The Challenges of the "Software Support for Industrial Controls" Contract

ST division is currently specifying a 'Software Support for Industrial Controls' contract. The application of this contract and its success will require several changes in our habits for specifying, designing, and maintaining control systems. This paper summarizes some key concepts which should be respected in order to obtain maximum benefits from the future contract and to optimize the software activities in the division. The contract concerns the maintenance and development of the monitoring and control systems used for supervising CERN's technical infrastructure (electrical distribution, cooling water, air conditioning, safety, and access control). The systems concerned consist of computer and communication hardware and software, tailored to provide specific functionalities for the remote operation, command, and monitoring of equipment. All these systems use commercially available software and hardware such as SCADA, PLCs and associated drivers, controllers, fieldbuses, and networks. It is intended to contract out these activities on a results-oriented basis

Software Support for Industrial Controls Contract

The contract covers the development and the operation and maintenance (O&M) of the monitoring and control systems used for supervising CERN's technical infrastructure. The contract involves those responsible for equipment in any current or future technical installation. We are outsourcing a complex activity which will require efforts on both preparing the specifications for new projects and setting clear definitions of tasks and procedures for O&M. It is a result-oriented contract in which performance will be continually evaluated by different methods and tools: project management plan and project follow-up, and CAMMS (Computerised Assets and Maintenance Management system). To be used effectively, this approach requires complete traceability of activities and documentation of the systems. Based on the analysis of the results measured and the shared (CERN and contractor) experience, the O&M activities will be reviewed and reorganised and operational procedures will be changed according to needs. A key issue of this contract is the challenge of establishing a good partnership with the contractor in order to reach the goals

Summary of ST-MA deliverables for LHC

The ST/MA group is responsible for the monitoring of the CERN Technical Infrastructure as well as the design, installation and maintenance of personnel protection system such as access control system, fire and gas leak detection, safety alarm monitoring systems and radiation monitoring systems (in collaboration with TIS). This paper provides an overview of the main projects and services managed in the group and outlines the scope, the organisation and the planning of the main deliverables for LHC

A Common Software Configuration Management System for CERN SPS and LEP Accelerators and Technical Services

Software configuration management activities are crucial to assure the integrity of current operational and the quality of new software either being developed at CERN or outsourced. The functionality of the present management system became insufficient with large maintenance overheads. In order to improve our situation, a new software configuration management system has been set up. It is based on Razor, a commercial tool, which supports the management of file versions and operational software releases, along with integrated problem reporting capabilities. In addition to the basic tool functionality, automated procedures were custom made, for the installation and distribution of operational software. Policies were developed and applied over the software development life cycle to provide visibility and control. The system ensures that, at all times, the status and location of all deliverable versions are known, the state of shared objects is carefully controlled and unauthorised changes prevented. It provides a managed environment for software development, in various domains of the SPS and LEP CERN accelerators, and the technical services, automating code and lifecycle management. This paper outlines the reasons for selecting the chosen tool, the implementation of the system, the problems solved and the final goals achieved

Affine arithmetic-based methodology for energy hub operation-scheduling in the presence of data uncertainty

In this study, the role of self-validated computing for solving the energy hub-scheduling problem in the presence of multiple and heterogeneous sources of data uncertainties is explored and a new solution paradigm based on affine arithmetic is conceptualised. The benefits deriving from the application of this methodology are analysed in details, and several numerical results are presented and discussed

LHC Communication Infrastructure: Recommendations from the working group

The LHC Working Group for Communication Infrastructure (CIWG) was established in May 1999 with members from the accelerator sector, the LHC physics experiments, the general communication services, the technical services and other LHC working groups. It has spent a year collecting user requirements and at the same time explored and evaluated possible solutions appropriate to the LHC. A number of technical recommendations were agreed, and areas where more work is required were identified. The working group also put forward proposals for organizational changes needed to allow the design project to continue and to prepare for the installation and commissioning phase of the LHC communication infrastructure. This paper reports on the work done and explains the motivation behind the recommendations

Invasive pulmonary aspergillosis 10 years post bone marrow transplantation: a case report

Abstract Introduction Invasive pulmonary aspergillosis is a leading cause of mortality and morbidity in bone marrow transplant recipients. Establishing the diagnosis remains a challenge for clinicians working in acute care setting. However, prompt diagnosis and treatment can lead to favourable outcomes Case presentation We report a case of invasive aspergillosis occurring in a 39-year-old Caucasian female 10 years after an allogeneic haematopoietic bone marrow transplant, and 5 years after stopping all immunosuppression. Possible risk factors include bronchiolitis obliterans and exposure to building dust (for example, handling her husband's dusty overalls). There are no similar case reports in the literature at this time. Conclusion High clinical suspicion, especially in the setting of failure to respond to broad-spectrum antibiotics, should alert clinicians to the possibility of invasive pulmonary aspergillosis, which, in this case, responded to antifungal therapy.</p

HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production

BACKGROUND: Direct cellular contact with stimulated T cells is a potent mechanism that induces cytokine production in human monocytes in the absence of an infectious agent. This mechanism is likely to be relevant to T cell-mediated inflammatory diseases such as rheumatoid arthritis and multiple sclerosis. Microparticles (MP) generated by stimulated T cells (MPT) display similar monocyte activating ability to whole T cells, isolated T cell membranes, or solubilized T cell membranes. We previously demonstrated that high-density lipoproteins (HDL) inhibited T cell contact- and MPT-induced production of IL-1beta but not of its natural inhibitor, the secreted form of IL-1 receptor antagonist (sIL-1Ra). METHODOLOGY/PRINCIPAL FINDINGS: Labeled MPT were used to assess their interaction with monocytes and T lymphocytes by flow cytometry. Similarly, interactions of labeled HDL with monocytes and MPT were assessed by flow cytometry. In parallel, the MPT-induction of IL-1beta and sIL-1Ra production in human monocytes and the effect of HDL were assessed in cell cultures. The results show that MPT, but not MP generated by activated endothelial cells, bond monocytes to trigger cytokine production. MPT did not bind T cells. The inhibition of IL-1beta production by HDL correlated with the inhibition of MPT binding to monocytes. HDL interacted with MPT rather than with monocytes suggesting that they bound the activating factor(s) of T cell surface. Furthermore, prototypical pro-inflammatory cytokines and chemokines such as TNF, IL-6, IL-8, CCL3 and CCL4 displayed a pattern of production induced by MPT and inhibition by HDL similar to IL-1beta, whereas the production of CCL2, like that of sIL-1Ra, was not inhibited by HDL. CONCLUSIONS/SIGNIFICANCE: HDL inhibit both MPT binding to monocytes and the MPT-induced production of some but not all cytokines, shedding new light on the mechanism by which HDL display their anti-inflammatory functions