A highly attenuating and frequency tailorable annular hole phononic crystal for surface acoustic waves

This is the final version of the article. Available from Springer Nature via the DOI in this record.Surface acoustic wave (SAW) devices are widely used for signal processing, sensing and increasingly for lab-on-a-chip applications. Phononic crystals can control the propagation of SAW, analogous to photonic crystals, enabling components such as waveguides and cavities. Here we present an approach for the realisation of robust, tailorable SAW phononic crystals, based on annular holes patterned in a SAW substrate. Using simulations and experiments, we show that this geometry supports local resonances which create highly attenuating phononic bandgaps at frequencies with negligible coupling of SAWs into other modes, even for relatively shallow features. The enormous bandgap attenuation is up to an order-of-magnitude larger than that achieved with a pillar phononic crystal of the same size, enabling effective phononic crystals to be made up of smaller numbers of elements. This work transforms the ability to exploit phononic crystals for developing novel SAW device concepts, mirroring contemporary progress in photonic crystals.The control and manipulation of propagating sound waves on a surface has applications in on-chip signal processing and sensing. Here, Ash et al. deviate from standard designs and fabricate frequency tailorable phononic crystals with an order-of-magnitude increase in attenuation.B.J.A. acknowledges funding from the EPSRC Centre for Doctoral Training in Metamaterials, grant number EP/L015331/1

Toxoplasma effectors targeting host signaling and transcription

Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions. In parallel, studies on host-pathogen interactions identified many host signaling pathways that were mysteriously altered by infection. It was only with the advent of forward and reverse genetic strategies that the connections between individual parasite effectors and the specific host pathways that they targeted finally became clear. The current repertoire of parasite effectors includes ROP kinases and pseudokinases that are secreted during invasion and that block host immune pathways. Similarly, many secretory GRA proteins alter host gene expression by activating host transcription factors, through modification of chromatin, or by inducing small noncoding RNAs. These effectors highlight novel mechanisms by whichhas learned to harness host signaling to favor intracellular survival and will guide future studies designed to uncover the additional complexity of this intricate host-pathogen interaction

Sermon Outlines; 1923

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas

Sermon Outlines; 1935

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas

Correspondence; WWI; 1913-1914

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nashhttps://digitalcommons.buffalostate.edu/nash-WWI-WWII/1001/thumbnail.jp

Sermon Outlines; 1950

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas

Speech Notes (2); 1930s-1950s

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nashhttps://digitalcommons.buffalostate.edu/nash-speeches/1002/thumbnail.jp

Sermon Outlines; 1945

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas

Michigan Street Baptist Church; Members By Street Of Residence; n.d.

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas

Sermon Outlines; 1925

These materials are a small digitized portion of the Nash Collection located in the Monroe Fordham Regional History Center, Archives & Special Collections at SUNY Buffalo State. For more information on the full collection please visit: https://library.buffalostate.edu/archives/mfc/nas