Survival of Political Leadership

We focus on political violence as a mechanism that allows the political leader to fight off opposition and increase his chances of re-election. In a collusive equilibrium, the leader allocates a bribe to the army, and the latter responds by producing political violence. Such an equilibrium is more likely, the larger are the public resources available to the leader; the lower is army�s potential punishment and salary offered by the opposition regime; the more severe is the incumbent�s potential punishment; and when the political leader is sufficiently patient, but the army is shortsighted enough.

Citizen science for cuneiform studies

This paper examines the potential applications of Citizen Science and Open Linked Data within a critical Web Science framework. Described here is a work-inprocess concerning an interdisciplinary, multiinstitutional project for the digitization, annotation and online dissemination of a large corpus of written material from ancient Mesopotamia. The paper includes an outline of the problems presented by a large, heterogeneous and incomplete dataset, as well as a discussion of the potential of Citizen Science as a potential solution, combining both technical and social aspects. Drawing inspiration from other successful Citizen Science projects, the current paper suggests a process for capturing and enriching the data in ways which can address not only the challenges of the current data set, but also similar issues arising elsewhere on the wider Web

Triggering trigeminal neuralgia

Introduction: Although it is widely accepted that facial pain paroxysms triggered by innocuous stimuli constitute a hallmark sign of trigeminal neuralgia, very few studies to date have systematically investigated the role of the triggers involved. In the recently published diagnostic classification, triggered pain is an essential criterion for the diagnosis of trigeminal neuralgia but no study to date has been designed to address this issue directly. In this study, we set out to determine, in patients with trigeminal neuralgia, how frequently triggers are present, which manoeuvres activate them and where cutaneous and mucosal trigger zones are located. Methods: Clinical characteristics focusing on trigger factors were collected from 140 patients with trigeminal neuralgia, in a cross-sectional study design. Results: Provocation of paroxysmal pain by various trigger manoeuvres was reported by 136 of the 140 patients. The most frequent manoeuvres were gentle touching of the face (79%) and talking (54%). Trigger zones were predominantly reported in the perioral and nasal region. Conclusion: This study confirms that in trigeminal neuralgia, paroxysmal pain is associated with triggers in virtually all patients and supports the use of triggers as an essential diagnostic feature of trigeminal neuralgia

Trigeminal neuralgia: new classification and diagnostic grading for practice and research

Trigeminal neuralgia (TN) is an exemplary condition of neuropathic facial pain. However, formally classifying TN as neuropathic pain based on the grading system of the International Association for the Study of Pain is complicated by the requirement of objective signs confirming an underlying lesion or disease of the somatosensory system. The latest version of the International Classification of Headache Disorders created similar difficulties by abandoning the term symptomatic TN for manifestations caused by major neurologic disease, such as tumors or multiple sclerosis. These diagnostic challenges hinder the triage of TN patients for therapy and clinical trials, and hamper the design of treatment guidelines. In response to these shortcomings, we have developed a classification of TN that aligns with the nosology of other neurologic disorders and neuropathic pain. We propose 3 diagnostic categories. Classical TN requires demonstration of morphologic changes in the trigeminal nerve root from vascular compression. Secondary TN is due to an identifiable underlying neurologic disease. TN of unknown etiology is labeled idiopathic. Diagnostic certainty is graded possible when pain paroxysms occur in the distribution of the trigeminal nerve branches. Triggered paroxysms permit the designation of clinically established TN and probable neuropathic pain. Imaging and neurophysiologic tests that establish the etiology of classical or secondary TN determine definite neuropathic pain

Altered cortical processing of observed pain in patients with fibromyalgia syndrome

Fibromyalgia syndrome (FMS) is characterized by widespread chronic pain, fatigue, sleep disorders, and cognitive-emotional disturbance. Patients with FMS exhibit increased sensitivity to experimental pain and pain-related cues, as well as deficits in emotional regulation. The present study investigated the spatiotemporal patterns of brain activations for observed pain in 19 patients with FMS and 18 age-matched, healthy control individuals using event-related potential analysis. Patients with FMS attributed greater pain and unpleasantness to pain pictures, relative to healthy control participants. An augmented late positive potential (LPP) component (>500 milliseconds) was found in patients viewing both pain and nonpain pictures, and this amplitude difference in the LPP covaried with perceived unpleasantness of pictures. Mid-latency potentials (250–450 milliseconds) demonstrated similar amplitude increases of positive potentials in the FMS patient group. By contrast, the short-latency positive potential (140 milliseconds) was reduced in patients with FMS relative to healthy control participants. Results suggest amplitude increases to mid- to long-latency cortical activations in patients with FMS, which are known to reflect emotional control and motivational salience of stimuli. Perspective Patients with FMS demonstrate increased activations associated with pain and nonpain pictures. The findings suggest that even innocuous, everyday visual stimuli with somatic connotations may challenge the emotional state of patients with FMS. Our study points toward the importance of cognitive-emotional therapeutic approaches for the treatment of FMS

Trigeminal neuralgia: New classification and diagnostic grading for practice and research

Trigeminal neuralgia (TN) is an exemplary condition of neuropathic facial pain. However, formally classifying TN as neuropathic pain based on the grading system of the International Association for the Study of Pain is complicated by the requirement of objective signs confirming an underlying lesion or disease of the somatosensory system. The latest version of the International Classification of Headache Disorders created similar difficulties by abandoning the term symptomatic TN for manifestations caused by major neurologic disease, such as tumors or multiple sclerosis. These diagnostic challenges hinder the triage of TN patients for therapy and clinical trials, and hamper the design of treatment guidelines. In response to these shortcomings, we have developed a classification of TN that aligns with the nosology of other neurologic disorders and neuropathic pain. We propose 3 diagnostic categories. Classical TN requires demonstration of morphologic changes in the trigeminal nerve root from vascular compression. Secondary TN is due to an identifiable underlying neurologic disease. TN of unknown etiology is labeled idiopathic. Diagnostic certainty is graded possible when pain paroxysms occur in the distribution of the trigeminal nerve branches. Triggered paroxysms permit the designation of clinically established TN and probable neuropathic pain. Imaging and neurophysiologic tests that establish the etiology of classical or secondary TN determine definite neuropathic pain

International trade and regional integration : a case study of selected Southern African economies

Siirretty Doriast

Pharmacological treatment of neuropathic pain in older persons

Interest and research into the mechanisms and treatment of neuropathic pain have increased during recent years, but current treatment is still far from satisfactory (Dworkin et al 2003; Attal et al 2006). The European Federation of Neurological Societies (EFNS) Task Force recently published guidelines for the pharmacological treatment of neuropathic pain (Attal et al 2006). However, no particular consideration is given as to how the recommendations are applicable to the elderly population. This paper will review the guidelines in relation to this population and evaluate the existing evidence relating to the use of these drugs in older persons

A bright future for colloidal quantum dot lasers

A

Event-Driven Imaging in Turbid Media: A Confluence of Optoelectronics and Neuromorphic Computation

In this paper a new optical-computational method is introduced to unveil images of targets whose visibility is severely obscured by light scattering in dense, turbid media. The targets of interest are taken to be dynamic in that their optical properties are time-varying whether stationary in space or moving. The scheme, to our knowledge the first of its kind, is human vision inspired whereby diffuse photons collected from the turbid medium are first transformed to spike trains by a dynamic vision sensor as in the retina, and image reconstruction is then performed by a neuromorphic computing approach mimicking the brain. We combine benchtop experimental data in both reflection (backscattering) and transmission geometries with support from physics-based simulations to develop a neuromorphic computational model and then apply this for image reconstruction of different MNIST characters and image sets by a dedicated deep spiking neural network algorithm. Image reconstruction is achieved under conditions of turbidity where an original image is unintelligible to the human eye or a digital video camera, yet clearly and quantifiable identifiable when using the new neuromorphic computational approach