Polyunsaturated fatty acids in atrial fibrillation: Looking for the proper candidates

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionAtrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice with growing prevalence in developed countries. Several medical and interventional therapies, such as atrial specific drugs and pulmonary vein isolation, have demonstrated prevention of recurrences. However, their suboptimal long-term success and significant rate of secondary effects have led to intensive research in the last decade focused on novel alternative and supplemental therapies. One such candidate is polyunsaturated fatty acids (PUFAs). Because of their biological properties, safety, simplicity, and relatively cheap cost, there is a special clinical interest in omega-3 PUFAs as a possible antiarrhythmic agent. Obtained from diets rich in fish, they represent one of the current supplemental therapies. At the cellular level, an increasing body of evidence has shown that n-3 PUFAs exert a variety of effects on cardiac ion channels, membrane dynamic properties, inflammatory cascade, and other targets related to AF prevention. In this article, we review the current basic and clinical evidence pertinent to n-3 PUFAs in AF treatment and prevention.We also discuss controversial outcomes among clinical studies and propose specific subsets of AF patients who will benefit most from n-3 PUFAsNHLBI Grant K99-HL105574 to SFN and the Alfonso Martín Escudero Foundation Grant to DF

« Le duo des dieux » : rhétoriques et montage des discours Bush / Ben Laden dans 11 septembre 2001 de Michel Vinaver

Le 11 septembre 2001 étant, comme le note Michel Vinaver, « un événement que la pensée ne réussit pas à circonscrire », il pose un défi à la représentation, notamment discursive. D’ailleurs, de par sa nature, l’acte marque un retour à la violence primitive, par-delà la convention de la verbalisation des conflits qui assoit le règne de la rhétorique en politique. Or, c’est une profusion chaotique d’images, mais aussi de discours, qui déferle dans la couverture médiatique de l’événement. Cherch..

Une Vie secrète polyphonique de P. Quignard

Dans Vie secrète, Pascal Quignard mêle l’essai, les fragments historiques ou biographiques à la narration autobiographique. Mais ce qui frappe surtout chez l’auteur, fils d’enseignants de lettres classiques ayant connu dans son enfance des épisodes d’autisme, c’est la profusion des citations des Anciens. La réflexion se construit au gré des pérégrinations étymologiques gréco-latines, qui déconstruisent le langage quotidien et mettent à jour les sources ‘utérines’ de la pensée. Ainsi s’opère subrepticement un retour sur soi, dans la quête incessamment vaine « du propre à nous en nous », des lieux d’origine – en l’occurrence le Havre en ruines où a grandi l’auteur, nourri des sonorités latines et marqué par l’adieu à diverses figures féminines aimées. Nous tenterons de démêler, dans Vie secrète, l’articulation conflictuelle et/ou fusionnelle entre l’intime et l’extime, le soi et l’autre, la voix silencieuse de Quignard et la trace des voix absentes qui hantent son œuvre

An assessment of anti-staphylococcal, anti-mycobacterial and anti-candidal properties in fungal isolates of the big brown bat (Eptesicus fuscus) microbiome

1 online resource (40 pages) : colour illustrationsIncludes abstract and appendices.Includes bibliographical references (pages 36-38).Antibiotic resistance is becoming an increasing problem in global health. The emergence of antibiotic-resistant bacterial and fungal infections is expected to increase over the next few years. In an effort to develop therapies to counteract this issue, previously unexplored environmental microbes are assessed in their anti-candidal, anti-staphylococcal and anti-mycobacterial properties. Five strains from the big brown bat microbiome are cross-cultured with three pathogenic strains: Staphylococcus aureus, Mycobacterium smegmatis, and Candida albicans. These pathogenic strains act as proxies for antibiotic-resistant pathogens. Working under the presumption of quorum-sensing occurring between microbes in close proximity, cross-cultures are conducted with the intent of activating dormant pathways. Bat strain growth and phenotypic changes are assessed in these cross-cultures and the possibilities of anti-pathogenic properties in bat strains are determined based on these findings. Two of the five bat strains studied have a strong likelihood of possessing anti-pathogenic properties. The remaining bat strains show promise in further investigations as well, but not to the same extent based on findings