The influence of a single defect in composite gate insulators on the performance of nanotube transistors

The current through a carbon nanotube field-effect transistor (CNFET) with cylindrical gate electrode is calculated using the nonequilibrium Greens function method in a tight-binding approximation. The obtained result is in good agreement with the experimental data. The space radiation and nuclear radiation are known to cause defects in solids. The theoretical approach is used to calculate the amplitude of the random-telegraph-signal (RTS) noise due to a single defect in the gate oxide of a long channel p-type CNFET. We investigate how the amplitude of the RTS noise is affected by the composite structure of gate insulators, which contains an inner insulator with a dielectric constant larger than 3.9 and an outer insulator with a dielectric constant of 3.9 (as for SiO2). It is found that the RTS amplitude increases apparently with the decreasing thickness of the inner gate insulator. If the inner insulator is too thin, even though its dielectric constant is as large as 80, the amplitude of the RTS noise caused by the charge of Q = +1e may amount to around 80% in the turn-on region. Due to strong effects of defects in CNFETs, CNFETs have a potential to be used for detecting the space radiation or nuclear radiation.Comment: 8 Figure

GW170817/GRB 170817A/AT2017gfo association: some implications for physics and astrophysics

On 17 August 2017, a gravitational wave event (GW170817) and an associated short gamma-ray burst (GRB 170817A) from a binary neutron star merger had been detected. The followup optical/infrared observations also identified the macronova/kilonova emission (AT2017gfo). In this work we discuss some implications of the remarkable GW170817/GRB 170817A/AT2017gfo association. We show that the $\sim 1.7$s time delay between the gravitational wave (GW) and GRB signals imposes very tight constraint on the superluminal movement of gravitational waves (i.e., the relative departure of GW velocity from the speed of light is $\leq 4.3\times 10^{-16}$) or the possible violation of weak equivalence principle (i.e., the difference of the gamma-ray and GW trajectories in the gravitational field of the galaxy and the local universe should be within a factor of $\sim 3.4\times 10^{-9}$). The so-called Dark Matter Emulators and a class of contender models for cosmic acceleration ("Covariant Galileon") are ruled out, too. The successful identification of Lanthanide elements in the macronova/kilonova spectrum also excludes the possibility that the progenitors of GRB 170817A are a binary strange star system. The high neutron star merger rate (inferred from both the local sGRB data and the gravitational wave data) together with the significant ejected mass strongly suggest that such mergers are the prime sites of heavy r-process nucleosynthesis.Comment: 8 pages, 3 figures, Accepted for Publication in ApJ

Precipitation controls on nutrient budgets in subtropical and tropical forests and the implications under changing climate

Biological, geological and hydrological drivers collectively control forest biogeochemical cycling. However, based on a close examination of recent literature, we argue that the role of hydrological control particularly precipitation on nutrient budgets is significantly underestimated in subtropical and tropical forests, hindering our predictions of future forest nutrient status under a changing climate in these systems. To test this hypothesis, we analyzed two decades of monthly nutrient input and output data in precipitation and streamwater from a subtropical forested watershed in Taiwan, one of the few sites that has long-term nutrient input-output data in the tropics and subtropics. The results showed that monthly input and output of all ions and budgets (output – input) of most ions were positively correlated with precipitation quantity and there was a surprisingly greater net ion export during the wet growing season, indicating strong precipitation control on the nutrient budget. The strong precipitation control is also supported by the divergence of acidic precipitation and near neutral acidity of streamwater, with the former being independent from precipitation quantity but the latter being positively related to precipitation quantity. An additional synthesis of annual precipitation quantity and nutrient budgets of 32 forests across the globe showed a strong correlation between precipitation quantity and nutrient output-input budget, indicating that strong precipitation control is ubiquitous at the global scale and is particularly important in the humid tropical and subtropical forests. Our results imply that climate change could directly affect ecosystem nutrient cycling in the tropics through changes in precipitation pattern and amount

Nonlinear energy-loss straggling of protons and antiprotons in an electron gas

The electronic energy-loss straggling of protons and antiprotons moving at arbitrary nonrelativistic velocities in a homogeneous electron gas are evaluated within a quadratic response theory and the random-phase approximation (RPA). These results show that at low and intermediate velocities quadratic corrections reduce significantly the energy-loss straggling of antiprotons, these corrections being, at low-velocities, more important than in the evaluation of the stopping power.Comment: 4 pages, 3 figures, to appear in Phys. Rev.

Kerker-Type Positional Disorder Immune Metasurfaces

Metasurfaces that can work without the rigorous periodic arrangement of meta-atoms are highly desired by practical optical micro-nano devices. In this work, we proposed two kinds of Kerker-type metasurfaces possessing positional disorder immunity. The metasurfaces are composed of two different core-shell cylinders satisfying the first and second Kerker conditions, respectively. Even with large positional disorder perturbation of the meta-atoms, the metasurfaces can still maintain the same excellent performances as periodic ones, such as the total transmission and magnetic mirror responses. This disorder immunity is due to the unidirectional forward and backward scatterings of a single core-shell cylinder leading to very weak lateral couplings between neighboring cylinders thus rarely affecting the multiple scatterings in the forward or backward direction. In contrast, the dominant response of the disordered non-Kerker-type metasurface decreases significantly. Our findings provide a new idea for designing robust metasurfaces and extend the scope of metasurface applications in sensing and communication under complex practical circumstances.Comment: 18 pages, 9 figure

Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis

X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D retinal organoid in vitro differentiation system. This model recapitulates key features of XLRS including retinal splitting, defective retinoschisin production, outer-segment defects, abnormal paxillin turnover, and impaired ER-Golgi transportation. RS1 mutation also affects the development of photoreceptor sensory cilia and results in altered expression of other retinopathy-associated genes. CRISPR/Cas9 correction of the disease-associated C625T mutation normalizes the splitting phenotype, outer-segment defects, paxillin dynamics, ciliary marker expression, and transcriptome profiles. Likewise, mutating RS1 in control hiPSCs produces the disease-associated phenotypes. Finally, we show that the C625T mutation can be repaired precisely and efficiently using a base-editing approach. Taken together, our data establish 3D organoids as a valid disease model

PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells

<p>Abstract</p> <p>Background</p> <p>Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, however, its function in inhibiting telomerase activity of tumor cells is not well documented. Here we show that PinX1 is essential for down-regulation telomerase activity of nasopharyngeal carcinoma.</p> <p>Methods</p> <p>Expression vectors of human PinX1 (pEGFP-C3-PinX1) and its small interfering RNA (PinX1-FAM-siRNA) were constructed and transfected into NPC. Their effects on mRNA of telomerase catalytic subunit (hTERT), telomerase activity, cell proliferation, cell migration, wound healing, cell cycles and apoptosis were examined using semi-quantitative RT-PCR, stretch PCR, MTT assay, Transwell, scratch assay and flow cytometry, respectively.</p> <p>Results</p> <p>Transfection of pEGFP-C3-PinX1 and PinX1-FAM-siRNA increased and reduced PinX1 mRNA by 1.6-fold and 70%, respectively. Over-expression of PinX1 decreased hTERT mRNA by 21%, reduced telomerase activity, inhibited cell growth, migration and wound healing ability, arrested cells in G0/G1 phase, and increased apoptotic index. In contrast, down-regulation of PinX1 did not alter the above characteristics.</p> <p>Conclusions</p> <p>PinX1 may play important roles in NPC proliferation, migration and apoptosis and has application potential in tumor-targeted gene therapy.</p

Origin, Transport, and Vertical Distribution of Atmospheric Polluntants over the Northern Sourth China Sea During the 7-SEAS-Dongsha Experiment

During the spring of 2010, comprehensive in situ measurements were made for the first time on a small atoll (Dongsha Island) in the northern South China Sea (SCS), a key region of the 7-SEAS (the Seven South East Asian Studies) program. This paper focuses on characterizing the source origins, transport processes, and vertical distributions of the Asian continental outflows over the region, using measurements including mass concentration, optical properties, hygroscopicity, and vertical distribution of the aerosol particles, as well as the trace gas composition. Cluster analysis of backward trajectories classified 52% of the air masses arriving at ground level of Dongsha Island as having a continental origin, mainly from northern China to the northern SCS, passing the coastal area and being confined in the marine boundary layer (0-0.5 km). Compared to aerosols of oceanic origin, the fine mode continental aerosols have a higher concentration, extinction coefficient, and single-scattering albedo at 550 nm (i.e., 19 vs. 14 microg per cubic meter in PM(sub 2.5); 77 vs. 59 M per meter in beta(sub e); and 0.94 vs. 0.90 in omega, respectively). These aerosols have a higher hygroscopicity (f at 85% RH = 2.1) than those in the upwind inland regions, suggesting that the aerosols transported to the northern SCS were modified by the marine environment. In addition to the near-surface aerosol transport, a significant upper-layer (3-4 km) transport of biomass-burning aerosols was observed. Our results suggest that emissions from both China and Southeast Asia could have a significant impact on the aerosol loading and other aerosol properties over the SCS. Furthermore, the complex vertical distribution of aerosols-coinciding-with-clouds has implications for remote-sensing observations and aerosol-cloud-radiation interactions