Hypofractionated stereotactic radiotherapy for acoustic neuromas: safety and effectiveness over 8 years of experience.

Little information is available about long-term outcomes of hypofractionated stereotactic radiotherapy (hypo-FSRT) for acoustic neuromas. In this study, the safety and effectiveness of hypo-FSRT for unilateral acoustic neuroma were reviewed over 8 years of experience at our institution

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

Hepatic lipogenesis is nutritionally regulated (i.e. downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription factor SREBP-1c are known to be critical for nutritionally regulated lipogenesis upstream mechanisms governing Srebf1 expression remain unclear. Here we show that the fasting-induced transcription factor KLF15 a key regulator of gluconeogenesis forms a complex with LXR/RXR specifically on the Srebf1 promoter. This complex recruits the corepressor RIP140 instead of the coactivator SRC1 resulting in reduced Srebf1 and thus downstream lipogenic enzyme expression during the early and euglycemic period of fasting prior to hypoglycemia and PKA activation. Through this mechanism KLF15 overexpression specifically ameliorates hypertriglyceridemia without affecting LXR-mediated cholesterol metabolism. These findings reveal a key molecular link between glucose and lipid metabolism and have therapeutic implications for the treatment of hyperlipidemia.journal articl

動的結合で高分子量化した結晶性高分子の新規機能

University of Tokyo (東京大学