Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to humans and other species. A detailed anatomical study describing the adult morphology is lacking, however. This study describes in detail the musculoskeletal geometry and skeletal muscle architecture of the mouse hindlimb and pelvis, determining the extent to which the muscles are adapted for their function, as inferred from their architecture. Using I2KI enhanced microCT scanning and digital segmentation, it was possible to identify 39 distinct muscles of the hindlimb and pelvis belonging to nine functional groups. The architecture of each of these muscles was determined through microdissections, revealing strong architectural specialisations between the functional groups. The hip extensors and hip adductors showed significantly stronger adaptations towards high contraction velocities and joint control relative to the distal functional groups, which exhibited larger physiological cross sectional areas and longer tendons, adaptations for high force output and elastic energy savings. These results suggest that a proximo-distal gradient in muscle architecture exists in the mouse hindlimb. Such a gradient has been purported to function in aiding locomotor stability and efficiency. The data presented here will be especially valuable to any research with a focus on the architecture or gross anatomy of the mouse hindlimb and pelvis musculature, but also of use to anyone interested in the functional significance of muscle design in relation to quadrupedal locomotion

Butterfly pitch-angle distribution of relativistic electrons in the outer radiation belt: Evidence of nonadiabatic scattering

In this paper we investigate the scattering of relativistic electrons in the nightside outer radiation belt (around the geostationary orbit). We consider the particular case of low geomagnetic activity (|Dst|\u3c20 nT), quiet conditions in the solar wind, and absence of whistler wave emissions. For such conditions we find several events of Van Allen probe observations of butterfly pitch angle distributions of relativistic electrons (energies about 1–3 MeV). Many previous publications have described such pitch angle distributions over a wide energy range as due to the combined effect of outward radial diffusion and magnetopause shadowing. In this paper we discuss another mechanism that produces butterfly distributions over a limited range of electron energies. We suggest that such distributions can be shaped due to relativistic electron scattering in the equatorial plane of magnetic field lines that are locally deformed by currents of hot ions injected into the inner magnetosphere. Analytical estimates, test particle simulations, and observations of the AE index support this scenario. We conclude that even in the rather quiet magnetosphere, small scale (magnetic local time (MLT)-localized) injection of hot ions from the magnetotail can likely influence the relativistic electron scattering. Thus, observations of butterfly pitch angle distributions can serve as an indicator of magnetic field deformations in the nightside inner magnetosphere. We briefly discuss possible theoretical approaches and problems for modeling such nonadiabatic electron scattering

Numerical Arc Segmentation Algorithm for a Radio Conference-NASARC (version 4.0) technical manual

The information contained in the NASARC (Version 4.0) Technical Manual and NASARC (Version 4.0) User's Manual relates to the Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) software development through November 1, 1988. The Technical Manual describes the NASARC concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operation instructions. Significant revisions were incorporated in the Version 4.0 software over prior versions. These revisions have further enhanced the modeling capabilities of the NASARC procedure and provide improved arrangements of predetermined arcs within the geostationary orbits. Array dimensions within the software were structured to fit within the currently available 12 megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 4.0) allows worldwide planning problem scenarios to be accommodated within computer run time and memory constraints with enhanced likelihood and ease of solution

Quantifying the relative contributions of substorm injections and chorus waves to the rapid outward extension of electron radiation belt

Abstract We study the rapid outward extension of the electron radiation belt on a timescale of several hours during three events observed by Radiation Belt Storm Probes and Time History of Events and Macroscale Interactions during Substorms satellites and particularly quantify the contributions of substorm injections and chorus waves to the electron flux enhancement near the outer boundary of radiation belt. A comprehensive analysis including both observations and simulations is performed for the first event on 26 May 2013. The outer boundary of electron radiation belt moved from L = 5.5 to L \u3e 6.07 over about 6 h, with up to 4 orders of magnitude enhancement in the 30 keV to 5 MeV electron fluxes at L = 6. The observations show that the substorm injection can cause 100% and 20% of the total subrelativistic (∼0.1 MeV) and relativistic (2-5 MeV) electron flux enhancements within a few minutes. The data-driven simulation supports that the strong chorus waves can yield 60%-80% of the total energetic (0.2-5.0 MeV) electron flux enhancement within about 6 h. Some simple analyses are further given for the other two events on 2 and 29 June 2013, in which the contributions of substorm injections and chorus waves are shown to be qualitatively comparable to those for the first event. These results clearly illustrate the respective importance of substorm injections and chorus waves for the evolution of radiation belt electrons at different energies on a relatively short timescale. Key Points Rapid outward extension of electron radiation belt observed by RBSP and THEMIS A two-step scenario to explain the rapid flux enchantment Differentiating between contributions of substorm injections and chorus waves

Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC), version 4.0: User's manual

The information in the NASARC (Version 4.0) Technical Manual (NASA-TM-101453) and NASARC (Version 4.0) User's Manual (NASA-TM-101454) relates to the state of Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) software development through November 1, 1988. The Technical Manual describes the NASARC concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operation instructions. Significant revisions were incorporated in the Version 4.0 software over prior versions. These revisions have further enhanced the modeling capabilities of the NASARC procedure and provide improved arrangements of predetermined arcs within the geostationary orbit. Array dimensions within the software were structured to fit within the currently available 12-megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 4.) allows worldwide planning problem scenarios to be accommodated within computer run time and memory constraints with enhanced likelihood and ease of solution

Numerical arc segmentation algorithm for a radio conference-NASARC (version 2.0) technical manual

The information contained in the NASARC (Version 2.0) Technical Manual (NASA TM-100160) and NASARC (Version 2.0) User's Manual (NASA TM-100161) relates to the state of NASARC software development through October 16, 1987. The Technical Manual describes the Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operating instructions. Significant revisions have been incorporated in the Version 2.0 software. These revisions have enhanced the modeling capabilities of the NASARC procedure while greatly reducing the computer run time and memory requirements. Array dimensions within the software have been structured to fit within the currently available 6-megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 2.0) allows worldwide scenarios to be accommodated within these memory constraints while at the same time effecting an overall reduction in computer run time

Numerical arc segmentation algorithm for a radio conference: A software tool for communication satellite systems planning

The Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) provides a method of generating predetermined arc segments for use in the development of an allotment planning procedure to be carried out at the 1988 World Administrative Radio Conference (WARC) on the Use of the Geostationary Satellite Orbit and the Planning of Space Services Utilizing It. Through careful selection of the predetermined arc (PDA) for each administration, flexibility can be increased in terms of choice of system technical characteristics and specific orbit location while reducing the need for coordination among administrations. The NASARC software determines pairwise compatibility between all possible service areas at discrete arc locations. NASARC then exhaustively enumerates groups of administrations whose satellites can be closely located in orbit, and finds the arc segment over which each such compatible group exists. From the set of all possible compatible groupings, groups and their associated arc segments are selected using a heuristic procedure such that a PDA is identified for each administration. Various aspects of the NASARC concept and how the software accomplishes specific features of allotment planning are discussed