Estimating Density and Residency of Bottlenose Dolphins (Tursiops truncatus) in three estuarine sites in South Carolina

Of the three estuarine bottlenose dolphin stocks in South Carolina, two are considered data insufficient, with no minimum population estimate or assigned potential biological removal value. Additionally, the Northern Georgia Southern South Carolina Estuarine System (NGSSCES) stock’s boundaries are based on sighting data that do not extend to the full area encompassed by the boundary lines. In areas where stock boundaries are not clearly defined and data is insufficient for traditional methods of estimating abundance, density may provide insight into local distributions and serve as a proxy for actual abundance. Photo-identification surveys were conducted in three sites, representative of the two data insufficient estuarine stocks, between March 2012 and February 2013. Linear density (dolphins/km transect) was similar for all three sites (p=0.0773) and resident dolphins made up between 15.45% and 23.61% of total individuals within each site. Additionally, there was no movement of individuals between study areas, specifically between the two sites that make up the NGSSCES stock. These patterns provide evidence that estuarine bottlenose dolphins in South Carolina share similar characteristics regardless of stock designation, and that the NGSSCES stock might be comprised of smaller, independent communities or sub-populations. Current management approaches for estuarine bottlenose dolphin stocks in South Carolina are problematic due to the uncertainty of stock boundaries and abundance. If future studies continue to identify small groups of dolphins with strong site fidelity or small home ranges such as in this study, the traditional stock concept might need to be re-evaluated with management efforts shifting toward simple measures of linear density to determine relative abundance

Photovoltaic Tracker Optimization with Unique Fault Detection and Enhanced Combiner System

Renewable energy resources are rapidly becoming extremely important as the world\u27s energy consumption continues to rise. The most popular of these resources is solar energy and more specifically photovoltaic energy. Currently, solar modules on the market are still not highly efficient. In order to increase the productivity of solar energy systems, larger fixed-panel photovoltaic systems or tracking photovoltaic systems are utilized. The major disadvantage of larger photovoltaic systems is the increased space requirements. Therefore, tracking photovoltaic systems are the best alternative to achieve higher solar energy yields. To date, the only method of monitoring tracking photovoltaic systems is with the aid of existing inverters. However, inverters account for approximately 50% of photovoltaic system faults making this technique highly unreliable. This method is also very broad in the level of monitoring, limiting the data to the combined power of all photovoltaic strings wired to the inverter. Therefore, small-scale faults within the system will go unnoticed and significantly reduce energy yield over time. This thesis research proposes a solution to the poor fault detection monitoring systems available for photovoltaic tracker applications. The improved monitoring system developed is capable of monitoring tracking photovoltaic systems down to the individual string current level. The system is controlled with a Programmable Logic Controller and monitors a maximum of sixteen photovoltaic strings. The system is also able to monitor the combined string voltage of the sixteen strings to aid in accurate power calculations. The unique feature of the developed monitoring system is the integration of the combiner system. This further utilizes the existing components of the systems and will greatly increase photovoltaic tracker productivity for many years to come

Sea level rise guidance for nearshore habitat restoration in Puget Sound

Many agencies, organizations, and communities across Puget Sound are working to restore nearshore habitats from historic degradation to reestablish or maintain the functionality of these ecosystems. Sea level rise is expected to cause increased coastal flooding in low-lying areas and increased storm surge reach in coastal zones. There is widespread recognition that these new threats must be addressed in the siting, design, and maintenance of Puget Sound’s nearshore habitat restoration projects, especially given the limited resources available for restoration. In spite of this, existing information on sea level rise has not yet been synthesized in a way that facilitates incorporation into nearshore restoration. Building off the Washington Coastal Resilience Project (WCRP), the study team has developed a draft guidance document that will help restoration practitioners and funders identify the specific issues that sea level rise raises for restoration. This guidance document is being developed using results from a Restoration and Sea Level Rise Workshop held in the spring on 2017, which brought together some of Puget Sound’s best restoration experts to help identify how restoration decisions may be affected by sea level rise, and to identify specific restoration questions or issues that sea level rise raises for restoration efforts. By breaking the question down into a set of shoreforms and specific restoration actions, the guidance aims to provide practitioners with the tools needed to plan restoration in a way that is robust to sea level rise and more likely to ensure a resilient path to recovery

Advancing science and policy through a coordinated international study of physical activity and built environments: IPEN Adult methods

Background: National and international strategies to increase physical activity emphasize environmental and policy changes that can have widespread and long-lasting impact. Evidence from multiple countries using comparable methods is required to strengthen the evidence base for such initiatives. Because some environment and policy changes could have generalizable effects and others may depend on each country’s context, only international studies using comparable methods can identify the relevant differences. Methods: Currently 12 countries are participating in the International Physical Activity and the Environment Network (IPEN) study. The IPEN Adult study design involves recruiting adult participants from neighborhoods with wide variations in environmental walkability attributes and socioeconomic status (SES). Results: Eleven of twelve countries are providing accelerometer data and 11 are providing GIS data. Current projections indicate that 14,119 participants will provide survey data on built environments and physical activity and 7145 are likely to provide objective data on both the independent and dependent variables. Though studies are highly comparable, some adaptations are required based on the local context. Conclusions: This study was designed to inform evidence-based international and country-specific physical activity policies and interventions to help prevent obesity and other chronic diseases that are high in developed countries and growing rapidly in developing countries

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2) : a randomised controlled trial and process evaluation

Background Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage fluid have been validated as effective markers for exclusion of ventilator-associated pneumonia. The VAPrapid2 trial aimed to determine whether measurement of bronchoalveolar lavage fluid IL-1β and IL-8 could effectively and safely improve antibiotic stewardship in patients with clinically suspected ventilator-associated pneumonia. Methods VAPrapid2 was a multicentre, randomised controlled trial in patients admitted to 24 ICUs from 17 National Health Service hospital trusts across England, Scotland, and Northern Ireland. Patients were screened for eligibility and included if they were 18 years or older, intubated and mechanically ventilated for at least 48 h, and had suspected ventilator-associated pneumonia. Patients were randomly assigned (1:1) to biomarker-guided recommendation on antibiotics (intervention group) or routine use of antibiotics (control group) using a web-based randomisation service hosted by Newcastle Clinical Trials Unit. Patients were randomised using randomly permuted blocks of size four and six and stratified by site, with allocation concealment. Clinicians were masked to patient assignment for an initial period until biomarker results were reported. Bronchoalveolar lavage was done in all patients, with concentrations of IL-1β and IL-8 rapidly determined in bronchoalveolar lavage fluid from patients randomised to the biomarker-based antibiotic recommendation group. If concentrations were below a previously validated cutoff, clinicians were advised that ventilator-associated pneumonia was unlikely and to consider discontinuing antibiotics. Patients in the routine use of antibiotics group received antibiotics according to usual practice at sites. Microbiology was done on bronchoalveolar lavage fluid from all patients and ventilator-associated pneumonia was confirmed by at least 104 colony forming units per mL of bronchoalveolar lavage fluid. The primary outcome was the distribution of antibiotic-free days in the 7 days following bronchoalveolar lavage. Data were analysed on an intention-to-treat basis, with an additional per-protocol analysis that excluded patients randomly assigned to the intervention group who defaulted to routine use of antibiotics because of failure to return an adequate biomarker result. An embedded process evaluation assessed factors influencing trial adoption, recruitment, and decision making. This study is registered with ISRCTN, ISRCTN65937227, and ClinicalTrials.gov, NCT01972425. Findings Between Nov 6, 2013, and Sept 13, 2016, 360 patients were screened for inclusion in the study. 146 patients were ineligible, leaving 214 who were recruited to the study. Four patients were excluded before randomisation, meaning that 210 patients were randomly assigned to biomarker-guided recommendation on antibiotics (n=104) or routine use of antibiotics (n=106). One patient in the biomarker-guided recommendation group was withdrawn by the clinical team before bronchoscopy and so was excluded from the intention-to-treat analysis. We found no significant difference in the primary outcome of the distribution of antibiotic-free days in the 7 days following bronchoalveolar lavage in the intention-to-treat analysis (p=0·58). Bronchoalveolar lavage was associated with a small and transient increase in oxygen requirements. Established prescribing practices, reluctance for bronchoalveolar lavage, and dependence on a chain of trial-related procedures emerged as factors that impaired trial processes

Measurements of the pp → ZZ production cross section and the Z → 4ℓ branching fraction, and constraints on anomalous triple gauge couplings at √s = 13 TeV

Four-lepton production in proton-proton collisions, pp -> (Z/gamma*)(Z/gamma*) -> 4l, where l = e or mu, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The ZZ production cross section, sigma(pp -> ZZ) = 17.2 +/- 0.5 (stat) +/- 0.7 (syst) +/- 0.4 (theo) +/- 0.4 (lumi) pb, measured using events with two opposite-sign, same-flavor lepton pairs produced in the mass region 60 4l) = 4.83(-0.22)(+0.23) (stat)(-0.29)(+0.32) (syst) +/- 0.08 (theo) +/- 0.12(lumi) x 10(-6) for events with a four-lepton invariant mass in the range 80 4GeV for all opposite-sign, same-flavor lepton pairs. The results agree with standard model predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ. couplings at 95% confidence level: -0.0012 < f(4)(Z) < 0.0010, -0.0010 < f(5)(Z) < 0.0013, -0.0012 < f(4)(gamma) < 0.0013, -0.0012 < f(5)(gamma) < 0.0013