Наноалмазы как идеальные наноносители для циансодежащих цитостатиков

Цианосодержащие цитостатики - новый класс открытых нами лекарств, которые благодаря цианогруппам хорошо закрепляются на наноалмазах, с увеличением активности

Влияние фосфатных связующих на физико-механические свойства периклазохромитовых огнеупоров

У данній статті наведено та порівняно фізико-механічні властивості периклазо-хромітових матеріалів в залежності від різних типів фосфатних зв’язуючих та введення різних домішок. Визначено, що найбільш раціональним є введення триполіфосфату натрію.In given clause are resulted and the physycal-mechanical properties periclase-cgromite of materials are compared depending on different of types phosphate binding and introduction of the various additives. Is determined, that most rational is the introduction treepolyphosphate sodume

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-α), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent transporters which have also recently been shown to be involved in folate transport; these include ABCB1, ABCC2 and BCRP (ABCG2). The aim of the current study was to characterise the placental mRNA and protein expression of these folate transporters throughout gestation and also to see if expression is altered in pre-eclampsia. Placental tissue was collected from women undergoing termination of pregnancy (TOP) and from women undergoing elective Caesarean section. To investigate mRNA expression quantitative real time PCR was used with gene specific oligonucleotide primers to FR-α, RFC, PCFT, ABCB1, ABCC2, BCRP and the reference gene YWHAZ. Protein expression was also characterised using immunohistochemistry of paraffin embedded placental tissue. Both protein and mRNA expression of all transporters examined decreased as the gestation progressed. Expression of FR-α and PCFT mRNA and protein were decreased in pre-eclampsia compared with normal term pregnancy. The higher levels of expression of FR-α, RFC, PCFT, ABCB1, ABCC2 and BCRP in early pregnancy indicate that these transporters may have an important role in the establishment and development of the placenta, with expression reducing in preparation for parturition. Reductions in FR-α and PCFT in pre-eclampsia may be a mechanism involved in the pathogenesis of pre-eclampsia by limiting placental folate uptake resulting in reduced levels of angiogenesis, cell proliferation and antioxidant protection

Vasodilator factors in the systemic and local adaptations to pregnancy

We postulate that an orchestrated network composed of various vasodilatory systems participates in the systemic and local hemodynamic adaptations in pregnancy. The temporal patterns of increase in the circulating and urinary levels of five vasodilator factors/systems, prostacyclin, nitric oxide, kallikrein, angiotensin-(1–7) and VEGF, in normal pregnant women and animals, as well as the changes observed in preeclamptic pregnancies support their functional role in maintaining normotension by opposing the vasoconstrictor systems. In addition, the expression of these vasodilators in the different trophoblastic subtypes in various species supports their role in the transformation of the uterine arteries. Moreover, their expression in the fetal endothelium and in the syncytiotrophoblast in humans, rats and guinea-pigs, favour their participation in maintaining the uteroplacental circulation. The findings that sustain the functional associations of the various vasodilators, and their participation by endocrine, paracrine and autocrine regulation of the systemic and local vasoactive changes of pregnancy are abundant and compelling. However, further elucidation of the role of the various players is hampered by methodological problems. Among these difficulties is the complexity of the interactions between the different factors, the likelihood that experimental alterations induced in one system may be compensated by the other players of the network, and the possibility that data obtained by manipulating single factors in vitro or in animal studies may be difficult to translate to the human. In addition, the impossibility of sampling the uteroplacental interface along normal pregnancy precludes obtaining longitudinal profiles of the various players. Nevertheless, the possibility of improving maternal blood pressure regulation, trophoblast invasion and uteroplacental flow by enhancing vasodilation (e.g. L-arginine, NO donors, VEGF transfection) deserves unravelling the intricate association of vasoactive factors and the systemic and local adaptations to pregnancy

Geoecological assessment of spatial comfort of the population and bioproductivity of landscapes (regional aspect)

The article presents a geoecological assessment of the spatial comfort of the population of the Chechen Republic, as well as the natural bioproductivity of landscapes. Cartographic and tabular materials on the problem of environmental safety have been compiled. The main ecological problem of the Republic on the reduction of productive lands per capita is indicated. Conclusions and recommendations are made on the rational use and sustainability of landscape complexes, for planning and housing of the population, and industries of farms

Intraosseous arachnoid cyst of the skull. Clinical case

The objective is to describe the clinical case of arachnoid cyst of occipital bone.Case report. Patient with arachnoid cyst of occipital bone was treated in the clinic of the A.I. Evdokimov Moscow State University of Medicine and Dentistry. The patient had severe pain in the occipital region for several years, conservative treatment was ineffective. Neuroimaging revealed an unusual intraosseous defect in the occipital bone. A partial resection of the occipital bone was performed and cranioplasty was made. During operation it was discovered that the patient had an intraosseous arachnoid cyst, the diagnosis was further confirmed by histological examination. After surgery, regression of pain in the occipital region was noted.Conclusion. The intraosseous arachnoid cyst of the skull is an extremely rare and can cause a severe local headache. Surgery is an effective treatment of this pathology.</jats:p

Geoecological assessment of spatial comfort of the population and bioproductivity of landscapes (regional aspect)

The article presents a geoecological assessment of the spatial comfort of the population of the Chechen Republic, as well as the natural bioproductivity of landscapes. Cartographic and tabular materials on the problem of environmental safety have been compiled. The main ecological problem of the Republic on the reduction of productive lands per capita is indicated. Conclusions and recommendations are made on the rational use and sustainability of landscape complexes, for planning and housing of the population, and industries of farms

Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus is a compensatory reaction under the failure of dopaminergic neurons

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