Graduates of Character - Values and Character: Higher Education and Graduate Employment

Graduates of Character is the product of an empirical enquiry into the values, virtues, dispositions and attitudes of a sample of students and employees who volunteered to be involved. The research team sought host sites which would offer a diverse set of interviewees in gender, ethnicity, religion and aspiration. In this study we discuss what character is taken to mean by students and employees in their years of higher education and employment. We examine what their values are, what they gain from the university, what they believe employers look for when recruiting, what they hope to give to an employer, and what they expect from their employer. We then explore who or what influenced their values and moral development. We also examined the role of the personal tutor or mentor, and the persons or services to which they might go for personal and/or professional support

International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients

OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a theoretical advantage of delaying the onset of androgen-independent prostate cancer, (AIPC) that are associated with success, highlighting features which require exploration with prospective trials to establish the best strategies for using this treatment. METHODS: Individual data were collated on 1446 patients with adequate information, from 10 phase II studies with >50 cases, identified through Pubmed. RESULTS: Univariate and multivariate Cox proportional hazard models were developed to predict treatment success with a high degree of statistical success. The prostate-specific antigen (PSA) nadir, the PSA threshold to restart treatment, and medication type and duration, were important predictors of outcome. CONCLUSIONS: The duration of biochemical remission after a period of HT is a durable early indicator of how rapidly AIPC and death will occur, and will make a useful endpoint in future trials to investigate the best ways to use IHT based on the important treatment cycling variables described above. Patients spent a mean of 39% of the time off treatment. The initial PSA level and PSA nadir allow the identification of patients with prostate cancer in whom it might be possible to avoid radical therapy.Peer reviewe

A matrix isolation and computational study of molecular palladium fluorides : does PdF₆ exist?

Palladium atoms generated by thermal evaporation and laser ablation were reacted with and trapped in F₂ /Ar, F₂ /Ne, and neat F₂ matrices. The products were characterized by electronic absorption and infrared spectroscopy, together with relativistic density functional theory calculations as well as coupled cluster calculations. Vibrational modes at 540 and 617 cm⁻¹ in argon matrices were assigned to molecular PdF and PdF₂ , and a band at 692 cm⁻¹ was assigned to molecular PdF₄ . A band at 624 cm⁻¹ can be assigned to either PdF₃ or PdF₆, with the former preferred from experimental considerations. Although calculations might support the latter assignment, our conclusion is that in these detailed experiments there is no convincing evidence for PdF₆

Using Semantic Web Technologies to Support Enhanced Situation Awareness

The AKTiveSA project is using Semantic Web technologies to support information fusion and enhanced situational awareness in a simulated humanitarian relief scenario. We have developed an application that shows how situational awareness can be supported during humanitarian relief situations; often occurring alongside military conflict. Semantic Web technologies provide new opportunities for harvesting information from numerous, disparate and often heterogeneous information sources and can be used to better support complex knowledge fusion

Automatic Data for Applied Railway Management

In 2009, London Overground management implemented a new tactical plan for a.m. and p.m. peak service on the North London Line (NLL). This paper documents that tactical planning intervention and evaluates its outcomes in terms of certain aspects of service delivery (the operator's perspective on system performance) and service quality (the passenger's perspective). Analyses of service delivery and quality and of passenger demand contributed to the development, proposal, and implementation of the new tactical plan. NLL trains were delayed routinely en route, with excessive dwell time a major cause. Near-random passenger incidence behavior suggested that an even headway service for NLL might have been more appropriate. The confluence of these analyses was confirmed by the corresponding excess journey time results. On the basis of longitudinal analysis, an evaluation showed that on-time performance increased substantially and observed journey time decreased with the introduction of the new plan. Overall, the effects of this implementation appeared to have been positive on balance. This case study thus demonstrated the applicability of automatic data generally, and certain measures and techniques in the London Overground specifically, to support the tactical planning of an urban railway.Transport for London (Organization

Low temperature/short duration steaming as a sustainable method of soil disinfection

This report was presented at the UK Organic Research 2002 Conference. Soil samples containing resting structures of fungal crop pathogens (Verticillium dahliae, Sclerotinia sclerotiorum, Sclerotium cepivorum, Pythium ultimum), potato cyst nematodes (Globodera rostochiensis and Globodera pallida) and weeds (Chenopodium album and Agropyron repens) were treated with aerated steam in the laboratory at temperatures ranging from 50–80oC in a specially constructed apparatus. Steaming at 50 or 60oC for three minutes, followed by an eight-minute resting period in the steamed soil and immediate removal from the soil thereafter, resulted in 100% kill of all weeds, fungi and nematodes. Low temperature/ short duration soil steaming could become a sustainable alternative to chemical or high-temperature steam soil disinfestation

Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity

In humans, neural tube closure defects occur in 1: 1000 pregnancies. The design of new strategies for the prevention of such common defects would benefit from an improved understanding of the molecular events underlying neurulation. Neural fold elevation is a key morphological process that acts during neurulation to drive neural tube closure. However, to date, the molecular pathways underpinning neural fold elevation have not been elucidated. Here, we use morpholino knock-down technology to demonstrate that Repulsive Guidance Molecule (RGMa)-Neogenin interactions are essential for effective neural fold elevation during Xenopus neurulation and that loss of these molecules results in disrupted neural tube closure. We demonstrate that Neogenin and RGMa are required for establishing the morphology of deep layer cells in the neural plate throughout neurulation. We also show that loss of Neogenin severely disrupts the microtubule network within the deep layer cells suggesting that Neogenin-dependent microtubule organization within the deep cells is essential for radial intercalation with the overlying superficial cell layer, thereby driving neural fold elevation. In addition, we show that sustained Neogenin activity is also necessary for the establishment of the apicobasally polarized pseudostratified neuroepithelium of the neural tube. Therefore, our study identifies a novel signaling pathway essential for radial intercalation and epithelialization during neural fold elevation and neural tube morphogenesis. Copyright ©2008 Society for Neuroscienc

Shuttle Planning for Link Closures in Urban Public Transport Networks

Urban public transport systems must periodically close certain links for maintenance, which can have significant effects on the service provided to passengers. In practice, the effects of closures are mitigated by replacing the closed links with a simple shuttle service. However, alternative shuttle services could reduce inconvenience at a lower operating cost. This paper proposes a model to select shuttle lines and frequencies under budget constraints. We propose a new formulation that allows a minimal frequency restriction on any line that is operated and minimizes passenger inconvenience cost, which includes transfers and frequency-dependent waiting time costs. This model is applied to a shuttle design problem based on a real-world case study of the Massachusetts Bay Transportation Authority network of Boston, Massachusetts. The results show that additional shuttle routes can reduce passenger delay compared to the standard industry practice, while also distributing delay more equally over passengers, at the same operating budget. The results are robust under different assumptions about passenger route choice behavior. Computational experiments show that the proposed formulation, coupled with a preprocessing step, can be solved faster than prior formulations

Selection, Stability and Renormalization

We illustrate how to extend the concept of structural stability through applying it to the front propagation speed selection problem. This consideration leads us to a renormalization group study of the problem. The study illustrates two very general conclusions: (1) singular perturbations in applied mathematics are best understood as renormalized perturbation methods, and (2) amplitude equations are renormalization group equations.Comment: 38 pages, LaTeX, two PostScript figures available by anonymous ftp to gijoe.mrl.uiuc.edu (128.174.119.153) files /pub/front_kkfest_fig