattice within a sodium Bose-Einstein condensate using Bragg scattering. The phase gradient of the macroscopic wavefunction was mapped into the spatial structure of the diffracted atom cloud, allowing for single shot measurement of the rotation parameters. A combination of spectral and spatial information yields a complete description of the superfluid flow, coarse-grained over the lattice structure, including direct and independent measurements of the rate and sense of rotation. Signatures of the microscopic quantum rotation have also been observed.Comment: 5 pages, 5 Figures, A movie built from the CM data is available in our Webpage: http://www.physics.gatech.edu/chandra/index.htm; added Fig.5 presents new data, showing signatures of the microscopic vortex structure in the diffracted clou

QCD Thermodynamics with Improved Actions

The thermodynamics of the SU(3) gauge theory has been analyzed with tree level and tadpole improved Symanzik actions. A comparison with the continuum extrapolated results for the standard Wilson action shows that improved actions lead to a drastic reduction of finite cut-off effects already on lattices with temporal extent $N_\tau=4$. Results for the pressure, the critical temperature, surface tension and latent heat are presented. First results for the thermodynamics of four-flavour QCD with an improved staggered action are also presented. They indicate similarly large improvement factors for bulk thermodynamics.Comment: Talk presented at LATTICE96(finite temperature) 4 pages, LaTeX2e file, 6 eps-file

The influence of silanisation on the mechanical and degradation behaviour of PLGA/HA composites.

This study investigates the influence of silanisation on the mechanical and degradation behaviour of PLGA/HA composites. Three different silanes (mercaptopropyl trimethoxy silane (MPTMS), aminopropyl trimethoxy silane (APTMS) and aminopropyltriethoxy silane (APTES)) were applied to HA substrates in order to study the effect of head group (which binds to the polymer) and tail group (which binds to the surface hydroxyl groups in HA). A composite of hydroxyapatite (HA) and poly(d,l lactide-co-glycolide (50:50)) (PLGA) was investigated. The influence of concentration, the reaction time, drying temperature and substrate surface on silanisation was examined. TGA was used to detect the degree of silanisation. HA with MPTMS (1wt.% MPTMS with reaction time of 1h) was used as filler in PLGA-30wt.% HA composites for an in-vitro degradation study carried out in PBS. In addition, the mechanical properties of the composites were studied. Silanisation affects the properties of the composite by improving the bonding at the interface and hence it was found to influence the plastic mechanical properties rather than the elastic mechanical properties or the degradation profile of the composite.The authors are grateful to Riverside Medical Group for the funding.This is the accepted manuscript for a paper published in Materials Science and Engineering: C Volume 48, 1 March 2015, Pages 642–650, doi: 10.1016/j.msec.2014.12.05

Poly(D,L-lactide-co-glycolide) microcomposite containing magnetic iron core nanoparticles as a drug carrier

Today many potent anticancer drugs like cisplatin are available which carry a number of side effects. A promising way of reducing the side effects is to target the drug to tissue sites by coating it with biocompatible materials like Poly (dl-lactide-co-glycolide) (PLGA) polymer where controlled drug release is achieved during the biodegradation of the polymer. Also the efficacy of anticancer drugs like cisplatin increases at elevated temperatures, so if local heating can be achieved where the drug is targeted. Local heating can be achieved by introducing iron core nanoparticles in the composites along with the drug, which can be heated by the 2.4 GHz microwaves. Local heating of the nanocomposites also helps to swell the polymer shell and enhance the drug release. The magnetic nanocomposites were synthesized using ironnanoparticles, PLGA and a fluorescent dye, tris-(2,2′bipyridyl) dichlororuthenium (II) using an oil-in-emulsion technique. The emulsion contains PLGA, dye, and ironnanoparticles dissolved in the oil phase and polyvinyl alcohol (PVA) as a stabilizer. As the sample is homogenized, and dried, uniform 100 nm composites are formed where the dye and ironnanoparticles are encapsulated in a PLGA shell. Control of the thickness and loading efficiency of the nanocomposite can be controlled by varying the ratio of PLGA, iron, and dye. The amount of loading was determined using TGA confirming from 20–50% (w/w) loading. As the dye is released from the composite the fluorescence intensity decreases due to self-quenching. This self-quenching allows for the determination of the release kinetics as a function of temperature using fluorescence spectroscopy. Initial results suggest that there is a release of 5–10% of the dye from the composite at 25°C and complete release after the nanocomposite reaches 90°C. Using local microwave heating the complete release of the dye can be accomplished with three two second pulses of 2.4 GHz microwaves. This allows for the complete drug delivery platform which allows for the controlled release using microwave frequency