Improvements in BepiColombo and JUICE radio science experiments with a multi-station tracking configuration for the reduction of Doppler noise

Radio science experiments for planetary geodesy mostly rely on measurements of the Doppler shift of microwave signals sent to a spacecraft by an Earth station, and retransmitted back coherently in phase to the same antenna (two-way link). The retransmitted signal can also be received by a different station in a listen-only configuration (three-way link). In state-of-the-art tracking systems, such as the ones will be used on the future ESA's missions JUICE and BepiColombo, the Doppler error budget is dominated by local noise sources arising at the ground-station, in particular tropospheric scintillation and unmodeled motions of the antenna's structure. In this work, a novel technique aimed at reducing these disturbances is analyzed, with particular emphasis on its benefits to BepiColombo's and JUICE's radio science experiments. The method, referred to as Time-Delay Mechanical-noise Cancellation (TDMC), relies on simultaneous two-way and three-way spacecraft tracking, the latter employing a stiffer listen-only antenna with better mechanical stability and located in a favorable dry region more immune to tropospheric noise. In fact, a proper linear combination of time-shifted observables from the two-way and three-way links can replace local noises of the two-way ground-station with those coming from the listen-only antenna, translating into increased accuracy of the final measurements, while preserving the original Doppler content. We show the results of covariance analyses performed with a multi-arc weighted least square estimator for the entire BepiColombo's Hermean phase and JUICE's flybys of Callisto. We compare the two solutions obtained with and without the application of the TDMC technique. For BepiColombo and JUICE radio science experiments, the two-way links are baselined from the 35-m DSA-3 (Malargüe, Argentina) and the 34-m DSS 25 (Goldstone, California). For the three-way link, we select the 12-m Large Latin American Millimeter Array (LLAMA) antenna for three reasons: 1) its mechanical rigidity with respect to large beam-waveguide antennas, 2) its unique position in the extremely dry Puna de Atacama desert, that assures low tropospheric noise, and 3) its limited longitudinal separation from the two other ground-stations, granting sufficient common visibility time to perform the requested combination of the observables. Besides its noise-reduction effect, enabling unprecedented levels of accuracy on Doppler measurements, TDMC provides also a back-up for unique events: a crucial satellite flyby or a specific passage over a site of particular geophysical interest. Indeed, measurements become virtually independent of unfavorable meteorological conditions at the transmitting station

Chronic, acute and acute-on-chronic pain prevalence in a tertiary care hospital setting

OBJECTIVE: The aim of the study was to develop appropriate pain therapy and prevention plans; pain needs to be understood in terms of prevalence and associated predictor factors in hospital and primary care. The purpose of our research was to assess the prevalence of chronic, acute, and acute-on-chronic pain, and ascertain the effects of several factors on the likelihood of pain in an Italian Tertiary Care Hospital. PATIENTS AND METHODS: This is a prevalence study in which the primary outcome was the prevalence rate of chronic pain inpatients. Fisher’s exact tests and binomial logistic regression were performed for the prevalence measures, and to ascertain the effects of Hospital Unit, sex, age, surgery and preexisting chronic pain on the likelihood of pain during the hospitalization, respectively. RESULTS: Chronic pain was reported in one-fifth of inpatients [21.7% (95% CI: 0.1764, 0.2625)], with a high prevalence of pain-related interference on sleep and emotional status. Nearly 70% of chronic pain patients accused acute-on-chronic pain [15.3% (95% CI: 0.1178, 0.1934)]. High pain prevalence rates were assessed at the time of the interview (37.3%; 95% CI: 0.3234, 0.4239) and in the last 24 hours of hospitalization (53.3%; 95% CI: 0.4814, 0.5850). A 2.7 and 2.6 higher odds to suffer from pain during the hospitalization were associated with surgery, and preexisting chronic, respectively. CONCLUSIONS: This study raises awareness of the necessity to refine pain assessment and management in hospital and outpatient services. The promotion and enhancement of hospital-territory integration are essential for improving pain prescribing practices and increasing patient safety

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes

C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular hemolysis reducing clinical benefits. Despite the uniform deficiency of CD55 and of CD59, there are always two distinct populations of PNH RBCs, with (C3+) and without (C3-) C3 binding

A Web Graphical Tool for the Integration of Unbalanced Biomolecular Networks

1 MOTIVATION - The automated protein function prediction problem (AFP) is mainly characterized by the unbalance between annotated and unannotated genes and the integration of multiple data sources. The “informativeness” of each network/source may depend on the considered protein function, and neglecting the unbalance between annotated and unannotated proteins may thereby lead to strong decay in performance. Recently, the UNIPred algorithm [1] was proposed to integrate in a function-specific fashion the input networks by automatically handling the data imbalance. A relevant challenge in this context is the appropriate visualization and interpretation of the resulting network. Indeed, the network size can be extremely big and their simple visualization, with off-theshelf graphical visualization tools (e.g. GraphViz, GeneMania) produces a cloud of points hard to interpret and handle within a browser (lack of memory). To face the problem, here we propose a web-tool implementing UNIPred and introducing an approximate visualization of the graph. Having the system embedded different levels of abstraction, the user can both decide the part of the graph to explore, and click on the corresponding part to obtain a new enhanced visualization. 2. METHODS - The different input networks have been represented and stored according to the relational model. Efficient PL/SQL procedures calculate subgraphs centered on a vertex and with a given radius. An R software gathers the networks from the database, integrate them according to the UNIPred algorithm and store the results back in the database. Relying on this infrastructure, a web graphical tool has been implemented that offers different facilities to the user for the network management, their integration, visualization and exploration. In particular, both ``vertex-centric" exact and approximate visualizations are provided. With ``vertex-centric" [2] visualization approach we mean that the user can specify a vertex, named target, he wishes to explore the result of the integration, and the size of the subnetwork to extract. The extracted network can be shown to the user when its size is small and the available canvas is big enough for its visualization. Otherwise, approximate visualization techniques are used. For example, the target node can be connected with bubbles of different sizes that distribute the nodes of the subgraph relying on the weight of the outgoing edges and the distance from the target. Clicking on one of the bubbles, the visualization can be then expanded by showing other bubbles or single nodes. 3 RESULTS - We have realized a Web tool offering different facilities for the exploration of protein networks, their efficient integration using the UNIPred algorithm in a Web-based environment, and the exploration of the resulting network by means of a vertex-centric visualization approach. The visualization can be exact or approximate depending on the size of the network and of the drawing canvas. In the left part of Figure 1 a target is shown in the center and then four bubbles that partition the vertex at distance 1 from the target depending on the weight of the outgoing edges. This representation points out how much the co-functionality confidence degree has been propagated (or not) from the target node. Moreover, by clicking on one of the bubbles, it is split again in 4 parts, thus allowing multiple “vertex-centric” views at different resolution levels

The Top-Implart Proton Linear Accelerator: Interim Characteristics of the 35 Mev Beam

In the framework of the Italian TOP-IMPLART project (Regione Lazio), ENEA-Frascati, ISS and IFO are developing and constructing the first proton linear accelerator based on an actively scanned beam for tumor radiotherapy with final energy of 150 MeV. An important feature of this accelerator is modularity: an exploitable beam can be delivered at any stage of its construction, which allows for immediate characterization and virtually continuous improvement of its performance. Currently, a sequence of 3 GHz accelerating modules combined with a commercial injector operating at 425 MHz delivers protons up to 35 MeV. Several dosimetry systems were used to obtain preliminary characteristics of the 35-MeV beam in terms of stability and homogeneity. Short-term stability and homogeneity better than 3% and 2.6%, respectively, were demonstrated; for stability an improvement with respect to the respective value obtained for the previous 27 MeV beam

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes. Danicopan is a first-in-class oral proximal, complement alternative pathway factor D inhibitor. Therapeutic factor D inhibition was designed to control intravascular hemolysis and prevent C3-mediated extravascular hemolysis. In this open-label, phase II, dose-finding trial, ten untreated PNH patients with hemolysis received danicopan monotherapy (100-200 mg thrice daily). Endpoints included changes in the concentrations of lactate dehydrogenase (LDH) at day 28 (primary endpoint), of LDH at day 84, and of hemoglobin. Safety, pharmacokinetics/ pharmacodynamics, and patient-reported outcomes were assessed. Ten patients reached the primary endpoint; two later discontinued treatment: one because of a serious adverse event (elevated aspartate aminotransferase/ alanine aminotransferase coincident with breakthrough hemolysis, resolving without sequelae) and one for personal reasons unrelated to safety. Eight patients completed treatment. Intravascular hemolysis was inhibited, as demonstrated by a mean decrease of LDH (5.7 times upper limit of normal [ULN] at baseline vs. 1.8 times ULN at day 28 and 2.2 times ULN at day 84; both P<0.001). Mean baseline hemoglobin, 9.8 g/dL, increased by 1.1 (day 28) and 1.7 (day 84) g/dL (both P<0.005). No significant C3 fragment deposition occurred on glycosylphosphatidylinositol- deficient erythrocytes. Mean baseline Functional Assessment of Chronic Illness Therapy–Fatigue score, 34, increased by 9 (day 28) and 13 (day 84) points. The most common adverse events were headache and upper respiratory tract infection. These phase II, monotherapy data show that proximal inhibition with danicopan provides clinically meaningful inhibition of intravascular hemolysis and increases hemoglobin concentration in untreated PNH patients, without evidence of C3-mediated extravascular hemolysis. This trial was registered at www.clinicaltrials.gov (#NCT03053102)

State-of-the-art:AI through the (artificial) Artist’s Eye

This paper builds on the premise that art has a significant role to play in engaging with and exploring new technologies and in contributing to interdisciplinary conversations. Artists have often been pioneers in reflecting upon social and technological transformations by creating work that makes explicit the dangers, but also the exciting possibilities ushered in by innovation. After having, albeit briefly, traced the history of art engagement with technology (computer/net-art, generative art), the paper will focus on AI-art, now defined as GAI-art, to understand whether artificial intelligence is “set to become art’s next medium?” The question was prompted by the sale at Christie’s in October 2018 for $432,500 of a portrait entitled Edmund de Belamy, a work created by an algorithm called Generative Adversarial Network (GAN). The source code used by the Paris based art collective Obvious (borrowed from AI researcher/artist Robbie Barrat) to create the “artwork” triggered a debate as to the authenticity, authorship and ethics of using GAN to produce AI-art. The paper will contribute to such debate by exploring also the implications of systems more sophisticated than GAN - which seem to be able to act as “autonomous artificial artists” and produce new styles of art - and by showcasing the works of some of the most representative machine vision researchers/artists - Anna Ridler and Mario Klingeman, among others. AI artworks raise major philosophical questions, the meaning to be human in a hyper-connected world and the true nature of human creativity. In fact conceptualising AI through the artificial artist’s eye might even challenge our understanding of what it means to be human

Gravity, Geodesy and Fundamental Physics with BepiColombo’s MORE Investigation

The Mercury Orbiter Radio Science Experiment (MORE) of the ESA mission BepiColombo will provide an accurate estimation of Mercury’s gravity field and rotational state, improved tests of general relativity, and a novel deep space navigation system. The key experimental setup entails a highly stable, multi-frequency radio link in X and Ka band, enabling two-way range rate measurements of 3 micron/s at nearly all solar elongation angles. In addition, a high chip rate, pseudo-noise ranging system has already been tested at 1-2&nbsp;cm accuracy. The tracking data will be used together with the measurements of the Italian Spring Accelerometer to provide a pseudo drag free environment for the data analysis. We summarize the existing literature published over the past years and report on the overall configuration of the experiment, its operations in cruise and at Mercury, and the expected scientific results

Gravity, Geodesy and Fundamental Physics with BepiColombo’s MORE Investigation

open40siThe Mercury Orbiter Radio Science Experiment (MORE) of the ESA mission BepiColombo will provide an accurate estimation of Mercury’s gravity field and rotational state, improved tests of general relativity, and a novel deep space navigation system. The key experimental setup entails a highly stable, multi-frequency radio link in X and Ka band, enabling two-way range rate measurements of 3 micron/s at nearly all solar elongation angles. In addition, a high chip rate, pseudo-noise ranging system has already been tested at 1-2&nbsp;cm accuracy. The tracking data will be used together with the measurements of the Italian Spring Accelerometer to provide a pseudo drag free environment for the data analysis. We summarize the existing literature published over the past years and report on the overall configuration of the experiment, its operations in cruise and at Mercury, and the expected scientific results.openIess L.; Asmar S.W.; Cappuccio P.; Cascioli G.; De Marchi F.; di Stefano I.; Genova A.; Ashby N.; Barriot J.P.; Bender P.; Benedetto C.; Border J.S.; Budnik F.; Ciarcia S.; Damour T.; Dehant V.; Di Achille G.; Di Ruscio A.; Fienga A.; Formaro R.; Klioner S.; Konopliv A.; Lemaitre A.; Longo F.; Mercolino M.; Mitri G.; Notaro V.; Olivieri A.; Paik M.; Palli A.; Schettino G.; Serra D.; Simone L.; Tommei G.; Tortora P.; Van Hoolst T.; Vokrouhlicky D.; Watkins M.; Wu X.; Zannoni M.Iess L.; Asmar S.W.; Cappuccio P.; Cascioli G.; De Marchi F.; di Stefano I.; Genova A.; Ashby N.; Barriot J.P.; Bender P.; Benedetto C.; Border J.S.; Budnik F.; Ciarcia S.; Damour T.; Dehant V.; Di Achille G.; Di Ruscio A.; Fienga A.; Formaro R.; Klioner S.; Konopliv A.; Lemaitre A.; Longo F.; Mercolino M.; Mitri G.; Notaro V.; Olivieri A.; Paik M.; Palli A.; Schettino G.; Serra D.; Simone L.; Tommei G.; Tortora P.; Van Hoolst T.; Vokrouhlicky D.; Watkins M.; Wu X.; Zannoni M