Transition in Rural Communities

This metasynthesis examines transition planning and services in rural communities, especially those in Alaska. It considers the barriers and challenges to transition implementation, the cultural responsiveness of rural educators, the developments in and suggestions for transition services, and approaches and strategies for transition planning. It illuminates the importance of building community relationships and tapping into human resources. Finally, the metasynthesis stresses the rural educator's need for cultural sensitivity in rural Alaska Native communities

The Visible Spectrum

Today, the national environmental movement is entering a new phase, led by new players, just as the still young environmental protection movement is becoming more politically influential at the local level. The political power of the environmental justice and equity movement and its links with racial and social justice organizations makes its potential impact reach far beyond “NIMBY” (not-in-my-backyard) protests. NIMBY was the first wave of quasi-organized local environmental protests, usually rooted in a single issue. Environmental justice is the next wave, drawing in a broader range of concerns. The focus of this analysis is on how environmental issues are manifesting themselves in the Greenpoint/Williamsburg area of Brooklyn. The experience of West Harlem in opposing the operation of the North River Treatment Plant is also examined. In both instances the social class and ethnic identity of these grassroots environmentalists significantly differ from those of the environmental activists of previous generations

Earthworms

Charles W. Marr, Earthworms, Kansas State University, May 1995

Aggressive Humor as a Negative Relational Maintenance Behavior during Times of Conflict

This study explores how aggressive humor is used as a negative relational maintenance behavior during conflicts in romantic relationships. Negative relational maintenance behaviors are questionable interpersonal behaviors romantic partners use to relieve personal tensions about the state of the relationship while still keeping the relationship in existence. Twenty-six participants in committed romantic relationships participated in seven semi-structured group interviews, and transcripts from these group interviews were analyzed using inductive thematic analysis. This analysis revealed participants were motivated to use aggressive humor in conflict situations to cover up topics of discussion, elicit a response from their partners, and ease tension. Aggressive humor was enacted through sarcasm, repetition, and mimicking. These findings extend existing research on negative relational maintenance behaviors and provide insight to the “dark side” of maintaining romantic relationships

The climate deception dossiers: internal fossil fuel industry memos reveal decades of corporate disinformation

This report presents seven “deception dossiers”—collections containing some 85 internal company and trade association documents that have either been leaked to the public, come to light through lawsuits, or been disclosed through Freedom of Information Act (FOIA) requests. While many of these documents have been analyzed by others (Oreskes 2011; Oreskes and Conway 2010; Gelbspan 1998), these dossiers offer the most complete and up-to-date collection yet available. Excerpts of the documents are provided in the report’s appendices; the complete dossiers—totaling some 336 pages— are available online. Each collection of internal documents reviewed here reveals a separate glimpse of a coordinated campaign underwritten by the world’s major fossil fuel companies and their allies to spread climate misinformation and block climate action. The campaign began decades ago and continues today. The fossil fuel industry—like the tobacco industry before it—is noteworthy for its use of active, intentional disinformation and deception to support its political aims and maintain its lucrative profits. The following case studies show that: Fossil fuel companies have intentionally spread climate disinformation for decades. The roots of the fossil fuel companies’ deception and disinformation run deep. Internal documents dating back to the early 1990s show a series of carefully planned campaigns of deception organized by companies and by trade groups representing the industry. As the scientific evidence concerning climate change became clear, some of the world’s largest carbon producers—including BP, Chevron, ConocoPhillips, ExxonMobil, Peabody Energy, and Shell—developed or participated in campaigns to deliberately sow confusion and block policies designed to reduce the heat-trapping emissions that cause global warming. Fossil fuel company leaders knew that their products were harmful to people and the planet but still chose to actively deceive the public and deny this harm. The letters, memos, and reports in the dossiers show that company executives have known for at least two decades that their products—coal, oil, and natural gas—cause harm to people and the climate. The campaign of deception continues today. With documents made public as recently as 2014 and 2015, the evidence is clear that a campaign of deception about global warming continues to the present. Today, most major fossil fuel companies acknowledge the main findings of climate science. Many even say they support policies to cut emissions. And yet, some of these same companies continue to support groups that spread misinformation designed to deceive the public about climate science and climate policy

RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

RUNX gene over-expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression. In contrast, chromosomal translocations involving RUNX1 are detectable in utero, suggesting an initiating role in leukemias. How do cells expressing RUNX1 fusion oncoproteins evade RUNX-mediated growth suppression? Previous studies showed that the TEL-RUNX1 fusion from t(12;21) B-ALLs is unable to induce senescence-like growth arrest (SLGA) in primary fibroblasts while potent activity is displayed by the RUNX1-ETO fusion found in t(8;21) AMLs. We now show that SLGA potential is suppressed in TEL-RUNX1 but reactivated by deletion of the TEL HLH domain or mutation of a key residue (K99R). Attenuation of SLGA activity is also a feature of RUNX1-ETO9a, a minor product of t(8;21) translocations with increased leukemogenicity. Finally, while RUNX1-ETO induces SLGA it also drives a potent senescence-associated secretory phenotype (SASP), and promotes the immortalisation of rare cells that escape SLGA. Moreover, the RUNX1-ETO SASP is not strictly linked to growth arrest as it is largely suppressed by RUNX1 and partially activated by RUNX1-ETO9a. These findings underline the heterogeneous nature of premature senescence and the multiple mechanisms by which this failsafe process is subverted in cells expressing RUNX1 oncoproteins