Effect of dehydration, produced by mercupurin, on the plasma volume of normal persons

1. 1. Plasma volume, serum protein concentration, hematocrit value, arterial and venous blood pressures, and body weight were determined in ten normal subjects before, and twenty-four hours after, the injection of 2 c.c. of mercupurin.2. 2. There was a fall in plasma volume in every case, averaging 544 +/- 87.7 c.c., or 15.7 +/- 2.4 per cent of the control determination; an average rise in serum proteins of 0.74 +/- 0.14 Gm., or 11.5 +/- 2.6 per cent; and an average rise in hematocrit of 2.9 +/- 0.6, or 6.9 +/- 1.8 per cent.3. 3. A diuresis was experienced in every case; the mean was 1.73 +/- 0.3 kg., or 2.6 +/- 0.5 per cent of the body weight.4. 4. Associated with the diuresis and decrease in plasma volume, there was a fall in venous pressure and pulse pressure.5. 5. In some instances, the subjects exhibited weakness, apathy, dizziness, and faintness, suggesting a diminution in cardiac output.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32575/1/0000704.pd

NaCl exchange and renal amyloid

Based on the fact that in healthy people a dry diet with large amounts of NaCl is the strongest diuretia, the author decided to test the effect of such a diet in amyloid patients.</jats:p