Association of Cytomegalovirus (CMV) Infection with Guillain- Barré Syndrome (GBS) In Tertiary Care Hospital (BSMMU) of Bangladesh

Background: Guillain-Barré syndrome (GBS) usually preceded by infections, in particular cytomegalovirus (CMV). It may occur by primary infection, reinfection or by reactivation of CMV. Objective: The aim of the present study was to evaluate the association of Guillain-Barré syndrome (GBS) with Cytomegalovirus (CMV) infection.&#x0D; Methodology: This case control study was carried out in the indoor and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 1st January 2010 to 31st December 2011 for the duration of two years. All patients with GBS, who attended in neurology OPD or inpatient department at BSMMU during the study period, fulfilling the inclusion and exclusion criterias were included in this study. Age &amp; sex matched volunteers, patients attendants, patients other than GBS who were nondiabetic, had no renal or hepatic diseases or family history of polyneuropathy were included in control group.&#x0D; Results: A total number of 78 respondents of which 39 patients were taken as cases and rest 39 were taken as controls who appeared in neurology OPD or inpatient department at BSMMU during the study period, fulfilling the inclusion and exclusion criterias were included in this study. The mean age ± SD of case and control groups were 30.82 ± 12.56 and 31.00 ± 12.77 years respectively (p=0.950). In case group the history of respiratory tract infection was present in 46.2% cases and absent in control group (p=0.001). In case group the history of gastroenteritis was present in 28.2% cases and absent in control group (p=0.001). In case group the history of fever was present in 30.8% cases and absent in control group (p=0.001). Anti-CMV IgM antibody was positive in 5.1% cases. Four fold rise of IgG in case group was present in 10.3% cases and absent in control group (p=0.040). Confirmed CMV infected GBS cases were 15.4% and absent in control group (p=0.011).&#x0D; Conclusion: The findings of this study permit to conclude that there is a significant association of Guillain-Barré syndrome (GBS) with Cytomegalovirus (CMV) infection.&#x0D; Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 88-97</jats:p

Association Between Serum C- Reactive Protein With Migraine: A Case Control Study

Objective: The present case-control study was undertaken to find the association between serum level of CRP and attack of migraine.&#x0D; Methods: The study was carried out at the Headache Clinic and Outpatient Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka over a period of 2 years from January 2010 to December 2011. Migraine patients attending at the above mentioned places were enrolled as cases, while apparently healthy attendants of cases and other healthy persons, who did not have any history of migraine, were included as control. Based on predefined enrollment criteria, a total of 163 subjects were included in the study. Of them 87 were cases and 76 were controls. The serum levels of CRP of both cases and controls were measured and a serum level of &gt; 6 mg/L was considered as raised/ elevated CRP. Levels of CRP were compared between groups (case and control) using appropriate statistical tests.&#x0D; Result: The findings of the study showed that the age and sex distribution of case and control groups were almost comparable. The behavioral factors like food or smoking habit and tobacco leaf chewing had no difference between the groups. Over 20% of migraine patients had abnormally high CRP as compared to 7.9% in the control group (p = 0.021). The migraine patients were 3(95% CI = 1.1 - 8.1) times more likely to be associated with raised CRP (&gt; 6 mg/L) than their healthy counterparts. There were 7 migraine patients with aura and 80 without aura. The level of CRP was not found to be associated with type of migraine (with or without aura) (p = 0.960).&#x0D; Conclusion: Every one in five patients exhibits abnormally high CRP. The level of CRP does not vary whether the migraine is being associated with or without aura. The migraineurs carry higher risk of developing elevated CRP than their normal counterparts.&#x0D; Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 1-8</jats:p

Association of Serum Uric Acid with Parkinson Disease

Background: Several studies have identified that low serum uric acid (UA) is a possible risk factor for Parkinson Disease (PD). The aim of my study was based on evaluation of association of serum uric acid with Parkinson Disease (PD).&#x0D; Objective: To evaluate the association of serum uric acid with Parkinson Disease(PD).&#x0D; Methodology: It was a case control study carried out in the Department of Neurology of Bangabandhu Sheikh Mujib Medical University. A total 50 patients of PD aged 45 years or above were taken as cases; and age and sex matched 50 healthy subjects or patients other than PD were taken as control. Serum UA levels were measured in both groups. Besides, any association was searched between serum UA with age, sex, duration and stage of PD, BMI and dietary habit.&#x0D; Results: The mean serum uric acid level in case group was 4.25±1.00 mg/dl and that of control group was 4.73±1.29 mg/dl. The mean serum uric acid in case group was statistically significant (p=0.038 which was &lt;0.05) lower than that of control group. Serum UA levels gradually diminished as Hoehn &amp; Yahr stage of PD increased. Also, disease duration of PD was found inversely related with serum UA. Male subjects in both case and control group had higher serum UA level than their female counter-part, but they had statistically significant higher UA in control group. In this study no correlation was found between age and BMI with serum UA in both case and control. Any association between serum UA and dietary habit was not found in this study because maximum subjects of this study used to take average protein diet.&#x0D; Conclusion: The aim of the study was to explore the association between serum uric acid with Parkinson Disease. The present study found statistically significant association between low serum uric acid with Parkinson Disease.&#x0D; Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 115-123</jats:p