Dermatologische Proktologie: Eine Übersicht anhand des Pruritus ani

Zusammenfassung: Pruritus ani ist eines der häufigsten Symptome, die den Patienten in die proktologische Sprechstunde führen. Als Ursache können zahlreiche Krankheiten zugrunde liegen. Bei einem Großteil aller Patienten mit Pruritus ani finden sich dermatologische Ursachen. Fast jede Dermatose kann sich auch perianal manifestieren und zu Pruritus führen. Eine Blickdiagnose ist selten möglich, da die klinische Präsentation häufig atypisch ist. So sind für die Diagnosestellung neben ausführlicher Anamnese und körperlicher Untersuchung mit Ganzkörperhautstatus mikrobiologische und allergologische Abklärungen sowie eine Hautbiopsie wichtige diagnostische Maßnahmen. Begleitend zur Behandlung der Grundkrankheit empfiehlt sich als Basistherapie eine milde Reinigung mit seifenfreiem Wasser, anschließendem vorsichtigen Trocknen sowie die Anwendung von rückfettenden oder zinkhaltigen Extern

Evaluation of the Welfare of the Lesson Horse used for Equine Assisted Activities and Therapies

The welfare of horses used in Equine Assisted Activities and Therapies (EAAT) has long been debated due to a lack of agreement in interpreting horse behavior, specifically in response to stress factors. This study was constructed to analyze changes in heart rate to determine if horses experienced identifiable stress responses when used in an EAAT lesson program. Eight healthy, regularly working therapeutic riding horses were randomly selected and monitored on two testing days. Both “stressful” and “relaxed” behavioral observations were recorded during lessons for each subject. Neither stress responses nor relaxed responses were affected by the number of lessons (P > 0.30) or the age of horses (P > 0.38) when horses participated in two lessons in a given day. Horses managed with proper care and well-being practices are well suited to participate in at least two EAAT lessons daily, as minimal stress responses were observed.M.S

Exhibit caution: incorporating alternate reality technology into museums

Over the past few decades, public history institutions have faced many different challenges. Some of these challenges stem from the rise in technology. Previously, if someone wanted to learn more about a subject, a trip to a museum could provide valuable information through heavily researched exhibits. However, as the Internet became easily accessible, all this information was readily available with a simple search. Museums were no longer necessary to find answers to the burning questions of history. To combat this idea, many museums began to take steps to keep their visitor numbers up by incorporating emerging technology into their exhibits; technology that was not readily available to the general public. Historians needed to create narratives and exhibitions that could be boosted by modern technology. With this idea in mind, museums expanded into the fast-growing media of augmented reality (AR) and virtual reality (VR). This expansion has led to some great successes and strides in the field of exhibition design, but some roadblocks remain, especially for smaller institutions. To incorporate augmented and virtual reality, museums must consider cost, exhibit caution, and use the technology in a way that works well as an additional piece to an exhibition. Once all these factors have been taken into account, augmented and virtual reality can be an amazing tool for museums. With such a focus on the lengths that AR/VR technology can go, my research hopes to shine a light on some of its greatest accomplishments so far while also bringing to light some concerns and potential downfalls of its incorporation. In the appendix, I have included my capstone project for my Digital Media minor, in which I created a pamphlet on the positives and negatives of incorporating augmented and virtual reality into a museum.Thesis (B.?)Honors Colleg

Sweet Dreams

Ebony pencil and white gel pen; 8" x 10

CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo

Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of CARD14 gain-of-function mutations remains to be fully determined in vivo. Here, we report that heterozygous mice harboring a CARD14 gain-of-function mutation (Card14ΔE138) spontaneously develop a chronic psoriatic phenotype with characteristic scaling skin lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and immune cell infiltration. Affected skin of these mice is characterized by elevated expression of anti-microbial peptides, chemokines and cytokines (including Th17 cell-signature cytokines), and an immune infiltrate rich in neutrophils, myeloid cells and T-cells, reminiscent of human psoriatic skin. Disease pathogenesis was driven by the IL-23/IL-17 axis and neutralization of IL-23p19, the key cytokine in maintaining Th17 cell polarization, significantly reduced skin lesions and the expression of antimicrobial peptides and pro-inflammatory cytokines. Therefore, hyperactivation of CARD14 alone is sufficient to orchestrate the complex immunopathogenesis that drives Th17-mediated psoriasis skin disease in vivo

Homology and persistent homology

Treballs Finals de Grau de Matemàtiques, Facultat de Matemàtiques, Universitat de Barcelona, Any: 2020, Director: Francisco Belchí Guillamón[en] Extracting information from data sets that are high-dimensional, incomplete and noisy is generally challenging. The aim of this work is to explain a homology theory for data sets, called Persistent Homology, and the topology and algebra behind it. Moreover, we will show different ways to represent it and finally computing some examples with the help of the GUDHI software for Python

Electoral System Choice in Transition Countries. The Importance of Driving Forces

This research paper examines the relationship between the type of transition and electoral system choice.The analysis is based upon a country sample of 51 third-wave democracies. The theoretical argumentslead to the hypothesis that countries whose transitions to democracy are driven both by the ruling elitesand civic forces apply more permissive electoral systems afterwards. Whenever there is one dominantactor during the transition process, a less permissive electoral system becomes more likely. It is alsoassumed that countries that have a democratic past tend to rely on the institutional design of that period.The results of a multiple regression analysis confirm the hypotheses and point out that political actorsbehave strategically and according to their utility function, especially in transition processes, which arecharacterized by great uncertainty. Ideology does not matter and information from the past is used topredict future developments

Vergleich technischer Implementierungen für GridFlow-Systeme

With the compact warehousing of goods, the main aim is to achieve the highest possible space utilisation rate. Automated compact warehouses only become profitable once they exceed a particular size and throughput. The alternative is to opt for low-cost ground storage systems. This book will examine various technical implementation methods that can be used to realise the GridFlow principle