18 research outputs found
Élastase, collagénase et gliotoxine d’ Aspergillus fumigatus au cours de l’aspergillose invasive murine
Full text linkMarine halogenated compound analysis: from an R package to the isolation of new griseophenone derivatives
Full text linkDevelopment of a liquid-medium assay for screening antimicrobial natural products against marine bacteria
No full textStudy on the usefulness and limitations of a cytotoxicity bio-assay using KB cells to detect lipophilic toxins in shellfish matrices
Full text linkCombining MS/MS fragmentation, correlation and biochemical reaction networks to improve compound annotation in metabolome investigations of marine-derived Penicillium species
Full text linkInvestigation of optimal methods including pH-zone-refining centrifugal partition chromatography for the isolation of communesins from cultures of a marine-derived Penicillium expansum
Full text linkNEW terpenoids from marine-derived Penicillium with potent anticancer activity in osteosarcoma models
Full text linkDeciphering interactions between the marine dinoflagellate Prorocentrum lima and the fungus Aspergillus pseudoglaucus
No full textThe comprehension of microbial interactions is one of the key challenges in marine microbial ecology. This study focused on exploring chemical interactions between the toxic dinoflagellate Prorocentrum lima and a filamentous fungal species, Aspergillus pseudoglaucus, which has been isolated from the microalgal culture. Such interspecies interactions are expected to occur even though they were rarely studied. Here, a co-culture system was designed in a dedicated microscale marine-like condition. This system allowed to explore microalgal-fungal physical and metabolic interactions in presence and absence of the bacterial consortium. Microscopic observation showed an unusual physical contact between the fungal mycelium and dinoflagellate cells. To delineate specialized metabolome alterations during microalgal-fungal co-culture metabolomes were monitored by high-performance liquid chromatography coupled to high-resolution mass spectrometry. In-depth multivariate statistical analysis using dedicated approaches highlighted (1) the metabolic alterations associated with microalgal-fungal co-culture, and (2) the impact of associated bacteria in microalgal metabolome response to fungal interaction. Unfortunately, only a very low number of highlighted features were fully characterised. However, an up-regulation of the dinoflagellate toxins okadaic acid and dinophysistoxin 1 was observed during co-culture in supernatants. Such results highlight the importance to consider microalgal-fungal interactions in the study of parameters regulating toxin production
8′-Hydroxyzearalanone and 2′-Hydroxyzearalanol: Resorcyclic Acid Lactone Derivatives from the Marine-Derived Fungus Penicillium sp.
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