Closing the gap: human factors in cross-device media synchronization

The continuing growth in the mobile phone arena, particularly in terms of device capabilities and ownership is having a transformational impact on media consumption. It is now possible to consider orchestrated multi-stream experiences delivered across many devices, rather than the playback of content from a single device. However, there are significant challenges in realising such a vision, particularly around the management of synchronicity between associated media streams. This is compounded by the heterogeneous nature of user devices, the networks upon which they operate, and the perceptions of users. This paper describes IMSync, an open inter-stream synchronisation framework that is QoE-aware. IMSync adopts efficient monitoring and control mechanisms, alongside a QoE perception model that has been derived from a series of subjective user experiments. Based on an observation of lag, IMSync is able to use this model of impact to determine an appropriate strategy to catch-up with playback whilst minimising the potential detrimental impacts on a users QoE. The impact model adopts a balanced approach: trading off the potential impact on QoE of initiating a re-synchronisation process compared with retaining the current levels of non-synchronicity, in order to maintain high levels of QoE. A series of experiments demonstrate the potential of the framework as a basis for enabling new, immersive media experiences

Baguette:towards end-to-end service orchestration in heterogeneous networks

Network services are the key mechanism for operators to introduce intelligence and generate profit from their infrastructures. The growth of the number of network users and the stricter application network requirements have highlighted a number of challenges in orchestrating services using existing production management and configuration protocols and mechanisms. Recent networking paradigms like Software Defined Networking (SDN) and Network Function Virtualization (NFV), provide a set of novel control and management interfaces that enable unprecedented automation, flexibility and openness capabilities in operator infrastructure management. This paper presents Baguette, a novel and open service orchestration framework for operators. Baguette supports a wide range of network technologies, namely optical and wired Ethernet technologies, and allows service providers to automate the deployment and dynamic re-optimization of network services. We present the design of the orchestrator and elaborate on the integration of Baguette with existing low-level network and cloud management frameworks

The BlueTides simulation: first galaxies and reionization

We introduce the BlueTides simulation and report initial results for the luminosity functions of the first galaxies and AGN, and their contribution to reionization. BlueTides was run on the BlueWaters cluster at NCSA from $z=99$ to $z=8.0$ and includes 2$\times$7040$^3$ particles in a $400$Mpc/h per side box, making it the largest hydrodynamic simulation ever performed at high redshift. BlueTides includes a pressure-entropy formulation of smoothed particle hydrodynamics, gas cooling, star formation (including molecular hydrogen), black hole growth and models for stellar and AGN feedback processes. The star formation rate density in the simulation is a good match to current observational data at $z\sim 8-10$. We find good agreement between observations and the predicted galaxy luminosity function in the currently observable range $-18\le M_{\mathrm UV} \le -22.5$ with some dust extinction required to match the abundance of brighter objects. BlueTides implements a patchy reionization model that produces a fluctuating UV background. BlueTides predicts number counts for galaxies fainter than current observational limits which are consistent with extrapolating the faint end slope of the luminosity function with a power law index $\alpha\sim -1.8$ at $z\sim 8$ and redshift dependence of $\alpha\sim (1+z)^{-0.4}$. The AGN population has a luminosity function well fit by a power law with a slope $\alpha\sim -2.4$ that compares favourably with the deepest CANDELS-Goods fields. We investigate how these luminosity functions affect the progress of reionization, and find that a high Lyman-$\alpha$ escape fraction ($f_\mathrm{esc} \sim 0.5$) is required if galaxies dominate the ionising photon budget during reionization. Smaller galaxy escape fractions imply a large contribution from faint AGN (down to $M_\mathrm{UV}=-12$) which results in a rapid reionization, disfavoured by current observations

The formation of milky way-mass disk galaxies in the first 500 million years of a cold dark matter universe

Whether or not among the myriad tiny protogalaxies there exists a population with similarities to present-day galaxies is an open question. We show, using BlueTides, the first hydrodynamic simulation large enough to resolve the relevant scales, that the first massive galaxies to form are predicted to have extensive rotationally supported disks. Although their morphology resembles in some ways Milky Way types seen at much lower redshifts, these high-redshift galaxies are smaller, denser, and richer in gas than their low-redshift counterparts. From a kinematic analysis of a statistical sample of 216 galaxies at redshift z = 8–10, we have found that disk galaxies make up 70% of the population of galaxies with stellar mass ${10}^{10}{M}_{\odot }$ or greater. Cold dark matter cosmology therefore makes specific predictions for the population of large galaxies 500 million years after the Big Bang. We argue that wide-field satellite telescopes (e.g., WFIRST) will in the near future discover these first massive disk galaxies. The simplicity of their structure and formation history should make new tests of cosmology possible

A Case Fore Buffer Zones

Golf tournaments are fun and exciting events because they allow for up-close interaction with players, but they also present a risk management concern. Professional golfers are not immune to hitting errant golf shots and a lack of buffer zones often results in spectator injury. The purpose of this paper is to examine how buffer zones can be enhanced or developed to protect patrons. Utilizing data from the PGA Tour, a model was developed to aid in predicting errant tee shots to enhance buffer zones

The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm

The precocious germination of cereal grains before harvest, also known as pre-harvest sprouting, is an important source of yield and quality loss in cereal production. Pre-harvest sprouting is a complex grain defect and is becoming an increasing challenge due to changing climate patterns. Resistance to sprouting is multi-genic, although a significant proportion of the sprouting variation in modern wheat cultivars is controlled by a few major quantitative trait loci, including Phs-A1 in chromosome arm 4AL. Despite its importance, little is known about the physiological basis and the gene(s) underlying this important locus. In this study, we characterized Phs-A1 and show that it confers resistance to sprouting damage by affecting the rate of dormancy loss during dry seed after-ripening. We show Phs-A1 to be effective even when seeds develop at low temperature (13 °C). Comparative analysis of syntenic Phs-A1 intervals in wheat and Brachypodium uncovered ten orthologous genes, including the Plasma Membrane 19 genes (PM19-A1 and PM19-A2) previously proposed as the main candidates for this locus. However, high-resolution fine-mapping in two bi-parental UK mapping populations delimited Phs-A1 to an interval 0.3 cM distal to the PM19 genes. This study suggests the possibility that more than one causal gene underlies this major pre-harvest sprouting locus. The information and resources reported in this study will help test this hypothesis across a wider set of germplasm and will be of importance for breeding more sprouting resilient wheat varieties

Sources of Funding and Factors Influencing Choice of Journal

Open access (OA) journals distribute their content at no charge and use other means of funding the publication process. Publication fees or article processing charges (APC)s have become the predominant means for funding professional OA publishing. We surveyed 1,038 authors who recently published articles in 74 OA journals that charge APCs stratified into seven discipline categories. Authors were asked about the source of funding for the APC, factors influencing their choice of a journal and past history publishing in OA and subscription journals. Additional information about the journal and the authors’ country were obtained from the journal website. A total of 429 (41%) authors from 69 journals completed the survey. There were large differences in the source of funding among disciplines. Journals with impact factors charged higher APCs as did journals from disciplines where grant funding is plentiful. Fit, quality, and speed of publication where the most important factors in the authors’ choice of a journal. Open access was less important but a significant factor for many authors in their choice of a journal to publish. These findings are consistent with other research on OA publishing and suggest OA publishing funded through APCs is likely to continue to grow.nonPeerReviewe

MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: Post Genome-Wide Association Analysis in the BEACON Consortium.

Incidence of esophageal adenocarcinoma (EA) has increased substantially in recent decades. Multiple risk factors have been identified for EA and its precursor, Barrett's esophagus (BE), such as reflux, European ancestry, male sex, obesity, and tobacco smoking, and several germline genetic variants were recently associated with disease risk. Using data from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) genome-wide association study (GWAS) of 2,515 EA cases, 3,295 BE cases, and 3,207 controls, we examined single nucleotide polymorphisms (SNPs) that potentially affect the biogenesis or biological activity of microRNAs (miRNAs), small non-coding RNAs implicated in post-transcriptional gene regulation, and deregulated in many cancers, including EA. Polymorphisms in three classes of genes were examined for association with risk of EA or BE: miRNA biogenesis genes (157 SNPs, 21 genes); miRNA gene loci (234 SNPs, 210 genes); and miRNA-targeted mRNAs (177 SNPs, 158 genes). Nominal associations (P0.50), and we did not find evidence for interactions between variants analyzed and two risk factors for EA/BE (smoking and obesity). This analysis provides the most extensive assessment to date of miRNA-related SNPs in relation to risk of EA and BE. While common genetic variants within components of the miRNA biogenesis core pathway appear unlikely to modulate susceptibility to EA or BE, further studies may be warranted to examine potential associations between unassessed variants in miRNA genes and targets with disease risk.This work was supported by the National Institutes of Health [R01CA136725 to T.L.V. and D.C.W, T32CA009168 to T.L.V, and K05CA124911 to T.L.V.]. Additional funding sources for individual studies included in the BEACON GWAS, and for BEACON investigators, have been acknowledged previously (16).This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pone.012861

Cholangiocarcinoma: Validation of Surgical Selection and Prognostic Methodologies

Background: Cholangiocarcinoma is a rare cancer with a poor prognosis. Radical surgical resection is the only option for curative treatment. Optimal determination of resectability is required so that patients can be stratified into operative or chemotherapeutic treatment cohorts. This thesis sought to validate and augment contemporaneous resectability systems in a large independent European validation cohort. Numerous putative prognostic histo-pathological and demographic characteristics have been reported to effect Overall Survival (OS). This thesis sought to validate a variety of histopathological, clinical and radiological systems and to determine the clinical prognostic utility of these systems. Improved prognostication through biomarkers has been suggested, and direct analysis of tumour may allow the development of a more personalised therapeutic approach. This thesis sought to define the utility of 2 potential prognostic biomarkers, hENT1 and Ki67, via direct immunohistochemical analysis of resected and biopsied patient specimens. Methods: Standardised meta-analytical methods were utilised to stratify clinical and biomarker prognostic co-variates. These clinical and biomarker co-variates were then assessed and validated within the context of a large, noncontinuous, European, contemporaneous registry of surgically resected cholangiocarcinoma patients at Aintree University Hospital between June 2006 – February 2017. Forty-four resected patient’s specimens and 58 non-matched biopsy specimens were acquired from CellNass. Two Tissue Matched Array’s (TMA’s) were constructed and immunohistochemical assessment of hENT1 and Ki67 abundance was undertaken. Results: Regression analyses identified that BC score, MSKCC score, age at diagnosis and left artery involvement were all significant independent predictor’s of resectability. The meta-analysis highlighted the significance of clinical prognostic variables affecting OS. The significant prognostic factors which had an effect upon OS were; ‘T’ status, lymph node involvement, microvascular invasion, peri-neural invasion, tumour differentiation and age. Numerous pre and post-operative co-variates retained prognostic utility when assessed within the validation cohort. Meta-analytical methods demonstrated that Ki67 and hENT1 biomarkers had significant prognostic effects for immunohistochemically assessed patients. Immunohistochemical assessment of the TMA specimens was undertaken. hENT1 and Ki67 abundance did not demonstrate significant survival correlates. However, an alternative commercially available hENT1 antibody was determined to demonstrate selectivity and utility in accurately assessing hENT1 abundance in resected peri-hilar cholangiocarcinoma specimens. 17 Conclusion: This thesis externally validated the utility of standardised scoring systems for pre-operatively stratifying patients for potential resection. It has also provided a potential novel anatomical co-variate which could be used to augment scoring systems to increase predictive accuracy. This thesis validated standardised clinical prognostic systems and provided novel and augmented alternative systems which explained variability in OS in the validation cohort. This thesis has validated an alternative commercially available hENT1 antibody which can accurately determine hENT1 abundance in resected peri-hilar cholangiocarcinoma specimens