Non-abelian D=11 Supermembrane

We obtain a U(M) action for supermembranes with central charges in the Light Cone Gauge (LCG). The theory realizes all of the symmetries and constraints of the supermembrane together with the invariance under a U(M) gauge group with M arbitrary. The worldvolume action has (LCG) N=8 supersymmetry and it corresponds to M parallel supermembranes minimally immersed on the target M9xT2 (MIM2). In order to ensure the invariance under the symmetries and to close the corresponding algebra, a star-product determined by the central charge condition is introduced. It is constructed with a nonconstant symplectic two-form where curvature terms are also present. The theory is in the strongly coupled gauge-gravity regime. At low energies, the theory enters in a decoupling limit and it is described by an ordinary N=8 SYM in the IR phase for any number of M2-branes.Comment: Contribution to the Proceedings of the Dubna International SQS'09 Workshop ("Supersymmetries and Quantum Symmetries-2009", July 29 - August 3, 2009. 12pg, Late

Black Holes in Ho\v{r}ava Gravity with Higher Derivative Magnetic Terms

We consider Horava gravity coupled to Maxwell and higher derivative magnetic terms. We construct static spherically symmetric black hole solutions in the low-energy approximation. We calculate the horizon locations and temperatures in the near-extremal limit, for asymptotically flat and (anti-)de Sitter spaces. We also construct a detailed balanced version of the theory, for which we find projectable and non-projectable, non-perturbative solutions.Comment: 17 pages. v2: Up to date with published version; some minor remarks and more reference

Global monopole solutions in Horava gravity

In Horava's theory of gravity coupled to a global monopole source, we seek for static, spherically symmetric spacetime solutions for general values of $\lambda$. We obtain the explicit solutions with deficit solid angles, in the IR modified Horava gravity model, at the IR fixed point $\lambda=1$ and at the conformal point $\lambda=1/3$. For the other values of $1>\lambda>0$ we also find special solutions to the inhomogenous equation of the gravity model with detailed balance, and we discuss an possibility of astrophysical applications of the $\lambda=1/2$ solution that has a deficit angle for a finite range.Comment: 7 pages, added reference

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF.

AIMS: The relationship between outcomes and time after diagnosis for patients with non-valvular atrial fibrillation (NVAF) is poorly defined, especially beyond the first year. METHODS AND RESULTS: GARFIELD-AF is an ongoing, global observational study of adults with newly diagnosed NVAF. Two-year outcomes of 17 162 patients prospectively enrolled in GARFIELD-AF were analysed in light of baseline characteristics, risk profiles for stroke/systemic embolism (SE), and antithrombotic therapy. The mean (standard deviation) age was 69.8 (11.4) years, 43.8% were women, and the mean CHA2DS2-VASc score was 3.3 (1.6); 60.8% of patients were prescribed anticoagulant therapy with/without antiplatelet (AP) therapy, 27.4% AP monotherapy, and 11.8% no antithrombotic therapy. At 2-year follow-up, all-cause mortality, stroke/SE, and major bleeding had occurred at a rate (95% confidence interval) of 3.83 (3.62; 4.05), 1.25 (1.13; 1.38), and 0.70 (0.62; 0.81) per 100 person-years, respectively. Rates for all three major events were highest during the first 4 months. Congestive heart failure, acute coronary syndromes, sudden/unwitnessed death, malignancy, respiratory failure, and infection/sepsis accounted for 65% of all known causes of death and strokes for <10%. Anticoagulant treatment was associated with a 35% lower risk of death. CONCLUSION: The most frequent of the three major outcome measures was death, whose most common causes are not known to be significantly influenced by anticoagulation. This suggests that a more comprehensive approach to the management of NVAF may be needed to improve outcome. This could include, in addition to anticoagulation, interventions targeting modifiable, cause-specific risk factors for death. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Спецкурс "Здоров'яорієнтоване середовище загальноосвітнього навчального закладу" для студентів спеціальності "Здоров'я людини"

The article analyses the present day state of the problem of the pedagogical staff readiness for health-oriented school environment creation. On the results of the pilot research on the readiness of both working and future health basics teachers for health oriented school environment creation a number of problems in the methodological training of the staff has been revealed. Grounding on the results of the experiment results and scientific and methodological literature analysis the "Health Oriented Environment in a General Education Establishment" special course program has been developed. The special course program comprehension will facilitate future health basics teachers to master efficient methods of health oriented school environment creation, which will promote, in the result, their integral professional readiness for provision of the functioning of the environment in a general educational establishment oriented on preservation and improvement of health of all educational process participants.У статті проаналізовано сучасний стан проблеми готовності педагогічних кадрів до створення здоров'яорієнтованого шкільного середовища. За підсумками пілотажного дослідження готовності працюючих та майбутніх учителів основ здоров'я до створення здоров'яорієнтованого шкільного середовища виявлено низку проблем щодо методичної підготовки педагогічних кадрів до цієї роботи. На підставі результатів експерименту та аналізу науково-методичної літератури розроблено програму спецкурсу "Здоров'яорієнтоване середовище загальноосвітнього навчального закладу". Засвоєння програми спецкурсу допоможе майбутнім учителям основ здоров’я опанувати ефективні методи створення здоров’яорієнтованого шкільного середовища, що в підсумку сприятиме формуванню в них цілісної професійної готовності до забезпечення функціонування в загальноосвітньому навчальному закладі шкільного середовища, орієнтованого на збереження та зміцнення здоров'я всіх учасників освітнього процесу

ОСОБЛИВОСТІ ПОВОРОТУ ШАРНІРНО-ЗЧЛЕНОВАНОГО ТРАКТОРА

Предметом досліджень статті є динаміка повороту колісного трактора з шарнірно-зчленованою рамою при особливих умовах функціонування еластичного пневматика. Метою роботи є аналіз моделі руху колісного трактора з шарнірно-зчленованою рамою при врахуванні особливостей формування дотичної сили тяги колеса та динаміки повороту. Завдання дослідження полягають у отриманні залежностей кінематичних характеристик та моменту опору колісного трактора при повороті. Застосовувані методи: методи системного аналізу результатів експериментальних та теоретичних досліджень. Отримані результати: розглянуто задачу повороту трактора з шарнірно-зчленованою рамою на агрофонах з різною несучою здатністю. Проаналізовано формування моменту опору повороту трактора в залежності від кута між повздовжніми вісями секцій. Встановлено, що аналіз процесу повороту, проведений з позицій кінематики окремих секцій, повною мірою не відображає специфіку повороту трактора в різних умовах його експлуатації. Спотворення заданої траєкторії криволінійного руху є наслідком впливу сил взаємодії еластичних пневматиків коліс з ґрунтом і відцентрових сил, що виявляються під час руху на швидкостях, які перевищують 6 км/год. Практична значущість роботи полягає у тому, що, на основі проведеного системного аналізу, введені вимоги на виконання транспортних робіт з метою підвищення тягово-зчіпних властивостей та покращення прохідності транспортно-технологічного агрегату.</jats:p