Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening.

Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions. Dibenzocyclooctyne derivatives (DIBAC and BARAC) were identified to be especially reactive dipolarophiles, which undergo the (3+2) cycloadditions with N-phenyl sydnone with the rate constant of up to 1.46 M-1 s-1. Most signifcantly, the sydnone-dibenzocyclooctyne and norbornene-tetrazine cycloadditions were predicted to be mutually orthogonal. This was validated experimentally and used for highly selective fluorescence labeling of two proteins simultaneously

Oracle NoSQL Database

Data is stored and retrieved from Database in tabular format which is called Relational Database and familiar from 1960’s as SQL (Structured Query Language) Database. Today with the rapidly increasing collected information, data driven applications are rising in science and business territories. From 21st century the term NoSQL is being popular and it is also called ‘Non SQL’ or ‘Non-Relational’ or ‘Not only SQL’. For large scale applications on datacenters or cloud distributed NoSQL systems are well known for their ease of use. There are many NoSQL non-relational Databases are introduced depending on its type based on the CAP theorem. NoSQL database data models are classified into different categories like Key- Value system, Document based system, column based system and Graph based system mainly. In this paper we will be introducing Oracle NoSQL database which is horizontally scaled with high availability, key valued database for cloud and web services. It has load balancing which is transparent even after dynamically adding new capacity

The Development of Visible‐Light Photoredox Catalysis in Flow

Visible‐light photoredox catalysis has recently emerged as a viable alternative for radical reactions otherwise carried out with tin and boron reagents. It has been recognized that by merging photoredox catalysis with flow chemistry, slow reaction times, lower yields, and safety concerns may be obviated. While flow reactors have been successfully applied to reactions carried out with UV light, only recent developments have demonstrated the same potential of flow reactors for the improvement of visible‐light‐mediated reactions. This review examines the initial and continuing development of visible‐light‐mediated photoredox flow chemistry by exemplifying the benefits of flow chemistry compared with conventional batch techniques.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106928/1/351_ftp.pd