Towards the Modeling of Neuronal Firing by Gaussian Processes

This paper focuses on the outline of some computational methods for the approximate solution of the integral equations for the neuronal firing probability density and an algorithm for the generation of sample-paths in order to construct histograms estimating the firing densities. Our results originate from the study of non-Markov stationary Gaussian neuronal models with the aim to determine the neuron's firing probability density function. A parallel algorithm has been implemented in order to simulate large numbers of sample paths of Gaussian processes characterized by damped oscillatory covariances in the presence of time dependent boundaries. The analysis based on the simulation procedure provides an alternative research tool when closed-form results or analytic evaluation of the neuronal firing densities are not available.Comment: 10 pages, 3 figures, to be published in Scientiae Mathematicae Japonica

Performance Comparison in the "Follicular Neoplasm" Category Between the American, British, Italian, and Japanese Systems for Reporting Thyroid Cytopathology

It is now almost ten years that the United Stated of America, England, Italy and Japan had their own reporting system to classify thyroid lesions. Important confusion and uncertainties dominated the "follicular-patterned lesions", a category also known as the "gray zone". Every cytopathologist was using a personal terminology to describe and call lesions made up of a variable admixture of macro- and microfollicular structures. These personal views varied considerably between cytopathologists and generated a great deal of confusion among patients (the cytological report being almost incomprehensible to them), clinicians and even within the same cytopathology community. With the advent of national reporting systems, things changed in a better way and standardized reporting systems became the standard of practice in thyroid cytology. The outcome of the widespread use of standardized diagnostic categories was the reduction of descriptive diagnoses and the improved communication between pathologists, clinicians and patients. In this article we review the major reporting systems, analyze their similarities and differences in the "indeterminate" or "follicular-patterned" diagnostic categories, and when possible, try to assess their performance

The Cochlear Tuning Curve

The tuning curve of the cochlea measures how large an input is required to elicit a given output level as a function of the frequency. It is a fundamental object of auditory theory, for it summarizes how to infer what a sound was on the basis of the cochlear output. A simple model is presented showing that only two elements are sufficient for establishing the cochlear tuning curve: a broadly tuned traveling wave, moving unidirectionally from high to low frequencies, and a set of mechanosensors poised at the threshold of an oscillatory (Hopf) instability. These two components suffice to generate the various frequency-response regimes which are needed for a cochlear tuning curve with a high slope

Numerical predictions of the turbulent cavitating flow around a marine propeller and an axial turbine

The numerical predictions of cavitating flow around a marine propeller working in non-uniform inflow and an axial turbine are presented. The cavitating flow is modelled using the homogeneous (mixture) model. Time-dependent simulations are performed for the marine propeller case using OpenFOAM. Three calibrated mass transfer models are alternatively used to model the mass transfer rate due to cavitation and the two-equation SST (Shear Stress Transport) turbulence model is employed to close the system of the governing equations. The predictions of the cavitating flow in an axial turbine are carried out with ANSYS-CFX, where only the native mass transfer model with tuned parameters is used. Steady-state simulations are performed in combination with the SST turbulence model, while time-dependent results are obtained with the more advanced SAS (Scale Adaptive Simulation) SST model. The numerical results agree well with the available experimental measurements, and the simulations performed with the three different calibrated mass transfer models are close to each other for the propeller flow. Regarding the axial turbine the effect of the cavitation on the machine efficiency is well reproduced only by the time dependent simulations

A lattice study of the strangeness content of the nucleon

We determine the quark contributions to the nucleon spin Delta s, Delta u and Delta d as well as their contributions to the nucleon mass, the sigma-terms. This is done by computing both, the quark line connected and disconnected contributions to the respective matrix elements, using the non-perturbatively improved Sheikholeslami-Wohlert Wilson Fermionic action. We simulate n_F=2 mass degenerate sea quarks with a pion mass of about 285 MeV and a lattice spacing a = 0.073 fm. The renormalization of the matrix elements involves mixing between contributions from different quark flavours. The pion-nucleon sigma-term is extrapolated to physical quark masses exploiting the sea quark mass dependence of the nucleon mass. We obtain the renormalized value sigma_{piN}=38(12) MeV at the physical point and the strangeness fraction f_{Ts}=sigma_s/m_N=0.012(14)(+10-3) at our larger than physical sea quark mass. For the strangeness contribution to the nucleon spin we obtain in the MSbar scheme at the renormalization scale of 2.71 GeV Delta s = -0.020(10)(2).Comment: 7 pages, 3 figures, Invited Talk at the 33rd Erice School on Nuclear Physics, Erice, 16-24 September 2011, Ital

IDIOPATHIC PARTIAL EPILEPSY WITH AUDITORY FEATURES (IPEAF): A CLINICAL AND GENETIC STUDY OF 53 SPORADIC CASES

The purpose of our study was to describe the clinical characteristics of sporadic (S) cases of partial epilepsy with auditory features (PEAF) and pinpoint clinical, prognostic and genetic differences with respect to previously reported familial (F) cases of autosomal dominant partial epilepsy with auditory features (ADPEAF). We analysed 53 patients (24 females and 29 males) with PEAF diagnosed according to the following criteria: partial epilepsy with auditory symptoms, negative family history for epilepsy and absence of cerebral lesions on NMR study. All patients underwent a full clinical, neuroradiological and neurophysiological examination. Forty patients were screened for mutations in LGI1/epitempin, which is involved in ADPEAF. Age at onset ranged from 6 to 39 years (average 19 years). Secondarily generalized seizures were the most common type of seizures at onset (79%). Auditory auras occurred either in isolation (53%) or associated with visual, psychic or aphasic symptoms. Low seizure frequency at onset and good drug responsiveness were common, with 51% of patients seizure-free. Seizures tended to recur after drug withdrawal. Clinically, no major differences were found between S and F patients with respect to age at onset, seizure frequency and response to therapy. Analysis of LGI1/epitempin exons failed to disclose mutations. Our data support the existence of a peculiar form of non-lesional temporal lobe epilepsy closely related to ADPEAF but without a positive family history. This syndrome, here named IPEAF, has a benign course in the majority of patients and could be diagnosed by the presence of auditory aura. Although LGI1 mutations have been excluded, genetic factors may play an aetiopathogenetic role in at least some of these S cases

Numerical Prediction of Cavitating Vortex Rope in a Draft Tube of a Francis Turbine with Standard and Calibrated Cavitation Model

Transient simulations of flow in a Francis turbine were performed with a goal to predict pressure pulsation frequencies and amplitudes caused by rotating vortex rope at part load operating regime. Simulations were done with the SAS SST turbulence model with curvature correction on basic and refined computational meshes. Without cavitation modelling too small values of frequency and amplitudes were obtained. With mesh refinement the calculated amplitudes were a bit closer to the measured values, while the accuracy of predicted frequency did not improve at all. Agreement between measured and numerical values was significantly improved when cavitation was included in simulations. In addition, the predicted value of the dominant frequency was slightly more accurate when, in the Zwart et al. cavitation model, the default condensation and evaporation model constants were replaced with previously calibrated ones