Geoneutrinos in Borexino

This paper describes the Borexino detector and the high-radiopurity studies and tests that are integral part of the Borexino technology and development. The application of Borexino to the detection and studies of geoneutrinos is discussed.Comment: Conference: Neutrino Geophysics Honolulu, Hawaii December 14-16, 200

Precision Measurement Of The Neutron's Beta Asymmetry Using Ultra-Cold Neutrons

A measurement of A_β, the correlation between the electron momentum and neutron (n) spin (the beta asymmetry) in n beta-decay, together with the n lifetime, provides a method for extracting fundamental parameters for the charged-current weak interaction of the nucleon. In particular when combined with decay measurements, one can extract the V_(ud) element of the CKM matrix, a critical element in CKM unitarity tests. By using a new SD_2 super-thermal source at LANSCE, large fluxes of UCN (ultra-cold neutrons) are expected for the UCNA project. These UCN will be 100% polarized using a 7 T magnetic field, and directed into the β spectrometer. This approach, together with an expected large reduction in backgrounds, will result in an order of magnitude reduction in the critical systematic corrections associated with current n β-asymmetry measurements. This paper will give an overview of the UCNA Aβ measurement as well as an update on the status of the experiment

The Effects of Dissolved Methane upon Liquid Argon Scintillation Light

In this paper we report on measurements of the effects of dissolved methane upon argon scintillation light. We monitor the light yield from an alpha source held 20 cm from a cryogenic photomultiplier tube (PMT) assembly as methane is injected into a high-purity liquid argon volume. We observe significant suppression of the scintillation light yield by dissolved methane at the 10 part per billion (ppb) level. By examining the late scintillation light time constant, we determine that this loss is caused by an absorption process and also see some evidence of methane-induced scintillation quenching at higher concentrations (50-100 ppb). Using a second PMT assembly we look for visible re-emission features from the dissolved methane which have been reported in gas-phase argon methane mixtures, and we find no evidence of visible re-emission from liquid-phase argon methane mixtures at concentrations between 10 ppb and 0.1%.Comment: 18 pages, 11 figures Updated to match published versio

The composition of Event-B models

The transition from classical B [2] to the Event-B language and method [3] has seen the removal of some forms of model structuring and composition, with the intention of reinventing them in future. This work contributes to thatreinvention. Inspired by a proposed method for state-based decomposition and refinement [5] of an Event-B model, we propose a familiar parallel event composition (over disjoint state variable lists), and the less familiar event fusion (over intersecting state variable lists). A brief motivation is provided for these and other forms of composition of models, in terms of feature-based modelling. We show that model consistency is preserved under such compositions. More significantly we show that model composition preserves refinement

Is soft physics entropy driven?

The soft physics, pT < 2 GeV/c, observables at both RHIC and the SPS have now been mapped out in quite specific detail. From these results there is mounting evidence that this regime is primarily driven by the multiplicity per unit rapidity, dNch/deta. This suggests that the entropy of the system alone is the underlying driving force for many of the global observables measured in heavy-ion collisions. That this is the case and there is an apparent independence on collision energy is surprising. I present the evidence for this multiplicity scaling and use it to make some extremely naive predictions for the soft sector results at the LHC.Comment: Proceedings of Hot Quarks 2006. 8 figures, 6 page

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine.

Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g., brain and lymphocyte) are major limitations to current regimens. Previous studies have indicated that the antimalarial drug chloroquine (CQ) has antiviral efficacy and a synergism with HIV protease inhibitors. We have screened a panel of antimalarial compounds for activity against HIV-1 in vitro. A limited efficacy was observed for CQ, mefloquine (MQ), and mepacrine (MC). However, marked synergy was observed between MQ and saquinavir (SQV), but not CQ in U937 cells. Furthermore, enhancement of the antiviral activity of SQV and four other protease inhibitors (PIs) by MQ was observed in MT4 cells, indicating a class specific rather than a drug-specific phenomenon. We demonstrate that these observations are a result of inhibition of multiple drug efflux proteins by MQ and that MQ also displaces SQV from orosomucoid in vitro. Finally, coadministration of MQ and SQV in CD-1 mice dramatically altered the tissue distribution of SQV, resulting in a >3-fold and >2-fold increase in the tissue/blood ratio for brain and testis, respectively. This pharmacological enhancement of in vitro antiviral activity of PIs by MQ now warrants further examination in vivo

NeXSPheRIO results on elliptic flow at RHIC and connection with thermalization

Elliptic flow at RHIC is computed event-by-event with NeXSPheRIO. Reasonable agreement with experimental results on $v_2(\eta)$ is obtained. Various effects are studied as well: reconstruction of impact parameter direction, freeze out temperature, equation of state (with or without crossover), emission mecanism.Comment: Contribution to the Proceedings of the Quark-Gluon Plasma Thermalization workshop. Content slightly increase