Detection of Parasite-Specific DNA in Urine Sediment Obtained by Filtration Differentiates between Single and Mixed Infections of \u3cem\u3eSchistosoma mansoni\u3c/em\u3e and \u3cem\u3eS. haematobium\u3c/em\u3e from Endemic Areas in Ghana

Differential diagnosis of Schistosoma mansoni and S. haematobium, which often occur sympatrically in Africa, requires both urine and stool and the procedures are low in sensitivity. The standard diagnostic tests, such as Kato-Katz (KK) for S. mansoni eggs and presence of haematuria for S. haematobium both lack sensitivity, produce false-negative results and show reduced accuracy with decreasing intensity of infection. The need for a single diagnostic test with high sensitivity and specificity for both parasites is important as many African countries are implementing Mass Drug Administration (MDA) following recommendations of the World Health Organization (WHO). Eighty-six samples of urine sediment obtained by filtration were collected from a group of 5–23 years old people from an endemic area of southern Ghana. DNA was extracted from the urine sediment on filter paper from which a species-specific repeat fragment was amplified by polymerase chain reaction (PCR) with specific primers for S. mansoni and for S. haematobium. Additionally, all participants were tested by KK (stool) and dipstick for haematuria. Diagnostic parameters for all three tests were analyzed statistically. Amplification of species-specific DNA by PCR showed much higher sensitivity (99%–100%) and specificity (100%) compared to KK and haematuria (sensitivity: 76% and 30% respectively) for both schistosome species. The same pattern was observed when the data were stratified for age group and sex specific analysis. In addition PCR amplification detected DNA from 11 individuals infected with both parasites who were negative by KK and haematuria. This approach of detecting parasite specific DNA from either or both species in a single urine specimen is a practical advantage that avoids the need for two specimens and is more effective than standard tests including those based on serology. This promises to improve the effectiveness of surveillance of MDA control programs of schistosomiasis

Lepton Numbers in the framework of Neutrino Mixing

In this short review we discuss the notion of lepton numbers. The strong evidence in favor of neutrino oscillations obtained recently in the Super-Kamiokande atmospheric neutrino experiment and in solar neutrino experiments imply that the law of conservation of family lepton numbers L_e, L_mu and L_tau is strongly violated. We consider the states of flavor neutrinos nu_e, nu_mu and nu_tau and we discuss the evolution of these states in space and time in the case of non-conservation of family lepton numbers due to the mixing of light neutrinos. We discuss and compare different flavor neutrino discovery experiments. We stress that experiments on the search for nu_mu->nu_tau and nu_e->nu_tau oscillations demonstrated that the flavor neutrino nu_tau is a new type of neutrino, different from nu_e and nu_mu. In the case of neutrino mixing, the lepton number (only one) is connected with the nature of massive neutrinos. Such conserved lepton number exist if massive neutrinos are Dirac particles. We review possibilities to check in future experiments whether the conserved lepton number exists.Comment: 20 page

The GINGER Project and status of the ring-laser of LNGS

A ring-laser attached to the Earth measures the absolute angular velocity of the Earth summed to the relativistic precessions, de Sitter and Lense-Thirring. GINGER (Gyroscopes IN GEneral Relativity) is a project aiming at measuring the LenseThirring effect with a ground based detector; it is based on an array of ring-lasers. Comparing the Earth angular velocity measured by IERS and the measurement done with the GINGER array, the Lense-Thirring effect can be evaluated. Compared to the existing space experiments, GINGER provides a local measurement, not the averaged value and it is unnecessary to model the gravitational field. It is a proposal, but it is not far from being a reality. In fact the GrossRing G of the Geodesy Observatory of Wettzell has a sensitivity very close to the necessary one. G ofWettzell is part of the IERS system which provides the measure of the Length Of the DAY (LOD); G provides information on the fast component of LOD. In the last few years, a roadmap toward GINGER has been outlined. The experiment G-GranSasso, financed by the INFN Commission II, is developing instrumentations and tests along the roadmap of GINGER. In this short paper the main activities of G-GranSasso and some results will be presented. The first results of GINGERino will be reported, GINGERino is the large ring-laser installed inside LNGS and now in the commissioning phase. Ring-lasers provide as well important informations for geophysics, in particular the rotational seismology, which is an emerging field of science. GINGERino is one of the three experiments of common interest between INFN and INGV

Pulsar motions from neutrino oscillations induced by a violation of the equivalence principle

We analize a possible explanation of the pulsar motions in terms of resonant neutrino transitions induced by a violation of the equivalence principle (VEP). Our approach, based on a parametrized post-Newtonian (PPN) expansion, shows that VEP effects give rise to highly directional contributions to the neutrino oscillation length. These terms induce anisotropies in the linear and angular momentum of the emitted neutrinos, which can account for both the observed translational and rotational pulsar motions. The violation needed to produce the actual motions is completely compatible with the existing bounds.Comment: 6 pages, no figure

Beam Tests of Ionization Chambers for the NuMI Neutrino Beam

We have conducted tests at the Fermilab Booster of ionization chambers to be used as monitors of the NuMI neutrino beamline. The chambers were exposed to proton fluxes of up to 10$^{12}$ particles/cm$^2$/1.56$\mu$s. We studied space charge effects which can reduce signal collection from the chambers at large charged particle beam intensities.Comment: submitted to IEEE Trans Nucl. Sc

The NuMI Neutrino Beam and Potential for an Off-Axis Experiment

The Neutrinos at the Main Injector (NuMI) facility at Fermilab is under construction and due to begin operations in late 2004. NuMI will deliver an intense $\nu_{\mu}$ beam of variable energy 2-20 GeV directed into the Earth at 58 mrad. Several aspects of the design are reviewed, and potential limitations to the ultimate neutrino flux are described. In addition, potential measurements of neutrino mixing properties are described.Comment: talk given at NuFact '02, Imperial College London, proceedings to appear in J. Phys. G, revised to add a referenc

Scholar-activists in an expanding European food sovereignty movement

This article analyzes the roles, relations, and positions of scholar-activists in the European food sovereignty movement. In doing so, we document, make visible and question the political dimensions of researchers' participation in the movement. We argue that scholar-activists are part of the movement, but are distinct from the affected constituencies, put in place to ensure adequate representation of key movement actors. This is because scholar-activists lack a collective identity, have no processes to formulate collective demands, and no mechanisms for inter-researcher and researchers-movement communication. We reflect on whether and how scholar-activists could organize, and discuss possible pathways for a more cohesive and stronger researcher engagement in the movement.</p