Unhealthy yet Avoidable-How Cognitive Bias Modification Alters Behavioral and Brain Responses to Food Cues in Individuals with Obesity

Obesity is associated with automatically approaching problematic stimuli, such as unhealthy food. Cognitive bias modification (CBM) could beneficially impact problematic approach behavior. However, it is unclear which mechanisms are targeted by CBM in obesity. Candidate mechanisms include: (1) altering reward value of food stimuli; and (2) strengthening inhibitory abilities. Thirty-three obese adults completed either CBM or sham training during functional magnetic resonance imaging (fMRI) scanning. CBM consisted of implicit training to approach healthy and avoid unhealthy foods. At baseline, approach tendencies towards food were present in all participants. Avoiding vs. approaching food was associated with higher activity in the right angular gyrus (rAG). CBM resulted in a diminished approach bias towards unhealthy food, decreased activation in the rAG, and increased activation in the anterior cingulate cortex. Relatedly, functional connectivity between the rAG and right superior frontal gyrus increased. Analysis of brain connectivity during rest revealed training-related connectivity changes of the inferior frontal gyrus and bilateral middle frontal gyri. Taken together, CBM strengthens avoidance tendencies when faced with unhealthy foods and alters activity in brain regions underpinning behavioral inhibition.Peer reviewe

Hemispheric asymmetries in resting-state EEG and fMRI are related to approach and avoidance behaviour, but not to eating behaviour or BMI

Much of our behaviour is driven by two motivational dimensions-approach and avoidance. These have been related to frontal hemispheric asymmetries in clinical and resting-state EEG studies: Approach was linked to higher activity of the left relative to the right hemisphere, while avoidance was related to the opposite pattern. Increased approach behaviour, specifically towards unhealthy foods, is also observed in obesity and has been linked to asymmetry in the framework of the right-brain hypothesis of obesity. Here, we aimed to replicate previous EEG findings of hemispheric asymmetries for self-reported approach/avoidance behaviour and to relate them to eating behaviour. Further, we assessed whether resting fMRI hemispheric asymmetries can be detected and whether they are related to approach/avoidance, eating behaviour and BMI. We analysed three samples: Sample 1 (n = 117) containing EEG and fMRI data from lean participants, and Samples 2 (n = 89) and 3 (n = 152) containing fMRI data from lean, overweight and obese participants. In Sample 1, approach behaviour in women was related to EEG, but not to fMRI hemispheric asymmetries. In Sample 2, approach/avoidance behaviours were related to fMRI hemispheric asymmetries. Finally, hemispheric asymmetries were not related to either BMI or eating behaviour in any of the samples. Our study partly replicates previous EEG findings regarding hemispheric asymmetries and indicates that this relationship could also be captured using fMRI. Our findings suggest that eating behaviour and obesity are likely to be mediated by mechanisms not directly relating to frontal asymmetries in neuronal activation quantified with EEG and fMRI.Peer reviewe

Pennsylvania Folklife Vol. 36, No. 4

• The Art of Glass Blowing • Portrait Painting • The Ox Roast • Herbal Soap-Making • Fly-Fishing and Fly-Tying • Chalkware • Silversmithing • Festival Focus • Festival Programs • Coopering • Knife Making • Corn Husk Dolls • Salt Glaze Pottery • Blacksmithing and Iron Working • Bird Carving • Soft Pretzelshttps://digitalcommons.ursinus.edu/pafolklifemag/1116/thumbnail.jp

Unhealthy yet Avoidable—How Cognitive Bias Modification Alters Behavioral and Brain Responses to Food Cues in Individuals with Obesity

Obesity is associated with automatically approaching problematic stimuli, such as unhealthy food. Cognitive bias modification (CBM) could beneficially impact problematic approach behavior. However, it is unclear which mechanisms are targeted by CBM in obesity. Candidate mechanisms include: (1) altering reward value of food stimuli; and (2) strengthening inhibitory abilities. Thirty-three obese adults completed either CBM or sham training during functional magnetic resonance imaging (fMRI) scanning. CBM consisted of implicit training to approach healthy and avoid unhealthy foods. At baseline, approach tendencies towards food were present in all participants. Avoiding vs. approaching food was associated with higher activity in the right angular gyrus (rAG). CBM resulted in a diminished approach bias towards unhealthy food, decreased activation in the rAG, and increased activation in the anterior cingulate cortex. Relatedly, functional connectivity between the rAG and right superior frontal gyrus increased. Analysis of brain connectivity during rest revealed training-related connectivity changes of the inferior frontal gyrus and bilateral middle frontal gyri. Taken together, CBM strengthens avoidance tendencies when faced with unhealthy foods and alters activity in brain regions underpinning behavioral inhibition.</jats:p

Unhealthy yet Avoidable—How Cognitive Bias Modification Alters Behavioral and Brain Responses to Food Cues in Individuals with Obesity

Obesity is associated with automatically approaching problematic stimuli, such as unhealthy food. Cognitive bias modification (CBM) could beneficially impact problematic approach behavior. However, it is unclear which mechanisms are targeted by CBM in obesity. Candidate mechanisms include: (1) altering reward value of food stimuli; and (2) strengthening inhibitory abilities. Thirty-three obese adults completed either CBM or sham training during functional magnetic resonance imaging (fMRI) scanning. CBM consisted of implicit training to approach healthy and avoid unhealthy foods. At baseline, approach tendencies towards food were present in all participants. Avoiding vs. approaching food was associated with higher activity in the right angular gyrus (rAG). CBM resulted in a diminished approach bias towards unhealthy food, decreased activation in the rAG, and increased activation in the anterior cingulate cortex. Relatedly, functional connectivity between the rAG and right superior frontal gyrus increased. Analysis of brain connectivity during rest revealed training-related connectivity changes of the inferior frontal gyrus and bilateral middle frontal gyri. Taken together, CBM strengthens avoidance tendencies when faced with unhealthy foods and alters activity in brain regions underpinning behavioral inhibition

Abrigo 1, Cerro El Sombrero: An Early Site in Eastern Argentina

Late Pleistocene human occupations are well represented in the Tandilia Range, Argentine Pampas. Abrigo 1 is a small shelter in close relation to the main and better-known site on the hilltop of Cerro El Sombrero, with both sites including Fishtail points. The oldest levels at the shelter dated to 13,000–12,000 calendar years ago and yielded two Fishtail points. This paper deals with the analysis of the sedimentary context, stratigraphy, artifact distribution, and site formation processes at Abrigo 1. The sedimentary record is dominantly composed of geogenic sediments with a minor participation of anthropogenic material, mainly lithic artifacts. The geogenic input includes sediments coming from the physical and chemical weathering of the rockshelter’s quartzites and windblown sediments. Pedogenesis is the prevailing site formation process. Artifact distribution, the homogeneity of the assemblage, and refitting are considered relevant to assess site integrity. The results are compared to other early cultural contexts of the immediate vicinity.Fil: Zárate, Marcelo Arístides. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Flegenheimer, Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Municipalidad de Necochea. Museo de Ciencias Naturales de Necochea; ArgentinaFil: Mehl, Adriana Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentin

Retraining automatic action tendencies in obesity

Eating behavior in obesity resembles addictive disorders in that individuals have difficulties inhibiting problematic eating behavior. They show an approach bias - a tendency to approach rather than avoid problematic stimuli. Here, we investigate the existence of such a bias towards healthy and unhealthy food in individuals with normal-weight and obesity. We further aimed to assess whether it is possible to retrain a bias, and whether training would differentially affect our two weight groups. 60 participants completed a training form of the Approach-Avoidance Task (AAT) on three consecutive days. Using a joystick, they were implicitly trained to approach healthy and to avoid unhealthy food pictures. Prior to training, individuals with obesity showed stronger approach tendencies towards food pictures than normal-weight individuals. In individuals with obesity, approach tendencies could be diminished for unhealthy food through one training session and stayed weakened for the following days. In normal-weight participants, approach tendencies towards healthy food could be enhanced over the days of training. Findings indicate that automatic approach tendencies can be changed through training, thus offering possibilities for obesity treatment. Future studies should expand on these findings, for example by including pictures of neutral objects or a no-training control condition

A randomised-controlled trial to evaluate the app-based multimodal weight-loss program zanadio for patients with obesity

Objective Although the prevalence of obesity is constantly high, the care situation for patients with obesity is still insufficient. The advent of digital, evidence-based therapies to treat obesity could help alleviate this situation. This study therefore aimed at evaluating the effectiveness of the app-based, multimodal weight loss programme zanadio. Methods To examine the effectiveness for sustained weight loss of zanadio, a randomised-controlled trial (DRKS00024415) was conducted between January 2021 and March 2022. 150 adults with obesity were randomised into an intervention group or a control group. While the participants of the intervention group used zanadio for one year, participants in the control group were not allowed to use the app during the study period but were free to start other weight-loss attempts. The primary endpoint weight change (in %) and the secondary endpoints quality of life, well-being, and waist-to-height ratio, were assessed every three months (T0, T1, T2, T3, T4) via telephone interviews and online questionnaires. For the statistical analyses intention-to-treat and per-protocol analyses were performed. Results After 12 months, based on an intention-to-treat analysis, participants of the intervention group lost on average -7.75% (95% CI=[-9.66, -5.84]) of their initial body weight, while the control group showed no weight loss at the end of the study (M=0.00%, [-1.98, 1.99]). Importantly, the intervention group achieved a clinically relevant (< 5%) and significant weight reduction. These results were confirmed by a per-protocol analysis. Moreover, all secondary endpoints improved significantly in the intervention group, with significantly greater improvements in well-being and waist-to-height ratio than in the control group. Conclusion This study showed that adults with obesity who have used zanadio achieved a significant and clinically relevant weight loss within 12 months and further improved other obesity-related health variables compared to a wait-list control group. Limitations of the study are the mainly female sample and the exclusively self-reported outcome measures. Due to its effectiveness and flexible applicability, zanadio represents a low-threshold and widely accessible treatment offer for patients in Germany, that might alleviate the present care gap for patients with obesity.Peer reviewe