Alien Registration- Nowlen, Edwin (Newport, Penobscot County)

https://digitalmaine.com/alien_docs/8069/thumbnail.jp

Identifying Pathogenic Variants in Hereditary Cancer Syndrome Genes via Tumor Molecular Profiling

Tumor molecular profiling is often performed in order to direct cancer treatment options. However, because many of the genes analyzed on tumor molecular profiling overlap with genes known to be associated in the germline with hereditary cancer predisposition syndromes, tumor molecular profiling can unknowingly uncover germline predisposition to cancer development. In this study, we determined the number of patients with pathogenic variants (PVs) identified in BRCA1 and BRCA2 (BRCA1/2) via tumor molecular profiling at The University of Texas MD Anderson Cancer Center, then performed a retrospective chart review to determine the proportion of such patients that received germline testing and had germline PVs identified. We found that 3.78% (13/2,990; 95% CI 3.09-4.46%) of tumor-only testing reports identified PVs in BRCA1/2, 38.94% (44/113; 95% CI 29.95-47.93%) of patients with pathogenic variants in BRCA1/2 had germline testing, and 63.64% (28/44; 95% CI 49.42-77.85%) of patients with germline testing had germline PVs in BRCA1/2. Patients with cancer diagnoses related to BRCA1/2 were more likely to have had germline testing (72.73% of patients with testing had HBOC-related tumors vs. 36.23% of those without testing, p BRCA1/2 mutations, particularly in non-BRCA1/2 associated cancer types

Alien Registration- Nowlen, Mary E. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/22239/thumbnail.jp

Learning from Hispanic Mentees: A Reflection on Cultural and Socioeconomic Differences

Oakland University William Beaumont - Hispanic Newcomer Outreach mentoring program offers medical students the opportunity to mentor local Hispanic teenagers. Here, we describe the experience of two medical students in the program with their mentees. Through the weekly phone calls and weekend activities, their relationships strengthened and the mentors learned invaluable lessons about the effects of socioeconomic status, gender roles, and culture that could not be learned from a classroom. This program helped shape their ever-evolving cultural humility, which highlights the importance of long-term, meaningful experiences with people from different cultural and socioeconomic backgrounds in medical education.&nbsp

Une introduction pour la comptabilité française

Accounting practices differ between France and the United States. Financial statements are formatted similarly on the surface, but when one investigates further, they quickly realize that the contents of the statements are very different. Also, the laws and regulations in France require different practices than are required in the United States. However, the two are becoming more similar with the influence of the IFRS, which creates the accounting laws for the world. A lot of changes have presented themselves during the 21st century in France, specifically with stronger monitoring and technology. The accounting practice is not perfect, but the system that enables change encourages a much stronger practice in the future

An assessment of fire vulnerability for aged electrical relays

There has been some concern that, as nuclear power plants age, protective measures taken to control and minimize the impact of fire may become ineffective, or significantly less effective, and hence result in an increased fire risk. One objective of the Fire Vulnerability of Aged Electrical Components Program is to assess the effects of aging and service wear on the fire vulnerability of electrical equipment. An increased fire vulnerability of components may lead to an overall increase in fire risk to the plant. Because of their widespread use in various electrical safety systems, electromechanical relays were chosen to be the initial components for evaluation. This test program assessed the impact of operational and thermal aging on the vulnerability of these relays to fire-induced damage. Only thermal effects of a fire were examined in this test program. The impact of smoke, corrosive materials, or fire suppression effects on relay performance were not addressed in this test program. The purpose of this test program was to assess whether the fire vulnerability of electrical relays increased with aging. The sequence followed for the test program was to: identify specific relay types, develop three fire scenarios, artificially age several relays, test the unaged and aged relays in the fire exposure scenarios, and compare the results. The relays tested were Agastat GPI, General Electric (GE) HMA, HGA, and HFA. At least two relays of each type were artificially aged and at least two relays of each type were new. Relays were operationally aged by cycling the relay under rated load for 2,000 operations. These relays were then thermally aged for 60 days with their coil energized

Metabolomic Profile Comparison of Osteoarthritic and Traumatically Injured Synovial Joints

The widespread prevalence of degenerative joint diseases, such as osteoarthritis, characterized as a leading cause of disability, affects thousands of people around the world. Post-traumatic arthritis is a joint condition following joint injuries such as fractures or dislocations. The risk of developing arthritis is higher for people who have suffered an injury to their joints than for those who have never experienced such an injury. The exact mechanisms causing joint degradation remain unknown. Recent studies have applied metabolomics to the study of OA, and several metabolism-related pathways, as well as specific metabolic markers, have been identified as contributing factors. Although OA and post-traumatic OA are common across the world and have been extensively studied, only a partial understanding exists of the metabolites responsible for both. . In this study, 13 different patients' synovial fluid samples will be collected. Seven contain the osteoarthritis pathology, one is from a joint that has undergone traumatic injury, and five are healthy control samples. By comparing the synovial fluid of the two experimental categories to controls, this study aims to identify possible differences and similarities in metabolite characteristics and populations in the biofluid. A LC-MS analysis will be performed on the samples and metabolite features that distinguish between cohorts will be identified using univariate and multivariate statistical methods. The study will employ pathway enrichment analyses to identify metabolic pathways impacted by injury and osteoarthritis. Biomarkers explored in this research may help diagnose OA and detect early symptoms associated with OA after a traumatic injury

Impact of mask wearing during high-intensity exercise on post-exercise hemodynamics

Background: Few studies examining face mask wearing during high-intensity interval exercise (HIE) have measured blood pressure (BP) and cardiac output (Q) during exercise and none have examined these variables post-exercise. Methods: Participants were randomly assigned to complete four exercise and two control conditions while wearing different face masks. Participants followed a 4x4 protocol on a cycle ergometer. Participants exercised at 85% of VO2max for 4-min, followed by a 3-min rest, repeated four times. Measurements of Q, systemic vascular resistance (SVR), and BP were measured pre-exercise for 20-min, during exercise, and postexercise for 60-min. Linear mixed models were used to detect differences between conditions. Results: Ten young (20.3 ± 1.4 yr.) male (n = 5) and female (n = 5) participants with an average BMI of 28.1 ± 7.3 kg/m2 and VO2max of 37.0 ± 7.1 ml.kg-1.min-1 completed this. There were no group differences during exercise on outcomes of Q, SVR, HR, SBP, DBP, MAP, or RPE (all p > .05). During exercise, EXS-N95 had a lower SV than CON-E (p = .014) and EXS-CL (p = .006). All mask conditions had a higher post-exercise HR than CON-E (all p > .05). Only EXS-SUR differed in post-exercise brachial SBP compared to CON-E (3.1 ± 1.6 mmHg, p < .043). Of the exercise conditions, only EXS-N95 differed from CON-E with an increase of 2.0 ± .88 mmHg for brachial DBP (p = .022) and 2.1 ± .92 mmHg for central DBP (p = .022), SV (-11.8 ± 3.5 mL.min-1, p < .001), Q (-.52 ± .26 L.min-1, p = .045), and SVR (73.7 ± 29.8 Dyn.s/cm5, p = .014). Conclusion: The current study shows that in healthy populations, wearing a face covering of any type during HIE does not impactfully change the hemodynamic response during exercise or recovery period