Pair correlations and random walks on integers

Abstract The paper gives conditions for a sequence of fractional parts of real numbers ( { a n x } ) n = 1 ∞ $\left( {\{ a_n x\} } \right)_{n = 1}^\infty$ to satisfy a pair correlation estimate. Here x is a fixed nonzero real number and ( a n ) n = 1 ∞ $\left( {a_n } \right)_{n = 1}^\infty$ is a random walk on the integers.</jats:p

H5N1 Clade 2.2 Polymorphism Tracing Identifies Influenza Recombination and Potential Vaccine Targets

Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 2. The genetic diversity of the serotype continues to increase. Four distinct clades or sub-clades have been linked to human cases 3.4. The gradual genetic changes identified in the sub-clades have been attributed to copy errors by viral encoded polymerases that lack an editing function, thereby resulting in antigenic drift 5. We traced polymorphism acquisition in Clade 2.2 sequences. We report here the concurrent acquisition of the same polymorphism by multiple, genetically distinct, Clade 2.2 sub-clades in Egypt, Russia and Ghana. These changes are not easily explained by the current theory of &#x201c;random mutation&#x201d; through copy error, and are more easily explained by recombination with a common source. This conclusion is supported by additional polymorphisms shared by Clade 2.2 isolates in Egypt, Nigeria and Germany including aggregation of regional polymorphisms from each of these areas into a single Nigerian human hemagglutinin gene

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

BACKGROUND: Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strategy that has been proposed involves protecting normal cells from chemotherapy by transiently inducing cell cycle arrest. Proof-of-concept for this approach, known as cyclotherapy, has been demonstrated in cell culture settings. METHODS: The eukaryotic initiation factor (eIF) 4E is a cap binding protein that stimulates ribosome recruitment to mRNA templates during the initiation phase of translation. Suppression of eIF4E is known to induce cell cycle arrest. Using a novel inducible and reversible transgenic mouse model that enables RNAi-mediated suppression of eIF4E in vivo, we assessed the consequences of temporal eIF4E suppression on CIA. RESULTS: Our results demonstrate that transient inhibition of eIF4E protects against cyclophosphamide-induced alopecia at the organismal level. At the cellular level, this protection is associated with an accumulation of cells in G1, reduced apoptotic indices, and was phenocopied using small molecule inhibitors targeting the process of translation initiation. CONCLUSIONS: Our data provide a rationale for exploring suppression of translation initiation as an approach to prevent or minimize cyclophosphamide-induced alopecia.1U01 CA168409 - NCI NIH HHS; P01 CA 87497 - NCI NIH HHS; P30 CA008748 - NCI NIH HHS; MOP-106530 - Canadian Institutes of Health Research; P01 CA013106 - NCI NIH HH

Demonstration of the Complementarity of One- and Two-Photon Interference

The visibilities of second-order (single-photon) and fourth-order (two-photon) interference have been observed in a Young's double-slit experiment using light generated by spontaneous parametric down-conversion and a photon-counting intensified CCD camera. Coherence and entanglement underlie one-and two-photon interference, respectively. As the effective source size is increased, coherence is diminished while entanglement is enhanced, so that the visibility of single-photon interference decreases while that of two-photon interference increases. This is the first experimental demonstration of the complementarity between single- and two-photon interference (coherence and entanglement) in the spatial domain.Comment: 21 pages, 7 figure

Entangled-photon Fourier optics

Entangled photons, generated by spontaneous parametric down-conversion from a second-order nonlinear crystal, present a rich potential for imaging and image-processing applications. Since this source is an example of a three-wave mixing process, there is more flexibility in the choices of illumination and detection wavelengths and in the placement of object(s) to be imaged. Moreover, this source is entangled, a fact that allows for imaging configurations and capabilities that cannot be achieved using classical sources of light. In this paper we examine a number of imaging and image-processing configurations that can be realized using this source. The formalism that we utilize facilitates the determination of the dependence of imaging resolution on the physical parameters of the optical arrangement.Comment: 41 pages, 12 figures, accepted for publication in J. Opt. Soc. Am.

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

Tetracycline or doxycycline (dox)-regulated control of genetic elements allows inducible, reversible and tissue specific regulation of gene expression in mice. This approach provides a means to investigate protein function in specific cell lineages and at defined periods of development and disease. Efficient and stable regulation of cDNAs or non-coding elements (e.g. shRNAs) downstream of the tetracycline-regulated element (TRE) requires the robust expression of a tet-transactivator protein, commonly the reverse tet-transactivator, rtTA. Most rtTA strains rely on tissue specific promoters that often do not provide sufficient rtTA levels for optimal inducible expression. Here we describe the generation of two mouse strains that enable Cre-dependent, robust expression of rtTA3, providing tissue-restricted and consistent induction of TRE-controlled transgenes. We show that these transgenic strains can be effectively combined with established mouse models of disease, including both Cre/LoxP-based approaches and non Cre-dependent disease models. The integration of these new tools with established mouse models promises the development of more flexible genetic systems to uncover the mechanisms of development and disease pathogenesis

Les grands projets hydro-agricoles en zone aride : le périmètre de Bir Amir : (gouvernorat de Tataouine, Tunisie)

Dans les régions arides et désertiques du sud de le Tunisie, l'Etat aménage des oasis - Ibn Chabat à Tozeur, Régim Mâatoug et Matrouha à Kébili... - et des périmètres irrigués - Selsoul, Ouled Yahya, El-Bassatine... à Tataouine. Ces oasis et périmètres irrigués impliquent souvent l'exploitation de ressources hydrauliques non renouvelables. Dons le gouvernorat de Tataouine, plus de 20 périmètres publics irrigués ont été aménagés ces dix dernières années. Les objectifs fixés ne sont pas toujours atteints ; les projets sont confrontés à l'abandon des parcelles, à Ia mauvaise gestion et à l'exploitation partielle. L'étude du périmètre irrigué de Bir Amir, en 1997, permet de comprendre les stratégies des exploitants (cinq types d'exploitation ont été identifiés) et de souligner les difficultés techniques, liées à la gestion de l'eau, à la nouveauté de certaines productions agricoles proposées par le projet, au manque de moyens financiers des bénéficiaires et à l'éloignement du périmètre par rapport aux villages où ils vivent