High precision determination of the atmospheric parameters and abundances of the COROT main targets

One of the main goals of the COROT mission is to get precise photometric observations of selected bright stars in order to allow the modelling of their interior through asteroseismology. However, in order to interpret the asteroseismological data, the effective temperature, surface gravity, and chemical composition of the stars must be known with sufficient accuracy. To carry out this task, we have developed a spectroscopic method called APASS (Atmospheric Parameters and Abundances from Synthetic Spectra) which allows precise analysis of stars with a moderate to high rotational velocity, which is the case for most primary COROT targets. Our method is based on synthetic spectra and works differentially with respect to the Sun. Using high signal-to-noise spectra and the APASS method, we determined the atmospheric parameters and chemical abundances of 13 primary COROT targets. Our results agree well with those obtained by Bruntt using his software VWA and with those obtained with the software TEMPLOGG. However, in both cases, our error bars are significantly smaller than those of other methods. Our effective temperatures are also in excellent agreement with those obtained with the IR photometry method. For five stars with relatively low rotational velocity, we also performed an analysis with a classical equivalent-width method to test agreement with APASS results. We show that equivalent-width measurements by Gaussian or Voigt profile-fitting are sensitive to the rotational broadening, leading to systematic errors whenever the projected rotation velocity is non-negligible. The APASS method appears superior in all cases and should thus be preferred.Comment: 12 pages, 6 figures, 4 tables. Accepted in A&

An asteroseismic study of the Delta Scuti star 44 Tau

In this paper we investigate theoretical pulsation models for the delta Scuti star 44 Tau. The star was monitored during several multisite campaigns which confirmed the presence of radial and nonradial oscillations. Moreover, its exceptionally low rotational velocity makes 44 Tau particulary interesting for an asteroseismic study. Due to the measured log g value of 3.6 +/- 0.1, main sequence and post-main sequence models have to be considered. We perform mode identification based on photometric and spectroscopic data. A nonadiabatic pulsation code is used to compute models that fit the identified modes. The influence of different opacity tables and element mixtures on the results is tested. The observed frequencies of 44 Tau can be fitted in both the main sequence and the post-main sequence evolutionary stage. Post-main sequence models are preferable as they fulfill almost all observational constraints (fit of observed frequencies, position in the HRD and instability range). These models can be obtained with normal chemical composition which is in agreement with recent spectroscopic measurements. The efficiency of envelope convection (in the framework of the mixing-length theory) is predicted to be very low in 44 Tau. We show that the results are sensitive to the choice between the OPAL and OP opacities. While the pulsation models of 44 Tau computed with OP opacities are considerably too cool and too faint, the use of OPAL opacities results in models within the expected temperature and luminosity range.Comment: 9 pages, 15 figures, 2 tables, accepted for publication in A&

Prospects for population synthesis in the H band: NeMo grids of stellar atmospheres compared to observations

For applications in population synthesis, libraries of theoretical stellar spectra are often considered an alternative to template libraries of observed spectra, because they allow a complete sampling of stellar parameters. Most attention in published theoretical spectral libraries has been devoted to the visual wavelength range. We present a detailed comparison of theoretical spectra in the range 1.57-1.67$\mu$m, for spectral types from A to early M and for giants and dwarf stars, with observed stellar spectra at resolutions around 3000, which would be sufficient to disentangle the different groups of late type stars. We have selected the NeMo grids of stellar atmospheres to perform such a comparison. We first demonstrate that after combining atomic and molecular line lists, it is possible to match observed spectral flux distributions with theoretical ones very well for almost the entire parameter range covered by the NeMo grids at moderate resolution in the visual range. In the infrared range, although the overall shape of the observed flux distributions is still matched reasonably well, the individual spectral features are reproduced by the theoretical spectra only for stars earlier than mid F type. For later spectral types the differences increase and theoretical spectra of K type stars have systematically weaker line features than those found in observations. These discrepancies are traced back to stem primarily from incomplete data on neutral atomic lines, although some of them are also related to molecules. Improving atomic data in the near infrared is a key element in making the construction of reliable libraries of stellar spectra in the infrared feasible.Comment: 17 pages, 19 figures, accepted for publication in A&

Development of a quality risk management method for risk assessment in continuos manufacturing process design

Die Produktion von Biopharmazeutika wie monoklonalen Antikörpern wird immer wieder vor neuen Herausforderungen wie die Erhöhung von Flexibilität und Produktivität bei gleichbleibend hoher Produktqualität und -wirksamkeit gestellt. Die etablierte Produktionsart ist die in der Regel weit verbreitete chargenmäßige Produktion, welche beim Thema Prozessanpassung notorisch zurückhaltend ist. Dennoch sind notwendige neue Technologien wie integrierte kontinuierliche Herstellungsprozesse auf dem Vormarsch, leiden aber aufgrund ihrer Komplexität aktuell unter hohen Forschungs- und Entwicklungskosten.Im Rahmen dieser Arbeit wurde eine ICH Q9 konforme qualitative Risikobewertungsmethode entwickelt, um Designentscheidungen für die Entwicklung eines integrierten kontinuierlichen Herstellungsprozesses zu unterstützen. Sie setzt sich aus Teilen verschiedener bereits etablierter Qualitätsmanagement-Tools zusammen und bringt diese in eine innovative aber spezifische Reihenfolge, wobei jeder Schritt flexibel an die verfügbaren Prozessdaten anpassbar ist. Dieser Ansatz ermöglicht die Erkennung und Bewertung von Risiken in frühen Stadien der Prozessentwicklung. Es werden abstrakte Überlegungen sichtbar gemacht und einbezogen, was in der traditionellen Prozessentwicklung nicht der Fall ist.Die Methode bietet eine ausgefeilte Möglichkeit zur Unterstützung der Prozessentwicklung, indem sie eine fundierte Grundlage für Risikominderung schafft und somit das Prozessverständnis noch vor der Prototypenfertigung verbessert, was schlussendlich die Gesamtentwicklungskosten senkt.Production of biopharmaceuticals such as monoclonal antibodies continuously meet novel challenges in the shape of higher demand for flexibility and productivity all while consistently maintaining the highest level of product quality and efficacy. Established production typically relies on the well-known but rigid batch structure, which is notoriously cautious with rash adaption. Newer technologies like integrated continuous manufacturing are emerging but suffer from high research and development expenses due to their complexity.Within this thesis, an ICH Q9 compliant qualitative risk assessment method was developed in order to support design decisions for the development of an integrated continuous manufacturing process. It is comprised of parts of various, well-established quality management tools and puts them in an innovative yet specific order, with each step still being flexible and adaptive to process available data. This approach enables risk detection and evaluation in early stages of process development, simultaneously identifying abstract considerations which are rarely included in traditional process development.The method offers a sophisticated way to support process development by providing a profound basis for risk mitigation, consequently increasing process understanding even before prototype production which reduces overall development costs.submitted by: Dominik NendwichMasterarbeit Universität für Bodenkultur Wien 2021Zusammenfassung in deutscher Sprach

Development of a quality risk management method for risk assessment in continuos manufacturing process design

Die Produktion von Biopharmazeutika wie monoklonalen Antikörpern wird immer wieder vor neuen Herausforderungen wie die Erhöhung von Flexibilität und Produktivität bei gleichbleibend hoher Produktqualität und -wirksamkeit gestellt. Die etablierte Produktionsart ist die in der Regel weit verbreitete chargenmäßige Produktion, welche beim Thema Prozessanpassung notorisch zurückhaltend ist. Dennoch sind notwendige neue Technologien wie integrierte kontinuierliche Herstellungsprozesse auf dem Vormarsch, leiden aber aufgrund ihrer Komplexität aktuell unter hohen Forschungs- und Entwicklungskosten.Im Rahmen dieser Arbeit wurde eine ICH Q9 konforme qualitative Risikobewertungsmethode entwickelt, um Designentscheidungen für die Entwicklung eines integrierten kontinuierlichen Herstellungsprozesses zu unterstützen. Sie setzt sich aus Teilen verschiedener bereits etablierter Qualitätsmanagement-Tools zusammen und bringt diese in eine innovative aber spezifische Reihenfolge, wobei jeder Schritt flexibel an die verfügbaren Prozessdaten anpassbar ist. Dieser Ansatz ermöglicht die Erkennung und Bewertung von Risiken in frühen Stadien der Prozessentwicklung. Es werden abstrakte Überlegungen sichtbar gemacht und einbezogen, was in der traditionellen Prozessentwicklung nicht der Fall ist.Die Methode bietet eine ausgefeilte Möglichkeit zur Unterstützung der Prozessentwicklung, indem sie eine fundierte Grundlage für Risikominderung schafft und somit das Prozessverständnis noch vor der Prototypenfertigung verbessert, was schlussendlich die Gesamtentwicklungskosten senkt.Production of biopharmaceuticals such as monoclonal antibodies continuously meet novel challenges in the shape of higher demand for flexibility and productivity all while consistently maintaining the highest level of product quality and efficacy. Established production typically relies on the well-known but rigid batch structure, which is notoriously cautious with rash adaption. Newer technologies like integrated continuous manufacturing are emerging but suffer from high research and development expenses due to their complexity.Within this thesis, an ICH Q9 compliant qualitative risk assessment method was developed in order to support design decisions for the development of an integrated continuous manufacturing process. It is comprised of parts of various, well-established quality management tools and puts them in an innovative yet specific order, with each step still being flexible and adaptive to process available data. This approach enables risk detection and evaluation in early stages of process development, simultaneously identifying abstract considerations which are rarely included in traditional process development.The method offers a sophisticated way to support process development by providing a profound basis for risk mitigation, consequently increasing process understanding even before prototype production which reduces overall development costs.submitted by: Dominik NendwichMasterarbeit Universität für Bodenkultur Wien 2021Zusammenfassung in deutscher Sprach

Technical requirements needed for the Wiener Linien to use dual-model vehicles

Abweichender Titel laut Übersetzung der Verfasserin/des VerfassersZsfassung in engl. SpracheDie vorliegende Diplomarbeit bietet einen Überblick über die technischen Voraus¬setzungen, die erfüllt werden müssen, um Zweisystemfahrzeuge, wie sie im Ausland bereits erfolgreich eingesetzt werden, und unter den Begriffen "Karlsruher Modell" bzw. "tram-train" bekannt sind, im Netz der Wiener Linien einsetzen zu können. Dazu werden die Unterschiede in den Systemkomponenten der in Wien bzw. dem Wiener Umland vorhandenen Eisenbahnsysteme, nämlich der Vollbahn (ÖBB), U-Bahn mit Stromschiene, U-Bahn mit Oberleitung, Wiener Lokalbahnen und Wiener Straßenbahn aufgezeigt, sowie Lösungsansätze für eine mögliche Kombination der unterschiedlichen Systeme angeführt.Vorab werden in einem eigenen Kapitel die rechtlichen Voraussetzungen behandelt, die sich aufgrund der unterschiedlichen Klassifikation der auftretenden Eisenbahn¬systeme in der vorhandenen Rechtssystematik ergeben.Der Hauptteil der Arbeit befasst sich mit den technischen Grundlagen, die in mehreren Unterabschnitten beschrieben werden. Eine wesentliche Komponente stellt der Fahrweg bzw. das Rad-Schiene-System dar. Weitere Kapitel beschäftigen sich mit dem Streckennetz bzw. den Trassierungs¬parametern und der Gestaltung der Fahrzeuge. Das Kapitel Bahnsteige behandelt die Unterschiede der vorhandenen Bahnsteigsysteme und mögliche Maßnahmen, um auch bei einem systemüber¬greifenden Fahrzeugeinsatz barrierefreie Einstiegsverhältnisse für die Fahrgäste anbieten zu können. Danach werden die Systemkomponenten Antrieb - Traktion und abschließend die Unterschiede und Kobinationsmöglichkeiten der Sicherungssysteme erläutert.Zuletzt werden die erforderlichen Voraussetzungen anhand eines Anwendungs¬beispiels, der möglichen Verknüpfung der Straßenbahnlinie 60 mit der Kaltenleut¬gebner Bahn, zusammengefasst.This master's thesis gives an overview concerning the technical requirements needed for the Wiener Linien to use dual-model vehicles, which have successfuly been introduced abroad and are known under the term "Karlsruher Modell" or "tram-train". The differences between the components of the railway systems which exist in and around Vienna, that is: railway (ÖBB), underground with contact rail, underground with overhead contact line, "Wiener Lokalbahnen" and tramway are listed, and basic approaches for possible combinations of the different systems are suggested.The legal requirements based on the different classifications of the existing railway systems in the present legal system are dealt with in an introducing chapter .The main part of this thesis deals with the technical requirements which have been described in various chapters.An essential section concerns the track-components and the wheel-rail-system.Other chapters consider the rail networks with their layout parameters and the configuration of the vehicles.The chapter "platforms" deals with the differences between the existing platform layouts and possible measures to allow barriere-free train entrances for passengers. Thereafter, the component traction will be dealt with and the difference and possible combination of signalling and fail-safe systems will be explained.In conclusion, a summary of the necessary requirements will be illustrated to explain the connection between the tramway route 60 and the Kaltenleutgebner railway.15