Automotive Ethernet Analyzer

Cílem této práce je navrhnout nástroj pro analýzu rozhraní 100Base-T1 (též známé jako Automotive Ethernet či BroadR-Reach). Práce je rozdělena do čtyř částí. V první části se seznámíme se standardem 100Base-T1 a čím se podobá a odlišuje od nejpoužívanějších standardů Ethernet. Následně na základě těchto znalostí navrhneme koncept jak pasivně monitorovat komunikaci na jednom síťovém segmentu tohoto rozhraní. Ve třetí části je popsána implementace potřebného hardware podle tohoto konceptu. Hardware je navržen tak, aby komunikoval s vývojovou sadou Terasic DE0-Nano-SoC. Poslední část popisuje návrh zdrojového kódu v jazyce VHDL, který dovoluje tomuto hardware fungovat a přeposílat zaznamenané pakety přes rozhraní Gigabit Ethernet, které je zabudované ve vývojové desce.The goal of this thesis is to design an analyzer tool for 100Base-T1 (also known as Automotive Ethernet or BroadR-Reach). It is split into four parts. In the first part, we acquaint ourselves with the 100Base-T1 standard and its intricacies, similarities and dissimilarities to most often used Ethernet standards. Next, based on this knowledge, we design a concept on how to passively monitor communication on a single network segment. In the third part the necessary hardware is implemented in accordance with said concept. The hardware interfaces to an FPGA development board Terasic DE0-Nano-SoC as per the assignment. The last part outlines the implementation of VHDL code that enables the hardware that was implemented to work and forward recorded packets over the development board's built-in Gigabit Ethernet interface

Adolescent mental health: Challenges with maternal noncompliance

The leading cause of suicide ideation, attempts, and completion in adolescents is persistent and unresolved parental conflict. National statistics show extremely high rates of childhood neglect and abuse are perpetrated most often by single mothers. Psychiatric disorders arising from maternal–child dysfunction are well-documented. However, resources to prevent offspring victimization are lacking. Here, we report maternal neglect of a 15-year-old male brought to the psychiatric emergency room for suicidal ideation. An inpatient treatment plan including pharmacotherapy, family therapy and psychological testing was initiated. The patient’s mother failed to attend clinic appointments or family therapy sessions. Clinician attempts to engage the mother in the treatment plan was met with verbal assaults, aggression, and threatening behavior. The patient decompensated in relation to the mother’s actions. Child Protective Services were contacted and a follow-up assessment with the patient and mother is pending. Psychiatric treatment of the mother may be a necessary intervention and prevention regimen for both the adolescent and the mother. Without consistent Child Protective Services oversight, medical and psychosocial follow-up, the prognosis and quality of life for this adolescent is considered very poor. Stringent mental health law and institutional policies are needed to adequately intercede and protect adolescents with mental illness

Evolutionary Genetics of Three Semispecies of Wood Rats--Neotoma Albigula, Neotoma Micropus, and Neotoma Floridana

Electrophoretic variation in 18 proteins encoded by 20 autosomal loci was used to compare the genetic relationships of 19 natural populations representing three species of the subgenus Neotoma. Of the 20 loci examined nine were monomorphic and fixed for the same allele in all populations. No more than seven loci were polymorphic within a single population. Genetic variability was expressed as the proportion of loci heterozygous in the average individual of a population. Heterozygosity in the three species of Neotoma studied averaged 0.078, a value within the range reported for other rodents. Although the levels of heterozygosity seen in Neotoma could not readily be explained, the variation may be attributed to ecological factors. The three species of Neotoma were compared on the basis of genetic similarity and found to form a close taxonomic unit, probably semispecies. Divergence times were obtained for the three species and found to compare well with divergence times obtained from fossil data. In general, the three species have diverged within the last 112,000 years during the Wisconsin glacial period

What do we know about behavioral crises in dementia? A systematic review

Background: Behavioral crises in dementia are represented by a wide variety of symptoms, regularly require external intervention from professionals, and are reported as a risk factor for hospital admission. Little is known about the factors that are associated with them. Aim: To determine the factors associated with dementia-related behavioral crises. Methods: We searched MEDLINE, CINAHL, PsycINFO, EMBASE and AMED databases. An additional lateral search including reference lists was conducted. Two researchers screened all records for potential eligibility. Narrative synthesis was used to bring together the findings. Results: Out of the 5544 records identified, 24 articles (18 distinct studies) met the eligibility criteria. Aggression and agitation were the most common behaviors present at crises. Delusions, wandering / absconding and hallucinations were also key behaviors contributing to crises. Behavioral crises predominantly happened in the severe stages of dementia (according to MMSE scores), in people with dementia residing in their own homes and in long-term care, and were the catalyst for admissions to psychiatric inpatient settings, specialist-care units, long-term care settings, or for referrals to psychiatric community services. Lack of consistency in assessment of behavior, and management of agitation/aggression in dementia crises were evident. Conclusion: Interventions to reduce the likelihood of people with dementia-related behaviors reaching crisis point need to focus on both family and care home settings and incorporate aggression and agitation management. Future research should focus on determining the factors that could be addressed to prevent behavioral crises and the interventions and models of care that may help to prevent crises

A case of mistaken identity: alcohol withdrawal, schizophrenia, or central pontine myelinolysis?

Demyelination is a hallmark of central pontine myelinolysis (CPM). Neuropsychiatric manifestations of this condition include weakness, quadriplegia, pseudobulbar palsy, mood changes, psychosis, and cognitive disturbances. These psychiatric symptoms are also associated with schizophrenia and alcohol withdrawal. Thus, it is clinically relevant to differentiate between CPM, schizophrenia, and alcohol withdrawal as the treatment and prognostic outcomes for each diagnosis are distinct. We present a series of events that led to a misdiagnosis of a patient admitted to the medical emergency center presenting with confusion, psychomotor agitation, and delirium who was first diagnosed with schizophrenia and alcohol withdrawal by emergency medical physicians and later discovered by the psychiatric consult team to have CPM. With a thorough psychiatric evaluation, a review of the laboratory results first showing mild hyponatremia (127 mmol/L), subsequent hypernatremia (154 mmol/L), and magnetic resonance brain imaging, psychiatrists concluded that CPM was the primary diagnosis underlying the observed neuropsychopathology. This patient has mild impairments in mood, cognition, and motor skills that remain 12 months after her emergency-center admission. This case report reminds emergency clinicians that abnormal sodium metabolism can have long-term and devastating psychopathological and neurological consequences. Differentiating between CPM, schizophrenia, and alcohol withdrawal using neuroimaging techniques and preventing the risks for CPM using slow sodium correction are paramount

PINK1 knockout rats show premotor cognitive deficits measured through a complex maze

Cognitive decline in Parkinson’s disease (PD) is a critical premotor sign that may occur in approximately 40% of PD patients up to 10 years prior to clinical recognition and diagnosis. Delineating the mechanisms and specific behavioral signs of cognitive decline associated with PD prior to motor impairment is a critical unmet need. Rodent PD models that have an impairment in a cognitive phenotype for a time period sufficiently long enough prior to motor decline can be useful to establish viable candidate mechanisms. Arguably, the methods used to evaluate cognitive decline in rodent models should emulate methods used in the assessment of humans to optimize translation. Premotor cognitive decline in human PD can potentially be examined in the genetically altered PINK1−/− rat model, which exhibits a protracted onset of motor decline in most studies. To increase translation to cognitive assessment in human PD, we used a modified non-water multiple T-maze, which assesses attention, cognitive flexibility, and working memory similarly to the Trail Making Test (TMT) in humans. Similar to the deficiencies revealed in TMT test outcomes in human PD, 4-month-old PINK1−/− rats made more errors and took longer to complete the maze, despite a hyperkinetic phenotype, compared to wild-type rats. Thus, we have identified a potential methodological tool with cross-species translation to evaluate executive functioning in an established PD rat model

Eye movements during the Iowa Gambling Task in Parkinson’s disease: a brief report

Parkinson’s disease (PD) is characterized by motor and cognitive impairments. Subtle cognitive impairment may precede motor impairment. There is a substantial need for innovative assessments, such as those involving decision-making, to detect PD in the premotor phase. Evidence suggests executive dysfunction in PD can impede strategic decision-making relying on learning and applying feedback. The Iowa Gambling Task (IGT), when combined with eye-tracking, may be a valuable synergistic strategy for predicting impaired decision-making and therapeutic non-compliance. Participants with PD and matched healthy controls completed the Movement Disorders Society’s modified Unified Parkinson’s Disease Rating Scale (UPDRS-MDS), 6-min Walk Test (6MWT), Timed Up and Go Test (TUG), Trail Making Test A and B (TMT A and B), Controlled Oral Word Association Test (COWAT), and the Barratt Impulsiveness Scale (BIS). Eye tracking was recorded during the IGT. The PD group scored significantly higher on UPDRS subscales and travelled less distance during the 6MWT despite equivalent performance on the TUG. The PD group also had longer completion times on TMT A and B and more errors on TMT B. Overall IGT winning scores were marginally worse in PD. However, when analyzed as a function of performance over time, the PD group performed significantly worse by task end, thus suggesting impaired decision-making. PD participants exhibited a 72% reduction in blinks despite equivalent outcomes in other eye-movements. Combined with established motor and executive function tests, the inclusion of eye-tracking with the IGT may represent a powerful combination of noninvasive methods to detect and monitor PD early in progression

Roles of disease severity and post-discharge outpatient visits as predictors of hospital readmissions

BACKGROUND: Risks prediction models of 30-day all-cause hospital readmissions are multi-factorial. Severity of illness (SOI) and risk of mortality (ROM) categorized by All Patient Refined Diagnosis Related Groups (APR-DRG) seem to predict hospital readmission but lack large sample validation. Effects of risk reduction interventions including providing post-discharge outpatient visits remain uncertain. We aim to determine the accuracy of using SOI and ROM to predict readmission and further investigate the role of outpatient visits in association with hospital readmission. METHODS: Hospital readmission data were reviewed retrospectively from September 2012 through June 2015. Patient demographics and clinical variables including insurance type, homeless status, substance abuse, psychiatric problems, length of stay, SOI, ROM, ICD-10 diagnoses and medications prescribed at discharge, and prescription ratio at discharge (number of medications prescribed divided by number of ICD-10 diagnoses) were analyzed using logistic regression. Relationships among SOI, type of hospital visits, time between hospital visits, and readmissions were also investigated. RESULTS: A total of 6011 readmissions occurred from 55,532 index admissions. The adjusted odds ratios of SOI and ROM predicting readmissions were 1.31 (SOI: 95 % CI 1.25–1.38) and 1.09 (ROM: 95 % CI 1.05–1.14) separately. Ninety percent (5381/6011) of patients were readmitted from the Emergency Department (ED) or Urgent Care Center (UCC). Average time interval from index discharge date to ED/UCC visit was 9 days in both the no readmission and readmission groups (p > 0.05). Similar hospital readmission rates were noted during the first 10 days from index discharge regardless of whether post-index discharge patient clinic visits occurred when time-to-event analysis was performed. CONCLUSIONS: SOI and ROM significantly predict hospital readmission risk in general. Most readmissions occurred among patients presenting for ED/UCC visits after index discharge. Simply providing early post-discharge follow-up clinic visits does not seem to prevent hospital readmissions